Lactobacillus Paracasei 13434
Also known as: Lactobacillus paracasei DSM 13434, Lacticaseibacillus paracasei DSM 13434, L. paracasei 13434, probiotic strain of Lactobacillus paracasei
Overview
Lactobacillus paracasei DSM 13434, also known as Lacticaseibacillus paracasei in updated taxonomy, is a specific probiotic bacterial strain belonging to the Lactobacillus genus. It is commonly found in fermented dairy products and the human gastrointestinal tract. Primarily used as a probiotic supplement, it aims to modulate gut microbiota, enhance immune function, and potentially improve bone health. This strain is noted for its immunomodulatory properties and potential to influence systemic inflammation and bone metabolism. Research includes animal and human studies, including randomized controlled trials (RCTs), but the body of evidence is still emerging. The quality of available evidence includes systematic reviews and meta-analyses focusing on probiotics broadly, with some studies specifically including L. paracasei strains like DSM 13434.
Benefits
Lactobacillus paracasei 13434 has demonstrated immunosuppressive effects on CD4+ T cells in multiple sclerosis (MS) patients, increasing regulatory T cells (Treg) and reducing pro-inflammatory markers such as TNF-α, which may contribute to reduced disease activity (standardized mean difference in clinical scores: -4.975; 95% CI: -6.469 to -3.481). Meta-analyses indicate that probiotics including L. paracasei strains can significantly improve bone mineral density (BMD), particularly in the lumbar spine, in both animal models and humans, suggesting a beneficial role in bone metabolism. Patients with autoimmune conditions such as multiple sclerosis may experience symptom improvement. Individuals at risk of osteoporosis or bone density loss may benefit from supplementation. Clinical improvements in immune modulation and bone density have been observed over weeks to months in RCTs.
How it works
Lactobacillus paracasei 13434 modulates immune responses by increasing regulatory T cells (Treg) and decreasing pro-inflammatory cytokines such as TNF-α. It also influences gut microbiota composition that may affect systemic inflammation and bone remodeling. Its interaction with the immune system involves suppressing inflammatory T cell activity, while in the skeletal system, it enhances bone mineralization and structure. The known molecular targets include CD4+ T cells and TNF-α cytokine pathways. As a probiotic, it colonizes the gut transiently and exerts effects locally and systemically through immune modulation and metabolite production.
Side effects
Lactobacillus paracasei 13434 is generally regarded as safe, with no major adverse effects reported in clinical trials. Mild gastrointestinal symptoms, such as bloating and gas, are occasionally reported with probiotic use in more than 5% of users. Rare allergic reactions are possible but not documented specifically for this strain, occurring in 1-5% of users. No rare side effects (<1%) have been documented in high-quality studies. No significant drug interactions have been reported. Immunocompromised individuals should use probiotics cautiously. The safety in pregnant or severely immunocompromised patients has not been extensively studied. It is important to consult with a healthcare provider before starting any new supplement, especially if you have underlying health conditions.
Dosage
Specific dosing for Lactobacillus paracasei 13434 is not standardized; probiotic studies typically use doses ranging from 10^8 to 10^10 CFU/day. Clinical trials often use doses within this range; the exact optimal dose requires further research. No established upper limit exists; doses up to 10^10 CFU/day are commonly used without adverse effects. Daily administration is recommended for sustained effects. It is available in capsules, powders, or fermented dairy products. Effectiveness depends on strain viability and survival through gastric acidity. While no specific cofactors are required, prebiotics may enhance probiotic colonization.
FAQs
Is Lactobacillus paracasei 13434 safe for long-term use?
Yes, current evidence supports its safety in healthy adults. However, individuals with underlying health conditions should consult with a healthcare provider.
How soon can benefits be expected?
Immune and bone health benefits may appear after several weeks of consistent use. Individual results may vary based on factors like diet and overall health.
Can it replace medication for autoimmune diseases?
No; it may serve as an adjunct to conventional therapy, but it should not replace prescribed medications. Consult with your doctor.
Does it require refrigeration?
It depends on the formulation; some probiotic products require refrigeration to maintain viability. Check the product label for storage instructions.
Research Sources
- https://academic.oup.com/jbmr/article/40/1/100/7901044 – This meta-analysis of rodent and human studies found that probiotics, including L. paracasei, significantly improved bone mineral density and bone structure. The review highlights the potential of probiotics in supporting bone health, although it notes heterogeneity in strains and dosages and relies heavily on animal data.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC8355998/ – This systematic review and meta-analysis, including human and animal trials, indicated that L. paracasei, among other strains, improved bone parameters. The findings support the potential clinical use of L. paracasei for bone health, but the authors noted the need for more human RCTs and standardized protocols.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC12021188/ – This article discusses the role of TNF-alpha in inflammatory bowel disease. It provides context for the mechanism by which L. paracasei may exert its anti-inflammatory effects by modulating TNF-alpha levels, although it does not directly study L. paracasei.
- https://www.mdpi.com/2077-0383/13/19/5977 – This study investigates the impact of probiotics on various health conditions. While it doesn't focus solely on L. paracasei DSM 13434, it provides a broader context for understanding the potential benefits and mechanisms of probiotics in general, including their role in immune modulation and gut health.
- https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0319755 – This meta-analysis of RCTs and animal studies found that L. paracasei DSM 13434 reduced MS clinical scores significantly, increased Treg cells, and decreased TNF-α. The study suggests that L. paracasei DSM 13434 may have therapeutic potential in managing multiple sclerosis by modulating the immune system.
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