Notoginseng Root Extract
Also known as: Notoginseng, Chinese Ginseng, Sanqi, Panax notoginseng
Overview
Notoginseng root extract is obtained from *Panax notoginseng*, a plant widely utilized in traditional Chinese medicine for its healing properties, particularly related to cardiovascular health. The plant's active components, known as saponins, exhibit various therapeutic effects. Research on notoginseng is at a moderate level, with several clinical studies highlighting its potential benefits, although further investigations are necessary for confirmation of its efficacy in certain areas. Commonly consumed as a dietary supplement, notoginseng is available in various forms, including powders, capsules, and injectable preparations, and has become recognized for its anti-inflammatory and antioxidant properties.
Benefits
Notoginseng has been shown to improve clinical outcomes in cardiovascular conditions, notably in the treatment of acute myocardial infarction (AMI) and ischemic stroke. A meta-analysis indicated a significantly higher total effective rate when combining notoginseng saponins with standard treatments for AMI (odds ratio [OR] = 3.09, 95% CI: 1.67 to 5.72, *p* < 0.05). Additionally, a randomized controlled trial involving 3072 patients demonstrated improved functional independence in stroke patients after 3 months of treatment with notoginseng (89.3% versus 82.4%, OR = 1.95, 95% CI: 1.56-2.44, *p* < 0.001). Evidence also suggests its anti-inflammatory and antioxidant properties, although these effects require further human studies for validation.
How it works
Notoginseng saponins primarily function through anti-inflammatory, antioxidant, and antiplatelet mechanisms. These compounds enhance endothelial function and support vascular health by reducing inflammation and improving blood circulation. They specifically target vascular pathways, including platelet aggregation and endothelial nitric oxide synthase (eNOS), which is crucial for vasodilation. The bioavailability of notoginseng saponins differs among various compounds, with compound K exhibiting enhanced bioavailability compared to other parent saponins.
Side effects
Notoginseng is generally regarded as safe for most individuals when taken appropriately; however, long-term safety data is limited. The most commonly reported side effects are mild gastrointestinal disturbances. While rare, some users may experience allergic reactions, particularly if taking anticoagulant medications, due to the extract's potential antiplatelet effects. Severe allergic reactions are uncommon but possible. Caution is advised for individuals with bleeding disorders or those on anticoagulant therapy. Additionally, its use during pregnancy and breastfeeding is contraindicated due to the lack of sufficient safety data.
Dosage
The typical dosage of notoginseng saponins ranges from 250 mg to 500 mg per day, particularly for cardiovascular conditions, where doses are often standardized to ensure adequate active saponin content. While there is limited information on maximum safe doses, individuals should adhere to recommended guidelines to avoid adverse effects. Consistent daily administration is suggested for chronic health issues. Various forms of notoginseng are available, with injectable forms used in clinical settings and oral supplements more common for general use.
FAQs
Can I use notoginseng for cardiovascular health?
Yes, notoginseng is specifically used for cardiovascular benefits, especially for conditions like acute myocardial infarction and ischemic stroke.
Is it safe to use notoginseng continuously?
While generally safe in the short term, there is limited data on the long-term effects of notoginseng. Consultation with a healthcare provider is recommended.
How long does it take to see results?
Patients may observe benefits within weeks to months of consistent use, depending on the specific health condition.
Are there any known interactions with medications?
Yes, notoginseng may interact with anticoagulants due to its antiplatelet properties, necessitating caution and consultation with a healthcare professional.
Is notoginseng a substitute for traditional treatments?
No, notoginseng should not replace conventional medical treatments but can be used as an adjunctive option under medical supervision.
Research Sources
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1353662/full – A meta-analysis revealing that the addition of notoginseng saponin injection to conventional treatment significantly improved outcomes for patients with acute myocardial infarction, showing a higher total effective rate (OR = 3.09, *p* < 0.05).
- https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2806292 – In a randomized controlled trial with 3072 ischemic stroke patients, notoginseng saponins enhanced functional independence assessed at 3 months post-treatment (89.3% vs. 82.4%, OR = 1.95, *p* < 0.001).
- https://pubmed.ncbi.nlm.nih.gov/37833676/ – This review discusses the pharmacological properties of notoginseng saponins, highlighting their anti-inflammatory and antioxidant effects, though specific clinical trial data is scarce.
- https://www.mdpi.com/2072-6643/16/13/2120 – An overview of various studies on notoginseng focusing on its health benefits, specifically the extract's potential roles in cardiovascular health and related mechanisms of action.
Supplements Containing Notoginseng Root Extract
Re-Built Mass Vanilla Cake Batter
GNC Beyond Raw
Re-Built Mass Triple Chocolate Cake
GNC Beyond Raw
Re-Built Mass Strawberry Milkshake
GNC Beyond Raw
Re-Built Mass Cookies & Cream
GNC Beyond Raw
Ritual Peach Mango Twist
ANS Performance
SuperGreens + SuperFoods
California Gold Nutrition Superfoods
San Qi Alcohol Free
Hawaii Pharm
San Qi
Hawaii Pharm
Raw Tienchi
Plum Flower
Enzorb Digestive Enzymes
Sunwarrior
Pump Mango Sorbet
Alani Nu
PreFuel Orange Flavor
EnergyFirst