Relora Proprietary Blend
Also known as: Magnolia officinalis, Phellodendron amurense, honokiol, berberine, Relora
Overview
Relora is a proprietary blend derived from the bark extracts of Magnolia officinalis and Phellodendron amurense, traditionally utilized in Chinese medicine. It is standardized to ensure not less than 1.5% honokiol and 0.1% berberine, which are the key bioactive compounds believed to impart health benefits. Relora primarily aims to alleviate stress and anxiety, promoting improved mood states. Although research on Relora is still emerging, initial studies point towards its potential effectiveness for reducing temporary anxiety, cortisol levels, and other stress-related symptoms. Currently, clinical evidence for Relora is limited due to the absence of systematic reviews or comprehensive studies, making further research necessary to validate its benefits and mechanisms of action.
Benefits
Relora has demonstrated several evidence-based benefits, particularly in reducing transitory anxiety, salivary cortisol levels, and improving a variety of mood states, including tension, depression, and fatigue. In clinical trials, participants, particularly premenopausal women experiencing mild anxiety, benefited significantly, with mood state improvements observed as early as 4–6 weeks of supplementation. One study reported an 18% reduction in cortisol levels and marked improvements across various psychological parameters, suggesting moderate to significant clinical effects. However, the overall research quality is considered limited due to small sample sizes and the need for more comprehensive investigations.
How it works
The primary mechanism of action for Relora involves its bioactive constituents, honokiol and berberine, which potentially modulate the hypothalamic-pituitary-adrenal (HPA) axis, thereby reducing cortisol production in response to stress. This interaction positively influences the endocrine and nervous systems, leading to improvements in stress response and mood regulation. Although specific molecular targets remain unclear, Relora is thought to interact with neurotransmitter systems involved in mood disorders.
Side effects
The safety profile of Relora indicates no significant adverse effects reported in available studies. Common side effects (greater than 5%) were not identified, and no uncommon or rare side effects have been documented to date. Relora has not been associated with specific drug interactions; however, care should be taken when co-administering with medications that affect the HPA axis or neurological functioning. Although no contraindications are explicitly identified, pregnant or breastfeeding women and those with chronic medical conditions should consult health care professionals before starting supplementation. As with any herbal supplement, individual responses may vary, warranting caution in long-term use.
Dosage
The recommended dosage for Relora is approximately 750 mg per day, typically administered in divided doses of 250 mg each, taken three times daily. This is based on evidence from clinical studies. While the studies did not specify exact timing for administration, consistent daily intake is advisable to maintain stable bioactive compound levels. There are no established maximum safe doses, as the utilized dosages did not report adverse effects, but careful monitoring is suggested. Capsules containing the standardized extract are the preferred form of delivery, with absorption potentially influenced by dietary factors, although specific absorption data is limited.
FAQs
Is Relora safe to use?
Based on available studies, Relora appears to be safe, with no significant adverse events reported. However, individuals should remain cautious about long-term use and possible medication interactions.
When should I take Relora?
While there are no specific timing recommendations, consistent daily dosing is recommended for optimal results.
What benefits can I expect from Relora?
Users may expect reductions in temporary anxiety, decreased cortisol levels, and improvements in mood states, particularly within the first few weeks of use.
Can Relora replace medication for anxiety?
Relora is not intended as a replacement for traditional anxiety medications and may only offer relief for mild, transitory anxiety.
What is the optimal dosage for Relora?
The optimal dosage is around 750 mg daily, divided into three doses of 250 mg, based on available clinical studies.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/18426577/ – This study investigated the effects of a proprietary combination of Magnolia and Phellodendron extracts on anxiety levels in premenopausal women and found a reduction in temporary anxiety symptoms over a 6-week period.
- https://www.springermedizin.de/effect-of-magnolia-officinalis-and-phellodendron-amurense-relora/9593872 – This randomized controlled trial demonstrated that Relora significantly reduced salivary cortisol and improved mood parameters over four weeks among moderately stressed individuals.
- https://jmla.pitt.edu/ojs/jmla/article/download/1223/1368 – A systematic examination of various herbal supplements, highlighting the potential of Magnolia and Phellodendron extracts to influence stress and anxiety, yet emphasizing the need for further detailed research.
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