Get Your Personalized Supplement StackSupplement Stack Quiz

Serinaid Phosphatidylserine Complex

Also known as: PS, Phosphatidylserine Complex, Phosphatidylserine from Soy, Phosphatidylserine from Sunflower, Soy Lecithin Phosphatidylserine, Sunflower Lecithin Phosphatidylserine, Phosphatidylserine

Overview

Phosphatidylserine (PS) is a critical phospholipid predominantly found in neuronal cell membranes, playing a vital role in maintaining membrane integrity and functionality. Commonly sourced from plant-based origins such as soybeans and sunflower seeds, PS was historically extracted from animal tissues, but modern supplementation has transitioned to non-animal sources. Its significant impacts on cognitive health, particularly enhancements in memory, attention, and focus, make it a popular supplement. PS is also thought to aid in stress management and improve mood. It facilitates intercellular communication, neurotransmitter release, and supports healthy cell membrane dynamics. Notably, existing research indicates promising cognitive benefits, especially for older adults, although some studies highlight methodological limitations.

Benefits

Phosphatidylserine has multiple evidence-based benefits, predominantly in improving cognitive function where meta-analysis suggests a moderate effect size (SMD = 0.43), showing significant enhancements in memory and attention, especially in elderly populations. It may also aid in reducing stress by modulating cortisol levels, but further validation is necessary. Observations indicate neuroprotective effects, particularly beneficial during recovery from ischemic events. Children with ADHD have reported reduced attention deficits associated with supplementation. The overall quality of the supporting studies is high, with clinically relevant effects typically manifested within a few weeks of consistent use.

How it works

Phosphatidylserine functions primarily by preserving the structural integrity and fluidity of neuronal cell membranes, ensuring optimal cellular communication and neurotransmitter release associated with cognitive abilities. It also interacts with the endocrine system to modulate cortisol, thus influencing stress levels. Furthermore, it is involved in various cellular pathways related to cell survival and apoptosis, enhancing its neuroprotective properties, particularly under ischemic stress conditions.

Side effects

Phosphatidylserine is generally considered safe, particularly when derived from plant sources such as soy or sunflower. Common side effects experienced by over 5% of users may include mild gastrointestinal discomfort, such as nausea and upset stomach. Increased dosages may heighten these effects. Caution is advised for individuals with shellfish allergies using fish-derived PS, as rare severe gastrointestinal symptoms can occur at higher doses. Additionally, phosphatidylserine may interact with certain anticholinergic medications, potentially diminishing their efficacy. Pregnant and breastfeeding women should avoid supplementation without healthcare supervision due to insufficient safety data.

Dosage

The recommended daily dosage of phosphatidylserine varies between 100-200 mg for general cognitive support, with optimal effects generally observed at 200-300 mg daily. For specific benefits, such as improving cognitive attention in children with ADHD, higher dosages may be appropriate. Although no formal upper limit is established, excessive intake may lead to increased side effects. Phosphatidylserine can be taken with or without food, and users might consider timing their intake based on individual objectives, such as consuming it in the evening for stress management. Absorption may differ slightly depending on the source (soy vs. sunflower), yet it typically exhibits good bioavailability.

FAQs

Is phosphatidylserine safe for everyone?

Phosphatidylserine is generally safe when derived from approved sources; consult with a healthcare provider if you're pregnant, breastfeeding, or on other medications.

How should I take phosphatidylserine?

It can be consumed with or without food. Timing may depend on specific uses, such as taking it before bed for sleep-related stress.

When will I see results from phosphatidylserine?

Cognitive improvements, particularly in attention and memory, may become apparent after several weeks to a few months of consistent supplementation.

Is phosphatidylserine a cure for any medical condition?

No, phosphatidylserine is not a cure and should not replace medical treatments, serving instead as a supplement for cognitive health support.