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Resistaid

Also known as: Larix decidua extract, Larix kaempferi extract, ResistAid, larch gum, Larch Arabinogalactan

Overview

Larch arabinogalactan is a polysaccharide derived from the bark of larch trees, specifically *Larix decidua* and *Larix kaempferi*. It is a dietary fiber supplement known for its immunostimulatory properties, which enhance immune function and possibly reduce the frequency of upper respiratory infections. As a prebiotic, larch arabinogalactan supports the growth of beneficial gut bacteria, particularly Bifidobacteria and Lactobacillus. Its safety is recognized by the FDA (GRAS), and it is typically available in powdered form. Although preliminary studies suggest beneficial effects on vaccine responses and immune health, including a reduction in cold episodes, the current body of research is limited, primarily featuring small sample sizes and short supplementation durations.

Benefits

Larch arabinogalactan is linked to several evidence-based benefits, particularly for immune support. Research indicates that it may reduce the incidence of common colds by 23% compared to placebo. Additionally, it shows promise in enhancing antibody responses to vaccines, specifically pneumococcal and tetanus vaccines, indicating potential improvements in vaccine efficacy. Most studies focus on healthy individuals, so effects in immunocompromised populations remain less understood. The effect size observed for cold symptom reduction is moderate, necessitating further studies to solidify clinical significance. Regular supplementation can yield noticeable benefits within weeks.

How it works

As a prebiotic, larch arabinogalactan promotes the growth of beneficial gut bacteria that play a crucial role in regulating immune responses. It primarily enhances populations of Bifidobacteria and Lactobacillus, which interact with gut-associated lymphoid tissue (GALT) to stimulate immune activity, including the enhancement of natural killer cells and macrophage function. Furthermore, it supports colon health by encouraging the production of short-chain fatty acids like butyrate. While its complete pharmacokinetics in humans are not fully established, it is fermented by gut microbiota, underscoring its prebiotic significance.

Side effects

Larch arabinogalactan is considered generally recognized as safe (GRAS) by the FDA, with minimal reported side effects. Mild gastrointestinal symptoms, such as bloating and flatulence, may occur, particularly with higher soluble fiber intakes, but no uncommon or serious adverse effects have been documented. Caution should be exercised among specific populations, including individuals with autoimmune disorders, tuberculosis, or those who are pregnant or lactating. Additionally, people on immunosuppressant medications should avoid the supplement due to its immunostimulant effects. Overall, while larch arabinogalactan is safe for most healthy individuals, those with compromised immune systems are advised to consult a healthcare provider before use.

Dosage

The typical recommended dosage of larch arabinogalactan ranges from 1 to 3 tablespoons per day, equating to approximately 4 to 15 grams. For optimal immune support, studies have shown that doses between 1.5 to 4.5 grams per day of the ResistAid extract are effective. It can be ingested with meals or mixed with water or juice to improve taste and mitigate potential gastrointestinal discomfort. Although absorption details remain limited, it is safe when consumed within the recommended ranges. No cofactors are specifically required for its absorption, but individual gut microflora may influence its prebiotic efficacy.