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Nitric Oxide Blend

Also known as: Nitric oxide boosters, NO precursors, Nitrates, L-arginine, L-citrulline, Nitric Oxide

Overview

Nitric oxide (NO) is a crucial signaling molecule with the chemical formula NO, playing a significant role in vascular relaxation and blood flow regulation. It is primarily derived from dietary nitrates found in foods such as beetroot, leafy greens, and various other vegetables. As a supplement, nitric oxide precursors like L-arginine and L-citrulline are often used to boost NO levels in the body. The primary applications of nitric oxide supplements include enhancing exercise performance, improving cardiovascular health, and increasing blood flow. However, the level of scientific research supporting these uses is moderate, with variable quality evidence concerning efficacy and safety, depending on the population studied and the specific outcomes measured.

Benefits

Nitric oxide supplementation is associated with several potential benefits. Evidence indicates that it may improve exercise performance, particularly in endurance sports, with some studies reporting ergogenic effects; approximately 46% of studies in one systematic review indicated benefits, although meta-analysis suggested trivial effects on aerobic performance. Additionally, nitric oxide is linked to cardiovascular health by promoting vasodilation, which may help lower blood pressure. These benefits appear especially relevant for individuals with conditions that reduce NO bioavailability, such as those with cardiovascular diseases. However, the overall effect sizes are generally small to moderate, with considerable variability across studies and more research needed to clarify long-term benefits.

How it works

Nitric oxide precursors like nitrates serve to enhance the production of NO in the body, thereby improving endothelial function and promoting vasodilation. This enhancement is primarily mediated through the enzyme endothelial nitric oxide synthase (eNOS), which converts L-arginine into nitric oxide. By improving vascular function, nitric oxide increases blood flow to muscles during exercise, potentially enhancing performance and reducing fatigue. The absorption of nitrates from dietary sources is efficient, further facilitating their conversion to NO in the system.

Side effects

Nitric oxide supplementation is generally considered safe for most individuals when used appropriately. However, some common side effects include gastrointestinal issues like diarrhea or stomach discomfort, affecting more than 5% of users. Less frequently, users may experience headaches or dizziness, with occurrences between 1-5%. Rare allergic reactions may occur in less than 1% of users. It is crucial to consider potential interactions with medications for hypertension and erectile dysfunction. Additionally, individuals with certain medical conditions or those taking specific medications should exercise caution. Pregnant and breastfeeding women are advised to consult healthcare providers before use.

Dosage

The typical effective dosage for nitric oxide supplementation tends to range from 300-500 mg of beetroot juice or equivalent nitrate content, with optimal dosages frequently cited between 500-1000 mg of beetroot juice or 5-10 mmol of nitrates. Users usually take these supplements about 1-3 hours prior to exercise for best results. While the upper limits of safe dosing aren't well established, it's advisable to avoid excessively high doses as they may increase unwanted side effects. Factors such as dietary intake and individual differences may influence absorption rates, impacting the effective dose required.

FAQs

How long does it take to see benefits?

Benefits are typically felt acutely but long-term effects are less clear due to variability in outcomes.

Is it safe for everyone?

Generally safe but caution is advised for those with specific medical conditions or on certain medications.

When should I take it?

It's usually recommended to take nitric oxide supplements prior to exercise for optimal effect.

What can I expect?

Users may observe improvements in exercise performance and cardiovascular health.

Does it work for everyone?

Effects can vary widely among individuals, so results may not be consistent.

Research Sources

  • https://www.mdpi.com/2072-6643/16/22/3832 – This systematic review assessed 22 studies focusing on ergogenic benefits of nitric oxide supplementation. While 46% of studies reported positive outcomes, the meta-analysis concluded with trivial overall effects on aerobic performance. Limitations included small sample sizes and considerable heterogeneity among studies.
  • https://pubmed.ncbi.nlm.nih.gov/36771366/ – This review discusses the potential of nitric oxide precursors, such as L-arginine and nitrates, in enhancing muscle performance through improved blood flow, though it emphasizes theoretical considerations without presenting specific empirical data.
  • https://www.mdpi.com/2227-9059/11/7/1859 – This meta-analysis explored beetroot and nitrate supplementation's impact on body composition, finding no significant effects on body composition indices but emphasizing the high-quality methodological approach and narrow focus.
  • https://www.science.gov/topicpages/l/lack+scientific+evidence – This source discusses the broader lack of robust scientific evidence for numerous supplement claims, highlighting the need for more rigorous testing and study designs, specifically in areas related to nitric oxide and performance enhancements.
  • https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/effects-of-beetroot-and-nitrate-supplementation-on-body-composition-a-gradeassessed-systematic-review-and-metaanalysis/949832E60B3818D6D849353FC0B117FE – A systematic review and meta-analysis evaluating beetroot and nitrate supplementation, which assessed body composition effects and stressed a moderate quality of evidence due to limited study designs and varying results among populations.

Supplements Containing Nitric Oxide Blend

Arnold Iron Pump Watermelon by MusclePharm
70

Arnold Iron Pump Watermelon

MusclePharm

Score: 70/100
N.O. Overload Pre-Workout Formula Pounding Punch Flavor by Hi-Tech Pharmaceuticals
78

N.O. Overload Pre-Workout Formula Pounding Punch Flavor

Hi-Tech Pharmaceuticals

Score: 78/100
Arnold Schwarzenegger Iron Pump Blue Razz by MusclePharm
63

Arnold Schwarzenegger Iron Pump Blue Razz

MusclePharm

Score: 63/100
Arnold Schwarzenegger Iron Pump Pineapple Mango by MusclePharm
63

Arnold Schwarzenegger Iron Pump Pineapple Mango

MusclePharm

Score: 63/100
Arnold Schwarzenegger Iron Pump Watermelon by MusclePharm
70

Arnold Schwarzenegger Iron Pump Watermelon

MusclePharm

Score: 70/100
Arnold Schwarzenegger Iron Pump Fruit Punch by MusclePharm
60

Arnold Schwarzenegger Iron Pump Fruit Punch

MusclePharm

Score: 60/100
Arnold Schwarzenegger Iron Pump Raspberry Lemonade by MusclePharm
68

Arnold Schwarzenegger Iron Pump Raspberry Lemonade

MusclePharm

Score: 68/100
Renewable Energy Pomegranate Berry & Beet Flavor by Ora
70

Renewable Energy Pomegranate Berry & Beet Flavor

Ora

Score: 70/100
PreWorkout Wild Berry by Ground-Based Nutrition
83

PreWorkout Wild Berry

Ground-Based Nutrition

Score: 83/100
Neo40 by HumanN
65

Neo40

HumanN

Score: 65/100
Rejuvenaid Pomegranate Citrus Flavor by Nature's Sunshine
70

Rejuvenaid Pomegranate Citrus Flavor

Nature's Sunshine

Score: 70/100
Superfood Beets Raspberry by Feel Great Vitamin Co.
70

Superfood Beets Raspberry

Feel Great Vitamin Co.

Score: 70/100

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