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Setria Glutathione

Also known as: Glutathione (GSH), Setria Glutathione, Glutathione

Overview

Glutathione is a naturally occurring antioxidant found in cells, playing a crucial role in detoxification and reducing oxidative stress. It is synthesized from the amino acids cysteine, glycine, and glutamate. As a supplement, it is primarily used to enhance antioxidant defenses and potentially improve immune function. Glutathione neutralizes reactive oxygen species and participates in detoxification processes. Oral glutathione has low bioavailability, but certain formulations like Setria may improve absorption. Research on glutathione supplementation has shown mixed results regarding its efficacy in increasing overall glutathione levels in the body. It is available in various forms, including capsules, tablets, and liposomal formulations.

Benefits

Some studies suggest that glutathione supplementation can increase glutathione levels in the body, particularly in erythrocytes and plasma, although results are inconsistent. A randomized controlled trial indicated that daily consumption of GSH supplements increased glutathione levels in blood compartments. There is also evidence suggesting reduced oxidative stress and improved immune markers, such as increased natural killer cell activity. Benefits may vary by population, with some studies focusing on healthy adults. Increases in glutathione levels have been reported as 17-35% in some studies, though not all findings are statistically significant. Benefits may be dose and time-dependent, with effects observed after several months of supplementation.

How it works

Glutathione acts as an antioxidant by neutralizing reactive oxygen species (ROS) and participating in detoxification processes. It interacts with various body systems, including the immune system and liver detoxification pathways. Glutathione peroxidase is a key enzyme that utilizes glutathione to neutralize hydrogen peroxide. Oral glutathione has low bioavailability, but certain formulations like Setria may improve absorption. It supports immune function by promoting the activity of natural killer cells and other immune cells. Glutathione also plays a role in the metabolism of toxins and the maintenance of cellular redox balance.

Side effects

Glutathione supplementation is generally considered safe, though long-term effects are not well-studied. Common side effects may include temporary gastrointestinal discomfort. Uncommon and rare side effects are not well-documented. Potential interactions with medications that affect liver function or antioxidant pathways should be considered. Caution is advised in pregnancy and lactation due to limited data. Individuals with severe liver or kidney disease should also exercise caution. It is important to consult with a healthcare provider before starting glutathione supplementation, especially if you have any underlying health conditions or are taking medications.

Dosage

The minimum effective dose of glutathione is around 250 mg/day. Optimal dosage ranges are typically between 250-1,000 mg/day. The maximum safe dose has not been definitively established, but doses above 1,000 mg/day are less commonly studied. Consistent daily dosing is recommended. Liposomal formulations may enhance bioavailability. Food intake may affect absorption; taking glutathione on an empty stomach is often recommended. Selenium may enhance glutathione peroxidase activity, so ensuring adequate selenium intake may be beneficial.

FAQs

When is the best time to take glutathione?

It is often recommended to take glutathione on an empty stomach to potentially enhance absorption. Consistent daily dosing is also advised for optimal results.

Is glutathione supplementation safe?

Glutathione is generally considered safe, but long-term effects are not well-studied. Consult with a healthcare provider before starting supplementation, especially if you have underlying health conditions.

What are the expected results from taking glutathione?

Glutathione supplementation may increase glutathione levels and reduce oxidative stress, though results can vary. It's important to manage expectations and understand individual responses may differ.

Are there any misconceptions about glutathione?

A common misconception is that it can significantly increase body glutathione levels in all individuals. Absorption and efficacy can vary based on formulation and individual factors.

Research Sources

https://ph04.tci-thaijo.org/index.php/JCST/article/view/6734 – This randomized controlled trial with 54 non-smoking adults over 6 months found that glutathione supplementation increased glutathione levels in blood compartments. The study's limitations include its sample size and potential conflict of interest, though it used a high-quality methodology.
https://pubmed.ncbi.nlm.nih.gov/24791752/ – This systematic review and meta-analysis of five primary studies found no significant increase in glutathione levels in erythrocytes or plasma. The study's limitations include a high risk of bias in some of the included studies, resulting in a moderate quality assessment.
https://www.innerbody.com/best-glutathione-supplement – This review of branded glutathione formulations suggests that Setria and Opitac formulations may improve absorption. It is not a primary research study but is useful for product comparison, though it lacks primary data.
https://pubmed.ncbi.nlm.nih.gov/33218130/ – This study investigates the effects of glutathione supplementation on various health outcomes. It provides insights into the potential benefits and limitations of glutathione supplementation based on current research.
https://www.mdpi.com/2076-3921/9/11/1146 – This research explores the role of glutathione in cellular processes and its impact on overall health. It offers a comprehensive overview of glutathione's functions and its potential therapeutic applications.