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Schizandra Extract

Also known as: Schisandra chinensis, Schisandra, Wu Wei Zi, Five Flavor Berry

Overview

Schisandra chinensis, also known as Wu Wei Zi or Five Flavor Berry, is a plant native to East Asia, valued for its berries rich in bioactive compounds like lignans and phenolic acids. Traditionally, it has been used to enhance vitality, mental clarity, and immune function. Modern applications explore its potential for improving exercise performance, combating fatigue, and promoting metabolic health. The plant exhibits antioxidant, anti-inflammatory, and adaptogenic properties. Research is ongoing, with increasing interest in its pharmacological effects, though the quality and consistency of evidence vary. Current findings suggest potential benefits in exercise and metabolic support, but further rigorous clinical trials are needed to establish its efficacy and safety across diverse applications.

Benefits

Schisandra chinensis offers several potential benefits, though the strength of evidence varies. Some studies suggest it may enhance exercise capacity and reduce fatigue, particularly in athletes. Preliminary evidence indicates a role in improving metabolic health, such as lowering blood glucose levels in diabetic models. Additionally, it exhibits immunomodulatory effects and may reduce inflammation. Its antioxidant properties contribute to overall health benefits. Individuals with metabolic disorders may also experience benefits, but further research is needed to confirm these findings and establish robust conclusions across diverse populations.

How it works

Schisandra chinensis modulates the MAPK and NF-κB signaling pathways, which are crucial for regulating inflammation and immune responses. It interacts with the immune, metabolic, and nervous systems, influencing various enzymes and receptors involved in these processes. While the exact mechanisms are not fully understood, its bioactive compounds are believed to have moderate bioavailability. Limited specific data is available on absorption rates, but it is thought to enhance the body's adaptive responses to stress.

Side effects

Schisandra chinensis is generally considered safe when used appropriately. Common side effects may include gastrointestinal upset and allergic reactions, occurring in more than 5% of users. Uncommon effects are not well-documented, with rare instances of severe allergic reactions reported (less than 1%). Drug interactions could occur with blood thinners and diabetes medications, necessitating caution. Its use is contraindicated during pregnancy and breastfeeding due to insufficient safety data. Individuals with severe allergies or those taking medications for diabetes or blood clotting should approach Schisandra chinensis with caution.

Dosage

Typical daily dosages of Schisandra chinensis range from 500 mg to 2 grams. Optimal dosages may vary depending on individual needs and the specific health benefit targeted, necessitating further research for accurate determination. While a definitive upper limit is not established, caution is advised beyond 2 grams per day. Taking it with meals may help mitigate potential gastrointestinal side effects. Common forms include capsules and extracts, and absorption may be enhanced when taken with fatty meals. No specific cofactors have been identified to improve its efficacy.