Get Your Personalized Supplement StackSupplement Stack Quiz

Leuconostoc Dextranicum

Also known as: Leuconostoc, Leuconostoc mesenteroides, Leuconostoc species, Ln. mesenteroides

Overview

*Leuconostoc mesenteroides* is a lactic acid bacterium commonly found in fermented foods like dairy, meats, and vegetables. It's known for its role in fermentation and the production of dextran, a polysaccharide with applications in food, pharmaceuticals, and medicine. *Leuconostoc* species are gram-positive, facultatively anaerobic, and tolerant to environmental stresses. They produce bacteriocins and exopolysaccharides. Research is ongoing, with high-quality evidence from genomic studies, in vitro experiments, and some in vivo trials. More human clinical trials are needed to fully understand the health benefits of *Leuconostoc* supplements. Dextran's molecular weight and structure can be modified through fermentation, influencing its properties and applications. *Leuconostoc* is used as a starter culture in food production and as a source of dextran for various industrial purposes.

Benefits

*Leuconostoc mesenteroides* is a primary producer of dextran, used industrially and medically. Fermentation conditions can alter dextran's molecular weight. Some *Leuconostoc* species may have immunomodulatory effects and support gut health. *Leuconostoc carnosum* inhibits *Listeria monocytogenes* and may benefit the immune system in animal models. *Leuconostoc* species contribute to food preservation by producing antimicrobial compounds. Some strains produce exopolysaccharides and biogenic amines, potentially offering health benefits, but more research is needed. Animal studies suggest *Leuconostoc* supplements benefit gut health, but human trials are needed to confirm these effects and determine clinical significance. Benefits in animal studies are observed within days to weeks of supplementation.

How it works

*Leuconostoc* species function through fermentation, producing lactic acid, bacteriocins, and exopolysaccharides like dextran. These compounds inhibit pathogenic bacteria and modulate the immune system. They colonize the gut, producing antimicrobial compounds and influencing immune responses. Molecular targets include pathogens like *Listeria monocytogenes*, inhibited by *Leuconostoc*'s bacteriocins. The absorption and bioavailability of *Leuconostoc* supplements, especially dextran, depend on the form and dosage. Dextran is generally well-tolerated and can be absorbed, but specific bioavailability data for *Leuconostoc* supplements are limited.

Side effects

*Leuconostoc* species are generally recognized as safe (GRAS) for food use. However, the safety of *Leuconostoc* supplements, especially in high doses or long-term, isn't well-documented. Limited data exists on specific side effects. Probiotics, in general, may cause gastrointestinal symptoms like bloating or gas. Uncommon side effects may include allergic reactions or interactions with medications. Rare side effects, such as severe allergic reactions or infections in immunocompromised individuals, are theoretical but not well-documented. Probiotics can interact with immunosuppressants or affect antibiotic efficacy. Contraindications may include severe immune deficiencies or critical illness. Special considerations are needed for pregnant/breastfeeding women and children due to limited safety data.

Dosage

The minimum effective dose for *Leuconostoc* supplements is not well-established. Dosages in animal studies vary widely; human trials are needed. Optimal dosage ranges are undefined and may depend on the strain and intended use. The maximum safe dose is not established, but *Leuconostoc* species are generally considered safe in food. Timing considerations are not well-defined. Forms include capsules, powders, or fermented foods, which may affect absorption. Absorption factors are not extensively studied but may include the presence of other nutrients or the supplement form. Required cofactors are not well-documented but may include other probiotic strains or prebiotic fibers.

FAQs

Are *Leuconostoc* supplements safe?

*Leuconostoc* species are generally safe, but long-term safety data in humans is limited. Consult a healthcare provider before starting supplementation.

When and how should I take *Leuconostoc* supplements?

The optimal timing and administration protocol is not well-defined and may vary based on the specific application. Follow product-specific instructions.

What results can I expect from taking *Leuconostoc* supplements?

Potential benefits include gut health and immune system modulation, but these are more clearly established in animal studies. Individual results may vary.

Are all *Leuconostoc* supplements the same?

No, different strains and forms may have different benefits and safety profiles. Choose supplements based on specific needs and research.

Research Sources

https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2017.00132/full – This genomic analysis of dairy-associated *Leuconostoc* species revealed significant differences in metabolic potential and population composition among commercial starter cultures. The study found that *Ln. mesenteroides* subspecies *cremoris* and *Leuconostoc pseudomesenteroides* were dominant in different cultures, highlighting the diversity within *Leuconostoc* species used in dairy fermentation.
https://pubmed.ncbi.nlm.nih.gov/29553034/ – This study investigated the phenotypic traits and immunomodulatory properties of *Leuconostoc carnosum* strains. The results showed that these strains exhibited immunomodulatory effects, inhibited *Listeria monocytogenes*, and successfully colonized the intestines of mice, suggesting potential probiotic applications and tolerance to osmotic and oxidative stress.
https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2021.730827/full – This research further supports the immunomodulatory effects and probiotic potential of *Leuconostoc* strains, emphasizing their role in inhibiting pathogenic bacteria and modulating the immune system. The study highlights the importance of strain-specific characteristics in determining the effectiveness of *Leuconostoc* as a probiotic.
https://pubmed.ncbi.nlm.nih.gov/34134667/ – This study provides additional evidence for the health-related properties of *Leuconostoc* strains, focusing on their ability to produce exopolysaccharides and biogenic amines. The findings suggest potential benefits for gut health and immune function, although further research is needed to fully elucidate these effects.
https://food.ec.europa.eu/document/download/fcede9cc-7038-4b2c-ad91-c6f6d5808706_en?filename=sci-com_scf_out75_en.pdf – This safety assessment concludes that dextran from *Leuconostoc mesenteroides* is safe for use in food and other applications. The assessment characterizes the molecular weight and polydispersity of dextran, providing a basis for its safe use in various industries.