Shi Shi Extract
Also known as: Shi Shi Extract, Shi Shi Extract (Unidentified)
Overview
Shi Shi Extract is a term found in traditional Chinese medicine (TCM) contexts, though it does not correspond to a clearly defined botanical species or chemical compound in scientific literature. Research indicates it is likely a component of multi-herbal formulations used in TCM external therapies (SETCM), rather than a standalone ingredient. These external applications often involve topical use or acupoint application. While direct studies on "Shi Shi Extract" are absent, broader systematic reviews on TCM external therapies suggest potential applications in conditions like dysphagia following stroke and general pain management. The research maturity level for "Shi Shi Extract" specifically is very limited, with no direct randomized controlled trials (RCTs) or meta-analyses focusing solely on this extract. Evidence regarding its benefits and safety is derived indirectly from studies on the broader category of TCM external therapies, which are generally considered to have moderate quality evidence but lack specificity for individual components.
Benefits
While no direct evidence exists for "Shi Shi Extract" as a standalone ingredient, systematic reviews of broader Traditional Chinese Medicine (TCM) external therapies, which may include components referred to as "Shi Shi Extract," suggest potential benefits. One meta-analysis indicated that specific external TCM therapies significantly improved clinical cure rates for dysphagia (difficulty swallowing) in post-stroke patients, showing an odds ratio of 2.36 (95% CI: 1.84–3.02, p < 0.00001) compared to control groups. This suggests a moderate to strong effect in this specific population. Another meta-analysis on Chinese herbal medicine interventions, which could encompass such extracts, demonstrated significant reductions in pain scores (SMD = −2.23, 95% CI: −3.04 to −1.41, p < 0.05). These findings suggest that formulations containing "Shi Shi Extract" might be beneficial for stroke patients with dysphagia and individuals experiencing pain. However, the strength of evidence for "Shi Shi Extract" itself is low due to the lack of ingredient-specific studies, and the observed benefits are attributed to complex multi-herbal interventions.
How it works
The specific mechanism of action for "Shi Shi Extract" as a standalone ingredient is currently unknown and not elucidated in scientific literature. However, within the context of Traditional Chinese Medicine (TCM) external therapies, which may incorporate such extracts, the proposed mechanisms are thought to involve local physiological responses. These could include modulation of local circulation, stimulation of nerve endings, or anti-inflammatory effects at the site of application. When used for conditions like post-stroke dysphagia or pain, these therapies are believed to interact with the nervous and musculoskeletal systems. The exact biological pathways, molecular targets, and absorption/bioavailability of "Shi Shi Extract" remain unidentified, as research has focused on the effects of complex herbal formulations rather than isolated components.
Side effects
The safety profile of "Shi Shi Extract" as a distinct ingredient is not established due to a lack of specific research. Systematic reviews on broader Traditional Chinese Medicine (TCM) external therapies, which might contain "Shi Shi Extract," generally report no major safety concerns or common side effects. However, this general safety assessment does not provide specific data for "Shi Shi Extract" in isolation. There are no documented common, uncommon, or rare side effects directly attributed to this extract. Furthermore, information regarding potential drug interactions, contraindications, or specific considerations for special populations (e.g., pregnant women, children, individuals with pre-existing conditions) is entirely absent. Users should exercise caution and consult a healthcare professional, especially given the unidentified nature of the extract and the lack of specific safety data. Any adverse reactions should be reported.
Dosage
Specific dosing guidelines for "Shi Shi Extract" are not established, as it is not a clearly defined or isolated ingredient in scientific literature. There is no information available regarding minimum effective doses, optimal dosage ranges, or maximum safe doses. Similarly, timing considerations for administration are not specified. Based on its presumed use within Traditional Chinese Medicine (TCM) external therapies, it is likely intended for topical or external application rather than internal consumption. Factors influencing absorption or cofactors that might enhance its effects are also undocumented. Without clear identification and specific research, it is impossible to provide evidence-based dosage recommendations. Any use should be under the guidance of a qualified TCM practitioner, who would typically incorporate it as part of a broader, multi-ingredient formulation.
FAQs
Is "Shi Shi Extract" effective alone?
No direct evidence supports the efficacy of "Shi Shi Extract" as a single agent. Reported benefits are associated with broader Traditional Chinese Medicine (TCM) external therapies, which are complex multi-herbal formulations.
Is it safe?
Specific safety data for "Shi Shi Extract" is lacking. However, the broader category of TCM external therapies, which may contain it, is generally considered safe when administered under professional guidance.
How long does it take to see effects?
The time course for observing effects from "Shi Shi Extract" is not specified. Benefits observed in studies of TCM external therapies varied depending on the specific condition and treatment duration.
Is "Shi Shi Extract" used internally or externally?
Evidence suggests that "Shi Shi Extract" is likely used in external applications within the context of Traditional Chinese Medicine therapies, such as topical or acupoint applications.
Research Sources
- https://www.frontiersin.org/article/1635090 – This meta-analysis investigated the efficacy of specific external Traditional Chinese Medicine (SETCM) therapies for post-stroke dysphagia. It found that SETCM significantly improved clinical cure rates compared to controls (OR = 2.36), suggesting a beneficial effect of these complex interventions on swallowing function in stroke patients. The study highlights the potential of external TCM approaches but does not isolate the effects of individual components like "Shi Shi Extract."
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1072991/full – This systematic review and meta-analysis examined the effectiveness of Chinese herbal medicine interventions for pain management. It concluded that these interventions led to significant reductions in pain scores (SMD = −2.23) compared to control groups. While demonstrating the potential of herbal medicine in pain relief, the study noted high heterogeneity among interventions and did not provide ingredient-specific analysis for components like "Shi Shi Extract."
- https://onlinelibrary.wiley.com/doi/10.1155/2019/2915498 – This systematic review and meta-analysis focused on the effects of corn silk tea combined with antihypertensive drugs on blood pressure. It suggested that this combination might be more effective than antihypertensive drugs alone in lowering blood pressure. However, the study's methodological quality was noted as poor, and its findings are not directly relevant to the efficacy or safety of "Shi Shi Extract."
Supplements Containing Shi Shi Extract
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