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Quatrefolic

Also known as: Quatrefolic, (6S)-5-methyltetrahydrofolate glucosamine salt

Overview

Quatrefolic is a synthetic form of folate, specifically the glucosamine salt of (6S)-5-methyltetrahydrofolate, the biologically active form of folate. Unlike folic acid, Quatrefolic does not require enzymatic conversion to become active, making it potentially more effective for individuals with MTHFR polymorphisms or other metabolic impairments. It is used as a dietary supplement to support folate status, particularly in those with genetic predispositions affecting folate metabolism. Quatrefolic is characterized by its high water solubility and stability. While research is ongoing, current evidence suggests it can help maintain adequate folate levels, especially in populations with MTHFR polymorphisms. However, more independent, peer-reviewed studies are needed to fully assess its benefits and risks compared to traditional folic acid.

Benefits

Quatrefolic is primarily beneficial for providing a direct source of biologically active folate, bypassing the need for metabolic conversion, which can be impaired in some individuals, particularly those with MTHFR polymorphisms. It may help maintain adequate folate levels in these populations. While manufacturer-sponsored studies suggest advantages in bioavailability and stability, more independent peer-reviewed research is needed to confirm these benefits. Individuals with MTHFR polymorphisms may experience greater benefits due to its direct bioavailability. The clinical significance and effect sizes are not yet well-documented in peer-reviewed literature, but its immediate bioavailability is a key advantage.

How it works

Quatrefolic works by directly providing the active form of folate, (6S)-5-methyltetrahydrofolate, which participates in one-carbon metabolism, a crucial process for DNA synthesis and repair. It interacts with the methylation cycle and enzymes like MTHFR. Unlike folic acid, it doesn't require conversion by dihydrofolate reductase (DHFR), bypassing a step that can be inefficient in some individuals. Its high solubility and bioavailability allow for direct utilization in the central nervous system, cardiovascular system, and hematopoietic system, supporting various physiological functions.

Side effects

Quatrefolic is generally considered safe, but long-term studies are limited. Common side effects are not well-documented, but potential gastrointestinal upset has been reported as an uncommon side effect. Rare side effects are not currently reported. Drug interactions may occur with anticonvulsants and other folate-related medications. While no contraindications are explicitly reported, caution is advised in individuals with known hypersensitivity to folate derivatives. Pregnant women, individuals with MTHFR polymorphisms, and those with cardiovascular disease may benefit from its use, but should consult with a healthcare provider before starting supplementation.

Dosage

The minimum effective dose of Quatrefolic is not well-established in peer-reviewed literature. Optimal dosage ranges typically align with those recommended for folic acid supplements, such as 200-400 μg daily. The maximum safe dose is also not established. Quatrefolic can be taken with meals to enhance absorption, although its high solubility already promotes good bioavailability. It is available in various supplement forms. No specific cofactors are required for its absorption or utilization.

FAQs

How does Quatrefolic compare to folic acid?

Quatrefolic is the active form of folate, bypassing the need for conversion like folic acid. This may be beneficial for individuals with MTHFR polymorphisms. More research is needed to fully compare efficacy and safety.

Is Quatrefolic safe for long-term use?

Quatrefolic is generally considered safe, but long-term studies are limited. Consult with a healthcare provider before starting long-term supplementation to ensure it is appropriate for your individual needs.

When is the best time to take Quatrefolic?

Quatrefolic can be taken at any time of day. Taking it with meals may enhance absorption, but its high solubility ensures good bioavailability regardless of timing.

What results can I expect from taking Quatrefolic?

Quatrefolic is expected to improve folate status, particularly in individuals with impaired folate metabolism. This can support various physiological functions, including DNA synthesis and cardiovascular health.

Is Quatrefolic a natural form of folate?

No, Quatrefolic is a synthetic derivative designed for better bioavailability, especially in individuals with MTHFR polymorphisms. It is not a naturally occurring form of folate.

Research Sources

https://nutraceuticalbusinessreview.com/quatrefolic-authorised-as-food-nutritional-fortification-substance--135706 – This article discusses the authorization of Quatrefolic as a food and nutritional fortification substance. It highlights its approval for use in various food products, emphasizing its role in enhancing folate intake and addressing potential deficiencies in the population.
https://pubmed.ncbi.nlm.nih.gov/31517834/ – This study investigates the impact of folic acid supplementation on stroke risk in cardiovascular patients. The meta-analysis reveals that folic acid reduces stroke risk, but its effectiveness can be limited by genetic factors, suggesting a potential benefit of using Quatrefolic in individuals with MTHFR polymorphisms.
https://www.activeiron.com/wp-content/uploads/2021/08/White-paper-Quatrefolic.pdf – This white paper highlights Quatrefolic's advantages in bioavailability and stability compared to folic acid. It presents manufacturer-sponsored data supporting its enhanced absorption and utilization, suggesting it may be a more effective option for individuals with impaired folate metabolism. However, independent peer-reviewed research is needed to confirm these benefits.
https://www.ginecarefmc.com/wp-content/uploads/2021/01/Nota-Ovosicare-ENG_revisada.pdf – This document discusses the use of Quatrefolic in the context of fertility and pregnancy support. It emphasizes the importance of adequate folate levels for reproductive health and highlights Quatrefolic's potential to improve folate status in women planning to conceive or during pregnancy.
https://quatrefolic.com/quatrefolic-vs-folic-acid/ – This resource compares Quatrefolic and folic acid, emphasizing Quatrefolic's direct bioavailability and stability. It suggests that Quatrefolic may be a more effective option for individuals with MTHFR polymorphisms or other metabolic impairments that hinder the conversion of folic acid to its active form.