Natrum phosphoricum
Also known as: Natrum phosphoricum, sodium phosphate dibasic, Nat. Phos.
Overview
Natrum phosphoricum, chemically known as sodium phosphate dibasic (Na2HPO4), is a mineral salt naturally present in the human body and various biological fluids. In homeopathy, it is classified as a "cell salt" or biochemic salt and is utilized in highly diluted forms, commonly at 6X potency. It is primarily employed in homeopathic practice for addressing symptoms associated with excess acidity, such as acid reflux, indigestion, heartburn, and gas. Traditional homeopathic claims also suggest its role in supporting overall digestion and alleviating joint pain linked to elevated uric acid levels. As a homeopathic remedy, its intended function is to help balance the body's acid-base status and support digestive processes. The research supporting its efficacy is largely confined to homeopathic studies, with limited rigorous clinical trials available in conventional medicine.
Benefits
Natrum phosphoricum is primarily used in homeopathy for acid-related digestive issues. Some homeopathic studies suggest it may help reduce symptoms of gastroesophageal reflux disease (GORD) and indigestion. For instance, one randomized controlled trial involving 30 patients showed a 42.19% improvement in the group receiving Natrum phosphoricum alongside other homeopathic medicine, compared to a 65.77% improvement in the control group receiving only homeopathic medicine. This particular study did not demonstrate a statistically significant superiority of Natrum phosphoricum, indicating inconsistent or unclear benefits. Traditionally, it is believed to neutralize excess stomach acid and alleviate associated burning sensations. Anecdotal reports also suggest potential benefits in the digestion of fats and proteins, and in reducing uric acid-related joint pain, but these claims lack robust clinical validation. Its use is primarily in adults experiencing acid-related digestive complaints, with limited documentation for pediatric use. Quantitative data on effect sizes and clinical significance are scarce, and the time course of benefits is not well-documented in clinical trials.
How it works
In homeopathy, Natrum phosphoricum's mechanism of action is theorized to involve restoring mineral balance and acid-base homeostasis within the body, although this concept lacks validation in conventional biochemistry. It is believed to primarily act on the digestive system by neutralizing excess acid and promoting more efficient digestion. However, no specific molecular targets have been established in conventional pharmacology. Due to the extreme dilutions used in homeopathic preparations (e.g., 6X), it is unlikely to provide pharmacologically active doses. Consequently, its absorption and bioavailability are not well characterized in a conventional sense, as its effects are not attributed to direct chemical interaction but rather to energetic or informational properties within the homeopathic framework.
Side effects
Natrum phosphoricum is generally considered safe, particularly due to the high dilutions used in homeopathic preparations, which result in minimal to no active chemical substance. As such, adverse effects are rare and not well-documented in conventional medical literature. There are no common side effects reported (i.e., occurring in more than 5% of users). Uncommon side effects (1-5%) may include a transient worsening of symptoms, known as "homeopathic aggravation," which is a recognized phenomenon in homeopathic practice. Rare side effects (less than 1%) have not been reported. There are no known drug interactions with Natrum phosphoricum. Formal contraindications have not been established. However, caution is advised for pregnant and breastfeeding individuals due to a lack of specific safety data in these populations; consultation with a healthcare provider is recommended before use. Given its highly diluted nature, the risk of toxicity or overdose is considered very low.
Dosage
The minimum effective dose for Natrum phosphoricum has not been established due to the limited robust clinical data available. The common homeopathic dosing recommendation is Natrum phosphoricum 6X potency, typically one tablet dissolved under the tongue three times daily. For acute symptoms, product labeling may suggest increasing the frequency to every 15 minutes, for up to eight doses. There is no reported toxicity at homeopathic doses, indicating a very high maximum safe dose from a conventional pharmacological perspective due to the extreme dilution. The preferred form is sublingual tablets, as this administration route is intended to facilitate absorption, though the concept of absorption for highly diluted homeopathic remedies differs from conventional pharmacology. No specific cofactors are identified as necessary for its action.
FAQs
Is Natrum phosphoricum effective for acid reflux?
Evidence for its effectiveness in acid reflux is limited and inconsistent. Some small homeopathic studies suggest potential benefits, but these lack rigorous confirmation from large, well-designed clinical trials.
Is it safe to use?
Yes, Natrum phosphoricum is generally considered safe at homeopathic dilutions. Due to the extreme dilution, the risk of side effects is minimal, and no significant adverse reactions have been reported.
How quickly does it work?
The time course of benefits is not well-documented in clinical trials. Anecdotal reports vary, and there is no robust data to indicate how quickly effects might be observed.
Can it be combined with other treatments?
Natrum phosphoricum is typically used alongside other homeopathic remedies. There are no known harmful interactions with conventional medications, but always consult a healthcare provider.
Is there a risk of overdose?
The risk of overdose is very low due to the high dilution of Natrum phosphoricum in homeopathic preparations. It contains virtually no active chemical substance.
Research Sources
- https://mhmc.org.in/wp-content/uploads/2022/09/Evaluation-of-the-effect-of-homoeopathic-medicine-verses-homoeopathic-medicine-with-biochemical-preparation-of-Natrum-phosphoricum-6x-in-gastro-oesophageal-reflux-disease.pdf – This randomized controlled trial (n=30) investigated the effect of Natrum phosphoricum 6X combined with homeopathic medicine versus homeopathic medicine alone in GORD patients. The study found a 42.19% improvement in the Natrum phosphoricum group compared to 65.77% in the control, suggesting no clear advantage. Limitations include small sample size and lack of reported statistical significance.
- https://weclinic.in/blog/natrum-phosphoricum-uses – This source provides traditional homeopathic uses for Natrum phosphoricum, including its role in neutralizing excess stomach acid and relieving associated burning sensations. It also mentions anecdotal claims regarding its aid in fat and protein digestion, and reduction of uric acid-related joint pain, though these lack robust clinical validation.
- https://hylands.com/products/hylands-nat-phos – This product page from Hyland's, a homeopathic manufacturer, details common dosing guidelines for Natrum phosphoricum 6X, recommending one tablet dissolved under the tongue three times daily. It also suggests increased frequency for acute symptoms, aligning with typical homeopathic practice.
- https://dailymed.nlm.nih.gov/dailymed/getFile.cfm?setid=9ad86f9f-df9e-4e5c-bce4-571e1da44145&type=pdf – This DailyMed entry, likely a product insert for a homeopathic preparation, provides dosing instructions for Natrum phosphoricum 6X, including recommendations for acute symptom management. It reinforces the sublingual administration method and general safety profile at homeopathic dilutions.
Supplements Containing Natrum phosphoricum

Calm Tablets
Hyland's

Cell Salt #10 Nat Phos 6X
Hyland's

Nerve Tonic
Hyland's

Nerve Tonic Tablets
Hyland's

Calms Forté Tablets
Hyland's

Calm Tablets
Hyland's

Nerve Tonic
Hyland's

Calms Forté Tablets
Hyland's

Calms Forté Tablets
Hyland's
Nerve Tonic
Hyland's Naturals

Nerve Tonic
Hyland's

Calms Forté Tablets
Hyland's