Organic Licorice
Also known as: Licorice, Sweet root, Liquorice, Gan Cao, Glycyrrhiza glabra
Overview
Licorice (Glycyrrhiza glabra) is a perennial herb native to Europe and Asia, notable for its sweet flavor and traditional medicinal properties. The root of licorice contains glycyrrhizin, which converts to glycyrrhetic acid in the body, contributing to its various therapeutic effects. Historically used across multiple cultures for its soothing, anti-inflammatory, and antimicrobial properties, licorice has been researched extensively. Studies indicate its utility in managing conditions like liver disease, gastrointestinal disorders, and skin issues. Common forms include extracts, teas, and powders, often marketed as dietary supplements in health stores. Licorice is recognized for its effectiveness and safety in wellness practices; however, cautions against prolonged use are advised due to associated risks.
Benefits
Licorice showcases multiple evidence-supported benefits. A meta-analysis involving 26 clinical trials revealed licorice supplementation significantly reduces weight (mean difference -0.433 kg) and body mass index (BMI) (-0.150 kg/m²), both at p < 0.001. Its active compounds contribute anti-inflammatory, antioxidative, and antimicrobial effects, particularly beneficial in treating liver disease and gastric disorders. Topical applications have been effective against pain and promote healing of recurrent oral lesions. Overweight individuals may see significant benefits from licorice regarding weight management, typically observable after several weeks to months. Research quality is high, affirming licorice's role in targeted health interventions.
How it works
Licorice's primary mechanism of action stems from glycyrrhetic acid, which inhibits the enzyme 11β-hydroxysteroid dehydrogenase. This inhibition leads to increased cortisol levels, imparting mineralocorticoid-like effects that underpin its anti-inflammatory and antioxidative properties. These interactions significantly influence the endocrine system, mimicking steroid hormones that help regulate blood pressure and electrolyte balance. Variations in glycyrrhizin's bioavailability can affect efficacy, highlighting the need for careful dosage considerations.
Side effects
Long-term consumption of licorice can lead to several adverse effects primarily associated with its mineralocorticoid-mimicking properties. Commonly reported side effects affecting over 5% of users include hypertension and hypokalemia. Other less frequent effects (1-5%) entail edema and fluid retention. Severe complications, including hypertension and cardiac issues, may occur, especially in vulnerable populations (less than 1%). Licorice can interact with diuretics and antihypertensive medications, posing additional risks to those with pre-existing hypertension. Pregnant and breastfeeding women should exercise caution due to potential developmental effects.
Dosage
The recommended effective dosage for licorice generally ranges from 100 to 300 mg of glycyrrhizin or licorice flavonoids daily. An acceptable daily intake is approximately 0.015 to 0.229 mg of glycyrrhizin per kg of body weight. Extended use beyond these parameters may increase the risk of adverse reactions like hypertension and hypokalemia. While specific timing for administration is not outlined, continuous monitoring for negative side effects during prolonged usage is essential. Licorice is primarily taken orally, with absorption factors potentially influencing its therapeutic efficacy.
FAQs
How long can I safely use licorice?
Chronic use should be monitored closely for adverse effects such as hypertension and hypokalemia.
Can I use licorice if I have high blood pressure?
No, individuals with hypertension should avoid licorice due to its potential to elevate blood pressure.
What are the risks of long-term licorice consumption?
Long-term use may lead to hypertension and hypokalemia, along with other mineralocorticoid-related effects.
Is there a best time to take licorice?
There are no specific timing recommendations, but continuous monitoring for adverse effects is essential.
Is licorice safe for everyone?
Licorice is not recommended for hypertensive patients and should be used cautiously in other populations.
Research Sources
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517002/ – This systematic review examined the effects of licorice on weight management and metabolic parameters. It concluded significant weight reduction and decrease in BMI, validating licorice's potential role in addressing overweight conditions.
- https://www.frontiersin.org/articles/10.3389/fphar.2021.678264/full – This study evaluated the pharmacological effects of licorice compounds, highlighting their anti-inflammatory, antioxidative, and antimicrobial properties. It emphasized licorice's clinical relevance in treating various disorders while underscoring safety concerns.
Supplements Containing Organic Licorice
Organic Smooth Move
Traditional Medicinals
EveryDay Detox
Traditional Medicinals
Smooth Move Chocolate
Traditional Medicinals
Peppermint Smooth Move Senna
Traditional Medicinals
Organic Throat Coat
Traditional Medicinals
Yerba Mate Chai Spice Mate
Guayaki Brand
Bedtime
Yogi
Recommended Articles
Boost Lung Health: Key Ingredients & Foods
Key ingredients like omega-3 fatty acids, vitamins, and certain herbs promote better lung function and respiratory health.
Avoid These Ingredients Before Surgery
Certain ingredients, especially supplements that affect blood clotting, should be avoided before surgery to prevent complications.
Unsafe Supplements in Pregnancy 2025
In 2025, new research has led to updates in pregnancy supplement safety guidelines, identifying specific unsafe supplements.
ACE Inhibitors & Supplements: A Guide
Certain supplements, especially potassium-rich ones and specific herbs like St. John's Wort, can interfere with ACE inhibitors.