Red Clover Flower Extract
Also known as: Trifolium pratense, Red Clover, Purple Clover, Red Clover Flower Extract
Overview
Red clover flower extract is derived from *Trifolium pratense* and is a phytoestrogenic supplement. It is rich in isoflavones, such as biochanin A and genistein, which are similar in structure to estrogen. Primarily, it is used to alleviate menopausal symptoms, especially hot flashes. The extract is available in various forms, including capsules, tablets, and teas. Red clover is native to Europe and Asia and is now grown in many parts of the world. Research on red clover is moderately mature, with several systematic reviews and meta-analyses available. However, the quality of evidence varies due to heterogeneity among studies. It's important to note that while red clover is generally considered safe for short-term use, long-term safety data is limited, and caution is advised for individuals with estrogen-sensitive conditions.
Benefits
The primary benefit of red clover flower extract is the reduction of hot flashes in perimenopausal and postmenopausal women. A meta-analysis showed a significant reduction in the daily incidence of hot flashes with red clover isoflavones (WMD -1.73, 95% CI: -3.28 to -0.18, p = 0.0292). Another study reported a mean difference of -1.34 hot flashes per day compared to placebo (95% CI: -1.90 to -0.77, p < 0.00001) over 3-4 months. Secondary benefits may include positive effects on cardiovascular health by regulating blood glucose and lipid markers. Some evidence suggests potential anti-cancer properties when co-administered with standard drugs. The effect size for hot flash reduction is moderate, and clinical significance varies based on individual response and study quality. Benefits are typically observed within 3-4 months of use.
How it works
The isoflavones in red clover act as phytoestrogens, interacting with estrogen receptors (ERα and ERβ) in the body. This interaction can potentially alleviate menopausal symptoms by mimicking the effects of estrogen, although the effects are generally weaker than those of endogenous estrogen. Isoflavones are absorbed in the gut and metabolized into more active forms, such as genistein and daidzein. These compounds then bind to estrogen receptors, influencing the endocrine system. The mechanism involves modulating estrogen-sensitive pathways, which can help regulate body temperature and reduce the frequency and intensity of hot flashes.
Side effects
Red clover flower extract is generally considered safe for short-term use, but long-term safety data is limited. Common side effects include mild gastrointestinal disturbances. Uncommon side effects may include allergic reactions, although these are rare. Rare side effects include potential interactions with blood thinners or estrogen-sensitive conditions. It may interact with estrogen therapies or blood thinners. Contraindications include pregnancy, breastfeeding, and conditions sensitive to estrogen. Caution is advised in individuals with a history of breast cancer or endometrial cancer. It is important to consult with a healthcare provider before using red clover, especially if you have pre-existing medical conditions or are taking other medications.
Dosage
The minimum effective dose is typically around 40 mg of isoflavones per day. The optimal dosage range is 80 mg to 160 mg of isoflavones per day for menopausal symptom relief. The maximum safe dose is not well established, so caution is advised beyond 160 mg/day. Consistent daily dosing is recommended. Standardized extracts containing biochanin A may be more effective. Bioavailability may be enhanced with food intake. There are no specifically identified required cofactors. It is important to start with a lower dose and gradually increase it to assess tolerance and effectiveness.
FAQs
Is red clover flower extract safe?
Generally safe for short-term use, but consult a healthcare provider if considering long-term use or if you have estrogen-sensitive conditions.
When and how should I take red clover flower extract?
Take consistently once daily, preferably with meals, to enhance bioavailability and reduce potential gastrointestinal discomfort.
How long before I see results?
Reduction in hot flashes may be noticeable within a few months of consistent use, but individual results may vary.
Can red clover replace hormone replacement therapy (HRT)?
No, red clover is not a replacement for HRT. Its effects may vary widely among individuals, and it is generally weaker than HRT.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/33920485/ – This meta-analysis of eight trials involving postmenopausal women found that red clover isoflavones significantly reduced the daily incidence of hot flashes. The study highlights the potential of red clover as a natural alternative for managing menopausal symptoms, but also notes the heterogeneity among studies, suggesting the need for further research to confirm these findings.
- https://pubmed.ncbi.nlm.nih.gov/34392659/ – This systematic review examined various studies on the effects of red clover and found potential benefits for anti-cancer properties, cardiovascular health, and menopausal symptom relief. The review acknowledges limitations due to study heterogeneity and quality, indicating that more rigorous research is needed to fully understand and validate these effects.
- https://jamanetwork.com/journals/jama/fullarticle/2529629 – This meta-analysis of seven trials on red clover supplementation showed mixed results for hot flash reduction, with significant heterogeneity among studies. The findings suggest that while some women may experience relief from hot flashes with red clover, the overall evidence is not conclusive due to variability and risk of bias in the included studies.
- https://pubmed.ncbi.nlm.nih.gov/25074017/ – This study reported a mean difference of -1.34 hot flashes per day when compared to placebo (95% CI: -1.90 to -0.77, p < 0.00001) over 3-4 months. This research suggests that red clover extract can be effective in reducing the frequency of hot flashes in menopausal women.
- https://www.mdpi.com/1661-3821/4/3/26 – This review provides a comprehensive overview of the phytochemistry, pharmacology, and clinical applications of red clover. It highlights the potential of red clover isoflavones in managing menopausal symptoms and improving cardiovascular health, while also emphasizing the need for further research to fully elucidate its mechanisms of action and long-term safety.
Supplements Containing Red Clover Flower Extract

Ultra Menoease With BioResponse DIM
Douglas Laboratories

Lymphatic Drainage
Nature's Sunshine

Defend
Huge Nutrition

Menopause Care Alcohol Free
Hawaii Pharm

Red Clover Alcohol Free
Hawaii Pharm

Strong Bones Alcohol Free
Hawaii Pharm

Detoxall
Hawaii Pharm

Menopause Care
Hawaii Pharm

Red Clover
Hawaii Pharm

Strong Bones
Hawaii Pharm

Detox/Flush
Amazing Herbs

Fem Wellness +
Herbal Goodness
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