Red Wine Fruit Extract
Also known as: Red wine extract, Grape extract, Polyphenol extract, Red Wine Fruit Extract
Overview
Red wine fruit extract is derived from the skin and seeds of red grapes (Vitis vinifera), and is a rich source of polyphenols, including resveratrol, quercetin, and anthocyanins. These compounds are known for their antioxidant properties, making the extract a popular supplement for promoting cardiovascular health and overall well-being. It is primarily used for its potential to improve vascular health, reduce inflammation, and combat oxidative stress. The extract is available in various forms, such as capsules and tablets, and is often marketed as a natural way to obtain the benefits associated with red wine consumption without the alcohol content. While extensive research supports the benefits of red wine polyphenols, more specific studies focusing solely on red wine fruit extract are needed to fully elucidate its effects. The quality of available evidence ranges from moderate to high, with systematic reviews and meta-analyses providing a strong foundation for its potential health benefits.
Benefits
Red wine fruit extract, rich in polyphenols, offers several potential health benefits, primarily related to cardiovascular health. Studies have shown that red wine polyphenols can improve systolic blood pressure, with a reduction of approximately -2.6 mmHg (95% CI: [-4.8, -0.4]). These polyphenols also reduce inflammatory markers like ICAM-1 and TNF-α in healthy subjects. Additional benefits include improved vascular function and a reduced risk of atherosclerosis, although these effects are more pronounced in animal studies. Individuals at risk of cardiovascular disease may particularly benefit from red wine fruit extract, especially in reducing systolic blood pressure. While the effect size for blood pressure reduction is moderate, its clinical significance varies based on individual health status. Both acute and chronic effects have been observed, but consistent consumption is necessary for long-term benefits.
How it works
Red wine fruit extract exerts its effects through antioxidant and anti-inflammatory pathways. The polyphenols in the extract inhibit LDL oxidation and reduce the production of inflammatory cytokines like TNF-α. Resveratrol, a key component, targets pathways involved in nitric oxide production and platelet aggregation, thereby improving vascular function. The extract interacts with the cardiovascular system by enhancing endothelial function and reducing inflammation. While polyphenols have variable bioavailability, resveratrol's metabolites contribute to its overall effectiveness. These mechanisms collectively support the extract's potential to promote cardiovascular health and reduce the risk of related diseases.
Side effects
Red wine fruit extract is generally considered safe when consumed in moderation. Common side effects are rare, but high doses of polyphenols may cause gastrointestinal upset. Uncommon side effects include potential interactions with blood thinners due to the extract's antiplatelet effects. Rare side effects may include allergic reactions. The extract may interact with anticoagulants and certain medications metabolized by CYP3A4. It is contraindicated in pregnancy and breastfeeding due to a lack of specific safety data. Caution is advised for individuals with bleeding disorders or those taking anticoagulant medications. It is important to consult with a healthcare provider before using red wine fruit extract, especially if you have underlying health conditions or are taking other medications.
Dosage
While a minimum effective dose for red wine fruit extract is not well established, polyphenol doses often range from 100 to 500 mg per day. Studies typically use doses of 250-500 mg of polyphenols. A maximum safe dose has not been established, but high doses may cause gastrointestinal upset. Consistent daily intake is recommended for potential benefits. Capsules or tablets are common forms. Bioavailability can be enhanced by consuming the extract with fatty meals. No specific cofactors are required. It is important to adhere to recommended dosage guidelines and consult with a healthcare professional to determine the appropriate dosage for individual needs and health status.
FAQs
How often should I take red wine fruit extract?
Daily intake is recommended for consistent benefits in cardiovascular health and antioxidant support.
Is red wine fruit extract safe for everyone?
It is generally safe, but caution is advised for those with bleeding disorders, pregnant or breastfeeding women, and individuals taking anticoagulants.
Should I take it with food?
Yes, taking it with food, especially fatty meals, can enhance the absorption of polyphenols.
What benefits can I expect?
Potential benefits include improvements in cardiovascular health, reduced inflammation, and antioxidant protection.
Does red wine fruit extract contain alcohol?
No, the extracts are typically alcohol-free, providing the benefits of red wine polyphenols without the alcohol content.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/32303823/ – This systematic review and meta-analysis of 48 animal and 37 human studies found that red wine polyphenols improve systolic blood pressure and vascular function, particularly in animal models. However, human studies showed less consistent benefits compared to animal studies, indicating a need for more targeted research in human populations.
- https://academic.oup.com/eurheartj/article/28/14/1683/2887413?login=false – This meta-analysis, including 426 participants across 12 studies, revealed that red wine significantly decreases inflammatory markers in healthy subjects but not in those with cardiovascular disease. The studies ranged from 4 to 4 weeks, suggesting that red wine's anti-inflammatory effects are more pronounced in healthy individuals over a short duration.
- https://journals.lww.com/md-journal/fulltext/2024/06070/red_wine_alleviates_atherosclerosis_related.51.aspx – This review highlights that red wine polyphenols, especially resveratrol, have antioxidant and anti-inflammatory effects that are beneficial for cardiovascular health. It provides a comprehensive overview of the mechanisms and potential benefits of these compounds, supporting their role in reducing the risk of cardiovascular diseases.
Supplements Containing Red Wine Fruit Extract

Vivix
Shaklee

World Health
ProCaps Laboratories

Super Reds Mixed Berry Flavor
Country Farms

Red Wine Extract 500 mg
Swanson

Platinum Test Booster
MuscleTech Essential Series

Super Reds Berry Flavor
Country Farms

Super Reds Natural Cherry Flavor
Garden Greens

Resveratrol Maximum Strength
Purely Optimal

Advanced Digestive Support
DNA Miracles

Resveratrol Complex 500 mg
Lake Avenue Nutrition

Collagen Love
HUM Nutrition
Collagen COMPLETE with Health & Beauty Blend
Nature's Promise®
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