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Meso Zeaxanthin

Also known as: MZ, Meso-zeaxanthin

Overview

Meso-zeaxanthin (MZ) is a carotenoid primarily located in the human macula, where it is joined by lutein and zeaxanthin. It is derived from dietary sources, particularly green leafy vegetables, and is also available as a supplement. This carotenoid plays an essential role in protecting eye health, evidenced by its antioxidant and anti-inflammatory properties. Research indicates that MZ supplementation can improve macular pigment optical density (MPOD), potentially reducing the risk of age-related macular degeneration (AMD). MZ is gaining attention due to its cumulative effects on visual function and ocular health, with ongoing studies exploring its efficacy and impact on retinal health.

Benefits

Meso-zeaxanthin has been associated with significant benefits for eye health. Key evidence supports MZ's ability to increase MPOD, which correlates with improved visual function and a reduced risk of AMD. A meta-analysis revealed substantial increases in MPOD across both AMD patients and healthy individuals with MZ supplementation. Secondary benefits include its antioxidant and anti-inflammatory effects, aiding in protecting the retina from oxidative stress. The most notable effects can be observed in individuals with AMD and those aiming to maintain their ocular health, with higher doses (>20 mg/day of total carotenoids) correlating with more pronounced improvements. Benefits manifest after several months of regular supplementation.

How it works

Meso-zeaxanthin functions primarily as an antioxidant in the retina, filtering harmful blue light and mitigating oxidative damage. It enhances the macular pigment density, which provides physical protection to retinal cells. MZ scavenges reactive oxygen species (ROS) and potentially influences cytochrome P450 enzymes involved in oxidative stress regulation. The absorption and bioavailability of MZ may vary among individuals, with noted differences in gender affecting the rates of absorption. This outlined mechanism underpins the carotenoid's utility in visual health.

Side effects

Meso-zeaxanthin is generally considered safe when used appropriately, with a low incidence of adverse effects reported in supplement studies. The most commonly noted side effect is gastrointestinal discomfort, which is not widespread. Rarely reported adverse effects suggest that MZ is well-tolerated. There is limited data on drug interactions; caution is advised when combined with medications that influence carotenoid metabolism. While no specific contraindications are established, it is recommended that pregnant or breastfeeding women consult their healthcare providers prior to supplement use, ensuring safety and appropriateness.

Dosage

The optimal dosage of meso-zeaxanthin is often administered in combination with lutein and zeaxanthin, typically exceeding 20 mg/day of total carotenoids for enhanced efficacy. While the minimum effective dose is not well-documented, regular consumption of associated supplements is recommended. To maximize absorption, MZ should ideally be taken with meals, especially those containing fats due to its fat-soluble nature. Capsules or softgels are common forms, and consistent daily intake is advised. Currently, there is no established upper limit, but doses are generally considered safe within recommended dietary framework.

FAQs

How should I take meso-zeaxanthin?

It's often recommended to take MZ with meals for optimal absorption, typically in combination with other carotenoids.

Is meso-zeaxanthin safe to use?

Meso-zeaxanthin is generally regarded as safe; however, some individuals may experience gastrointestinal upset.

What results can I expect from meso-zeaxanthin supplementation?

Supplementation may lead to improved macular pigment density and potential visual health benefits, evident over several months.

Can meso-zeaxanthin cure age-related macular degeneration?

Meso-zeaxanthin is not a cure for AMD but may support ocular health and reduce risk factors associated with the condition.

Are there any drug interactions with meso-zeaxanthin?

Due to limited data, caution is advised when using MZ with medications that interact with carotenoid metabolism.

Research Sources

https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.778165/full – This meta-analysis evaluated the effects of carotenoid supplementation on MPOD, revealing significant increases in both AMD patients and healthy subjects associated with the intake of lutein, zeaxanthin, and meso-zeaxanthin.
https://medcraveonline.com/AOVS/meso-zeaxanthin-mz-current-perspectives-and-new-insights.html – This systematic review discusses the antioxidant and anti-inflammatory properties of meso-zeaxanthin, noting its potential role in supporting visual health despite a limited number of randomized controlled trials focused specifically on MZ.
https://pubmed.ncbi.nlm.nih.gov/34157098/ – An in vitro study demonstrated that meso-zeaxanthin, in combination with 1,25(OH)2D3, can prevent cell damage in models of AMD, offering insights into its protective mechanisms.