Notopterygium Root Extract
Also known as: Qiang Huo, Notopterygium Root, *Notopterygium incisum*
Overview
*Notopterygium incisum* is a plant utilized in traditional Chinese medicine, primarily for its root, known for its anti-inflammatory and analgesic properties. Traditionally, it has been used to treat conditions such as pain, fever, and inflammation, with emerging research indicating potential applications in treating neurological disorders. The root of *Notopterygium incisum* contains bioactive compounds, such as sesquiterpenes and phenolic acids, which are believed to be responsible for its medicinal properties. Although the amount of research available is still in the emerging phase, animal studies suggest significant efficacy; however, there is a noted absence of human clinical data to support these findings, indicating a need for further investigation in this area.
Benefits
Research indicates potential benefits of *Notopterygium incisum*, particularly in animal studies where it has been shown to reduce inflammation and may enhance cognitive functions in models of neurological disorders such as epilepsy and Alzheimer's disease. These studies present the herb as a promising candidate for individuals suffering from neurological conditions, although the strength of the evidence is primarily rooted in preclinical models rather than human trials. For example, studies have documented antioxidant properties that may lower oxidative stress markers while enhancing superoxide dismutase (SOD) levels. Due to the lack of human data, the clinical significance and effect sizes remain unquantified in humans, necessitating further research.
How it works
*Notopterygium incisum* is believed to reduce neuroinflammation by inhibiting the activation of glial cells, such as microglia and astrocytes, while simultaneously enhancing the body's antioxidant defenses. Interaction with the central nervous system suggests a potential to ameliorate cognitive impairments and reduce seizure severity. However, detailed mechanisms and specific molecular targets have not been elucidated in human studies, and absorption characteristics remain largely unacknowledged.
Side effects
Safety profiles for *Notopterygium incisum* indicate it is generally regarded as safe in traditional practices; however, empirical evidence from human trials is lacking. Common adverse effects have not been well documented primarily due to the absence of human study data. No uncommon or rare side effects have been specifically identified, and potential drug interactions have not been well investigated. Due to limited data, pregnant or breastfeeding women are advised to seek medical consultation before use. Overall, the safety remains inconclusive without further human research.
Dosage
No established dosing guidelines exist for *Notopterygium incisum* in humans. Animal studies, such as those utilizing doses around 1 g/kg/day, do not translate directly to human dosages, as optimal ranges remain undefined. Maximum safe dosages are also not established, and specific timing considerations for administration haven't been documented in available literature. Root extract is the typical form used, but factors regarding absorption and necessary co-factors have not been thoroughly investigated.
FAQs
Is *Notopterygium incisum* safe to use?
Generally considered safe based on traditional usage, but human safety data are limited.
What are the expected results from using *Notopterygium incisum*?
It may reduce inflammation and improve cognitive function; however, more research is needed for definitive claims.
Can I take *Notopterygium incisum* while on other medications?
Potential drug interactions have not been well-studied, so consult a healthcare provider before use.
What is the typical dosage for *Notopterygium incisum*?
There is no established human dosage; animal study doses around 1 g/kg/day exist, but human equivalencies are not defined.
Are there any contraindications for using *Notopterygium incisum*?
Contraindications are not well established, but pregnant or breastfeeding women should consult healthcare providers.
Research Sources
- https://www.eurekaselect.com/article/122323 – This article discusses the efficacy of *Notopterygium incisum* in alleviating conditions such as epilepsy through neuroinflammation reduction and enhanced antioxidant activity based on animal studies. It emphasizes the need for human trials to confirm these effects.
- https://jmla.pitt.edu/ojs/jmla/article/download/1223/1368 – Review of the phytochemical properties of *Notopterygium incisum* and its traditional uses, highlighting its potential therapeutic benefits but also noting the scarcity of clinical research.
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1168863/full – The study presents data on the biological effects of *Notopterygium incisum*, focusing on its potential to modulate inflammation and cognitive functions in animal models, underlining the need for further human studies.
- https://pubmed.ncbi.nlm.nih.gov/32293681/ – This PubMed entry details a study exploring the pharmacological actions of *Notopterygium incisum*, emphasizing its traditional use and highlighting areas for future research, especially in clinical settings.
- https://pubmed.ncbi.nlm.nih.gov/39094757/ – The paper provides a systematic analysis of the properties of *Notopterygium incisum* and reviews its therapeutic potentials, noting the predominance of animal research over human applications.