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Morus Alba Leaf Extract

Also known as: Morus alba Linn., Mulberry, White Mulberry, Morus alba

Overview

Morus alba, commonly known as white mulberry, is a herbal supplement derived from the leaves of the mulberry tree. It is primarily recognized for its potential to manage blood glucose levels, aid in weight management, and improve lipid profiles. The active compounds in Morus alba, such as 1-deoxynojirimycin (1-DNJ), are believed to inhibit intestinal alpha-glucosidases, reducing glucose absorption. It is available in various forms, including leaf extracts and capsules. While research is ongoing, current evidence suggests that Morus alba may offer benefits for individuals with hyperglycemia or dyslipidemia. However, the quality of evidence varies, and more robust studies are needed to confirm its efficacy across different health outcomes. As a supplement, it is often used as a complementary therapy alongside conventional treatments.

Benefits

Morus alba has demonstrated potential benefits in managing blood glucose levels, particularly postprandial glucose. Studies have shown significant reductions in glucose levels at 30, 60, and 90 minutes after consumption. Some research suggests modest improvements in lipid profiles, including reductions in triglycerides and LDL cholesterol, and increases in HDL cholesterol. Limited evidence indicates potential benefits for weight management and anti-obesity effects. These benefits are most pronounced in individuals with hyperglycemia or dyslipidemia. The effect sizes for glucose reduction are moderate, with mean differences ranging from -0.55 to -1.04 mmol/L. Lipid profile improvements have also been noted but require further validation through additional research.

How it works

Morus alba primarily works by inhibiting intestinal alpha-glucosidases, enzymes responsible for breaking down complex carbohydrates into glucose. The compound 1-deoxynojirimycin (1-DNJ) is a key component that contributes to this mechanism. By inhibiting these enzymes, Morus alba reduces the absorption of glucose into the bloodstream, leading to lower postprandial glucose levels. This interaction primarily affects the digestive system and glucose metabolism. While the bioavailability of active compounds is not fully understood, they appear to be effective when consumed with meals, suggesting that food intake may enhance their absorption or activity.

Side effects

Morus alba is generally considered safe, with no serious adverse effects consistently reported in clinical trials. However, as with many herbal supplements, gastrointestinal upset is a possible side effect. Potential drug interactions exist, particularly with diabetes medications, due to its glucose-lowering effects. Individuals with diabetes or those taking medications that affect blood sugar levels should exercise caution and monitor their blood glucose levels closely. It is also advised that pregnant or breastfeeding women consult healthcare providers before using Morus alba. While uncommon and rare side effects are not well-documented, it is essential to be aware of potential individual reactions and to discontinue use if any adverse effects occur.

Dosage

The minimum effective dose of Morus alba is not well-established, but extracts containing 1-DNJ have shown efficacy in studies. Typical dosage ranges vary from 280 mg to several grams per day, often taken before meals to maximize its effect on glucose absorption. The maximum safe dose is not clearly defined, and high doses are generally not recommended without medical supervision. Leaf extracts are the most common form used. Bioavailability may be enhanced when consumed with meals. It is crucial to adhere to recommended dosages and consult with a healthcare provider, especially for individuals with pre-existing health conditions or those taking medications that affect blood sugar levels.

FAQs

Who should be cautious when using Morus alba?

Individuals with diabetes or those taking medications that affect blood sugar levels should use Morus alba with caution and under medical supervision due to potential interactions.

When is the best time to take Morus alba?

Morus alba is best taken before meals to maximize its glucose-lowering effects by inhibiting the absorption of glucose from the consumed food.

Is Morus alba a replacement for diabetes medication?

No, Morus alba is not a replacement for standard diabetes treatments but may be used as a complementary therapy under the guidance of a healthcare professional.

What are the expected results of taking Morus alba?

Users may experience noticeable reductions in postprandial glucose levels and potential improvements in lipid profiles with consistent use, as supported by research.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/26972284/ – This meta-analysis of 13 RCTs found that Morus alba significantly reduces postprandial glucose levels. However, it did not show consistent effects on other glycemic or lipid markers. The study highlights the need for more large-scale trials to validate these findings.
https://onlinelibrary.wiley.com/doi/10.1111/jcpt.13822 – This systematic review and meta-analysis suggests that mulberry consumption may favorably affect cardiometabolic risk factors. While the review provides a broad overview, specific details on Morus alba leaf extract are limited, indicating a need for more focused research.
https://www.frontiersin.org/journals/clinical-diabetes-and-healthcare/articles/10.3389/fcdhc.2024.1395688/full – This review indicates that Morus alba may have beneficial effects on weight management and metabolic parameters. However, the evidence is based on preclinical and small-scale clinical data, suggesting that more robust clinical trials are necessary to confirm these potential benefits.
https://www.mooiverouderen.com/wp-content/uploads/2024/06/Mulberryleafectract_2023_review.pdf – This review provides an overview of the current research on mulberry leaf extract, highlighting its potential benefits for various health conditions. It emphasizes the need for further studies to fully understand its efficacy and safety.
https://journals.sagepub.com/doi/abs/10.1177/18785093251320209 – This study investigates the effects of Morus alba on specific health outcomes. The abstract suggests potential benefits, but access to the full text is required for a comprehensive summary of the methodology and key findings.