Red Sage Leaf Extract
Also known as: Red Sage, Danshen, Salvia miltiorrhiza
Overview
*Salvia miltiorrhiza*, commonly known as Red Sage or Danshen, is an herb native to China and Japan that has been utilized in Traditional Chinese Medicine (TCM) for centuries. It is primarily recognized for its cardiovascular health benefits but is also being investigated for its role in managing osteoporosis and other health conditions. This plant contains bioactive compounds such as tanshinones and salvianolic acids, which are believed to mediate its therapeutic effects. Current research indicates moderate evidence supporting its usage, with a growing number of preclinical studies and a limited number of clinical trials, emphasizing the need for more rigorous investigations to establish its efficacy and safety in various applications.
Benefits
Research suggests that *Salvia miltiorrhiza* may offer several health benefits, primarily its potential anti-osteoporotic effects by inhibiting osteoclastogenesis and promoting osteoblastogenesis. It is particularly observed to benefit patients with osteoporosis, especially when used alongside other herbs. Secondary effects include cardiovascular benefits owing to its antioxidant and anti-inflammatory properties. Some studies have shown significant improvements in bone density and reduced bone resorption, although results vary among individuals. Long-term use may be required to achieve noticeable benefits.
How it works
The mechanism of action for *Salvia miltiorrhiza* involves inhibiting the MAPK/NF-κB/NFATc1 signaling pathway, which helps reduce bone resorption, while also activating the Wnt/β-catenin/VEGF pathway that supports bone formation. These interactions suggest its role in influencing both bone metabolism and cardiovascular health, driven primarily by the bioactive compounds present in the extract, namely tanshinones and salvianolic acids.
Side effects
*Salvia miltiorrhiza* is generally considered safe for use; however, it can cause gastrointestinal side effects, including nausea and diarrhea. Less common adverse effects reported include dizziness and skin rashes. While rare side effects are not well documented, caution is advised due to potential interactions with anticoagulants, given its antiplatelet properties. Pregnant or breastfeeding individuals should avoid this supplement due to insufficient safety data. Additionally, patients with bleeding disorders should consult a healthcare provider before use.
Dosage
No well-established minimum effective dose is defined for osteoporosis management. Typically, the optimal dosage varies, especially since *Salvia miltiorrhiza* is often used in combination with other herbs. While maximum safe dosage is not clearly established, long-term usage of the extract is common. Given the variable bioavailability, using the extract form can aid absorption. It is recommended to consult with a healthcare professional for personalized dosing guidance.
FAQs
Is Red Sage safe for everyone?
Generally, it is safe when used appropriately; however, those pregnant or breastfeeding, or with bleeding disorders, should exercise caution.
How long does it take to see benefits?
Long-term use is often necessary to observe significant benefits, especially for bone health.
Can I take Red Sage with other medications?
Consult with a healthcare provider before combining it with other medications due to potential interactions.
What are the common side effects?
Common side effects include gastrointestinal issues like nausea and diarrhea, with rare instances of dizziness and skin rash.
Is Red Sage a substitute for prescription osteoporosis treatments?
No, it should not be considered a substitute for conventional osteoporosis treatments without further clinical evidence.
Research Sources
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1483431/pdf – This systematic review evaluated TCM clinical trials and found potential benefits of *Salvia miltiorrhiza* in managing osteoporosis, particularly in combination with other herbs, but noted limitations in study designs and control groups.
- https://www.science.gov/topicpages/d/databases+pubmed+cinahl – General database resource listing peer-reviewed literature related to *Salvia miltiorrhiza*, showcasing its varied applications in health and medicine.
- https://www.webmd.com/vitamins/ai/ingredientmono-504/sage – This overview discussed the health benefits of sage, providing context for the bioactive compounds found in *Salvia miltiorrhiza* and their effects on health, particularly cardiovascular functions.
- https://www.dec.gov.ua/wp-content/uploads/2019/11/global-evidence-summit-abstracts-2017.pdf – A collective analysis of herb-related health benefits, including *Salvia miltiorrhiza*, which delves into pharmacological actions and potential therapeutic applications.
- https://www.verywellhealth.com/add-flavor-and-lower-cholesterol-with-sage-4069887 – This article provided insights on the culinary and medicinal uses of sage, emphasizing its role in health, aligning with findings related to *Salvia miltiorrhiza*.
Supplements Containing Red Sage Leaf Extract
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