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Lactobacillus kefiranofaciens

Also known as: Lactobacillus kefiranofaciens, Kefir lactobacillus, L. kefiranofaciens

Overview

Lactobacillus kefiranofaciens is a species of lactic acid bacteria isolated from kefir grains, characterized as a slime-forming, homofermentative, rod-shaped bacterium. It is primarily used for its potential health benefits, including immune modulation, anti-inflammatory effects, and improvement of intestinal health. This probiotic is known for its ability to produce exopolysaccharides (EPS) and its role in regulating gut microbiota and immune responses. Research on L. kefiranofaciens is relatively mature, with several in vitro and in vivo studies, as well as some animal models, investigating its effects on various health conditions. However, large-scale human clinical trials and systematic reviews are lacking. It is generally considered safe, with no significant adverse health effects reported in the studies reviewed. The bacterium interacts with the gut microbiota, influencing the composition and function of the intestinal microbiome. It also affects the immune system by regulating cytokine expression and cell adhesion genes.

Benefits

Lactobacillus kefiranofaciens exhibits several evidence-based benefits. It modulates the immune system by upregulating regulatory T cells and reducing the expression of proinflammatory cytokines, which has been shown to reduce eosinophil infiltration and mucus production in asthma-induced mice. In animal models of dextran sodium sulphate (DSS)-induced colitis, it reduces colonic damage, preserves goblet cells, and promotes autophagy, thereby protecting the intestinal barrier. While not specific to L. kefiranofaciens M1, some evidence suggests that related strains may contribute to anti-obesity effects by regulating energy homeostasis and lipid metabolism. Additionally, certain strains may improve depression by regulating the gut microbiota. These benefits have been observed over time frames ranging from a few days to several weeks, depending on the specific study and health outcome.

How it works

Lactobacillus kefiranofaciens modulates the immune system, upregulating regulatory T cells and inhibiting the secretion of proinflammatory cytokines. It improves epithelial barrier function and promotes autophagy. The bacterium interacts with the gut microbiota, influencing the composition and function of the intestinal microbiome. It also affects the immune system by regulating cytokine expression and cell adhesion genes. L. kefiranofaciens targets various immune-related genes and pathways, including those involved in inflammation and cell adhesion. It also influences the expression of genes associated with the classic complement pathway and lectin-induced pathway. The bioavailability of L. kefiranofaciens is typically ensured through its administration in a viable form, often as part of a probiotic supplement or kefir culture.

Side effects

Lactobacillus kefiranofaciens is generally considered safe, with no significant adverse health effects reported in the studies reviewed. There are no reported common, uncommon, or rare side effects associated with its use. No significant drug interactions have been reported, and there are no known contraindications for its use. However, the safety and efficacy in special populations, such as pregnant women, children, and immunocompromised individuals, have not been extensively studied. While generally safe, it's always prudent to consult with a healthcare provider before starting any new supplement, especially for individuals with underlying health conditions or those taking medications. Although no specific side effects have been documented, individual responses to probiotics can vary.

Dosage

The minimum effective dose of Lactobacillus kefiranofaciens varies by study but typically ranges from 10^8 to 10^9 CFU (Colony-Forming Units) per administration. Optimal dosages are generally in the range of 10^8 to 10^9 CFU per day, administered intragastrically or as part of a probiotic supplement. There is no established maximum safe dose, but doses up to 10^9 CFU have been used without adverse effects. The timing of administration can vary but is often daily. L. kefiranofaciens can be administered as part of a kefir culture, probiotic supplement, or in a purified form. The bioavailability is generally ensured through viable cell administration. No specific cofactors are required for the efficacy of L. kefiranofaciens.

FAQs

Is Lactobacillus kefiranofaciens safe?

Lactobacillus kefiranofaciens is considered safe with no reported adverse health effects in the studies reviewed. However, consult a healthcare provider before starting any new supplement.

How should I take Lactobacillus kefiranofaciens?

It can be administered daily, typically in the form of a probiotic supplement or kefir culture, with dosages ranging from 10^8 to 10^9 CFU per day.

What benefits can I expect from taking Lactobacillus kefiranofaciens?

Users can expect improvements in immune function, intestinal health, and potentially in conditions such as asthma and colitis, based on available research.

Are there any side effects or interactions with Lactobacillus kefiranofaciens?

There is no evidence to suggest that Lactobacillus kefiranofaciens has any significant side effects or interactions, but individual responses can vary. Consult a healthcare provider.

Research Sources

https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2020.01454/full – This animal study investigated the mechanistic differences of obesity-inducing and anti-obesity effects of L. kefiranofaciens M1 and L. mali APS1. The study found that these strains influenced fat accumulation and lipid metabolism in HFD-induced obese mice by regulating adipogenesis and inflammation, highlighting their potential role in managing obesity.
https://www.mdpi.com/2072-6643/11/6/1252 – This review article analyzed the health benefits conferred by Lactobacillus species from kefir, including L. kefiranofaciens M1. The review demonstrated immune-modulating activities, reduced allergic and inflammatory responses, and improved intestinal health associated with L. kefiranofaciens, providing a broad overview of its potential health benefits.
https://www.microbiologyresearch.org/content/journal/ijsem/10.1099/00207713-38-1-12 – This paper provides the taxonomic description of Lactobacillus kefiranofaciens. It details the characteristics that differentiate it from other Lactobacillus species, including its slime-forming properties and its ability to produce exopolysaccharides. This information is fundamental for identifying and classifying this specific probiotic strain.
https://pubmed.ncbi.nlm.nih.gov/30698577/ – This study investigates the impact of Lactobacillus kefiranofaciens ZW3 on depression by regulating the gut microbiota. The findings suggest that this strain has the potential to improve mental health by modulating the composition and function of the intestinal microbiome, offering a novel approach to treating depression.
https://academic.oup.com/ecco-jcc/article/14/Supplement_1/S162/5705023 – This animal study showed that Lactobacillus kefiranofaciens promotes autophagy and protects the intestinal barrier. The study found that L. kefiranofaciens reduced the severity of DSS-induced colitis, preserved goblet cells, and promoted autophagy, suggesting its potential in managing inflammatory bowel diseases.

Score: 87/100

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