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Serinaid 50p Phosphatidylserine Powder

Also known as: Phosphatidylserine, PS, Serine

Overview

Phosphatidylserine (PS) is a phospholipid that is a crucial component of cell membranes, particularly in the brain, where it composes 5-10% of total lipids. It plays important roles in cellular processes such as neurotransmission, apoptosis, and synaptic refinements. PS is commonly used as a dietary supplement aimed at enhancing brain health and cognitive function, with potential applications in neurodegenerative and neurodevelopmental disorders such as Alzheimer's disease, Parkinson’s disease, major depressive disorder, and attention-deficit/hyperactivity disorder (ADHD). Available in various formulations, including softgels, capsules, and powders, PS is recognized for its safety and has been granted FDA Qualified Health Claims concerning cognitive functions. Research on PS is ongoing, yielding mixed results regarding its efficacy, necessitating further investigation with longer study durations to validate its effectiveness.

Benefits

Phosphatidylserine supplementation has been shown to support cognitive function, especially among older adults and individuals with mild cognitive impairment (MCI), where studies have indicated noteworthy improvements in short-term memory. In children with ADHD, a meta-analysis highlighted a statistically significant reduction in inattention symptoms with doses of 200-300 mg/day. Secondary benefits include potential stress reduction and neuroprotection due to its anti-inflammatory properties, although these findings require further validation. The optimal dosing for cognitive support is typically in the range of 100-300 mg per day, taken for periods of 2-6 months. While the evidence signals beneficial effects on cognitive health and specific ADHD symptoms, the overall quality of available studies ranges from low to moderate, with variables in outcomes due to short study durations and sample sizes.

How it works

Phosphatidylserine functions primarily by enhancing cell membrane fluidity and facilitating neurotransmitter release. It plays a key role in membrane signaling pathways and neuronal communication, impacting learning, memory, and language. PS binds to proteins integral to enzyme activation and influences inflammation regulation. Its capacity to cross the blood-brain barrier is essential in enhancing cognitive functions and mitigating neuroinflammatory responses.

Side effects

Phosphatidylserine is generally recognized as safe, with no commonly reported side effects in clinical studies. Serious adverse effects are rare, and no specific contraindications are known. While the supplement is considered well-tolerated in both children and older adults, mild gastrointestinal distress, insomnia, or headaches have been reported infrequently. As with any supplement, it is advisable for individuals—particularly those with underlying health issues—to consult healthcare providers before beginning PS supplementation. Additionally, drug interactions are considered limited, but caution should be practiced.

Dosage

The recommended dosage for phosphatidylserine typically ranges from 100 mg to 300 mg per day, dependent on the intended use. Effective doses for ADHD symptoms in children generally lie between 200-300 mg daily. It is suggested that dosing be divided across the day to optimize absorption, although there are no specific timing recommendations provided. There is currently no established maximum safe dosage, but exceeding 300 mg daily is less supported by clinical research. Softgels, capsules, and powdered mixes are common forms of PS supplement, suitable for various delivery methods.

FAQs

Is Phosphatidylserine safe?

Yes, Phosphatidylserine is generally recognized as safe and well-tolerated, with no significant side effects reported in clinical studies.

How should I take Phosphatidylserine?

It can be taken in doses of 100-300 mg per day, ideally divided throughout the day to enhance absorption.

What benefits can I expect?

Users may experience improvements in cognitive function, especially in memory and attention, although individual results can vary.

Can Phosphatidylserine be confused with other supplements?

Yes, Phosphatidylserine is often confused with other phospholipids like phosphatidylcholine, which serves different physiological roles.

Research Sources

https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2022.975176/full – This review discusses the role of Phosphatidylserine in cognitive health, anti-inflammation, and neuronal function, suggesting its potential as a therapeutic agent for central nervous system diseases.
https://examine.com/supplements/phosphatidylserine/ – An examination of Phosphatidylserine, summarizing its effects on cognitive function, dosing recommendations, and safety profile while evaluating the quality of research supporting these claims.
https://cheminutra.com/ingredients/serinaid/ – Details on the composition and use of Serinaid 50p Phosphatidylserine Powder, emphasizing its efficacy and applications in cognitive enhancement.
https://pubmed.ncbi.nlm.nih.gov/33539192/ – This randomized controlled trial analyzes the cognitive effects of Phosphatidylserine in patients with mild cognitive impairment, reporting improvements in memory and cognition.
https://pubmed.ncbi.nlm.nih.gov/39317299/ – A meta-analysis exploring the effects of Phosphatidylserine on ADHD symptoms, demonstrating statistically significant benefits in attentional deficits.