Soy Natto Extract
Also known as: Natto, Fermented Soybean Extract, Nattokinase
Overview
Natto is a traditional Japanese food made from fermented soybeans, primarily containing nattokinase, an enzyme known for its fibrinolytic properties, which means it can break down fibrin in blood clots. It is commonly consumed for its potential health benefits, particularly in enhancing cardiovascular health and reducing the risk of blood clots. With a moderate level of research maturity, various clinical studies and systematic reviews have assessed natto’s effects, demonstrating its significant impact, particularly on blood pressure regulation and cardiovascular disease prevention. Nattokinase is available in multiple forms, including natto as a food item and as dietary supplements in capsule or tablet preparations, offering versatile dietary options for those seeking its health benefits.
Benefits
Nattokinase is primarily associated with cardiovascular health improvements. A systematic review indicated that it can significantly lower systolic blood pressure (MD = -3.45, p < 0.00001) and diastolic blood pressure (MD = -2.32, p < 0.00001), making it valuable for hypertension management. Furthermore, population-based evidence links fermented soy intake, including natto, to reduced all-cause mortality rates and decreased cardiovascular disease-related mortality. Additional benefits observed include a potential decrease in the risk of type 2 diabetes due to overall soy consumption. Research quality is robust, comprising systematic reviews and randomized controlled trials, confirming natto's effectiveness in various populations, particularly in reducing cardiovascular-related risks.
How it works
Nattokinase works by breaking down fibrin, a protein essential for blood clot formation. This enzymatic activity enhances the body's fibrinolytic activity, promoting the dissolution of existing blood clots and potentially preventing new ones, thereby reducing the risk of thrombotic events. Its primary interactions are with the cardiovascular system, as it influences clot formation and dissolution, contributing to overall circulatory health.
Side effects
Nattokinase supplementation is generally considered safe, with studies indicating no significant adverse effects reported. Common side effects (>5%) were not noted, while uncommon effects (1-5%) and rare side effects (<1%) are also unreported. However, there is a known potential for interaction with anticoagulant medications due to nattokinase's fibrinolytic activity, requiring caution and medical supervision for individuals taking such medications. Pregnant or breastfeeding women, and those with bleeding disorders, should consult healthcare providers before use, underscoring the need for careful consideration of individual health circumstances.
Dosage
Effective dosing guidelines for nattokinase typically range from 2,000 to 4,000 fibrinolytic units (FU) per day, though the minimum effective dose is not firmly established. Optimal dosages may vary depending on individual health goals, particularly for cardiovascular benefits, suggesting a daily intake for sustained effects. There is no specified maximum safe dosage reported within existing studies. It is recommended that nattokinase be consumed consistently, potentially with food to enhance absorption, though definitive absorption factors remain under-studied.
FAQs
Is nattokinase safe for everyone?
Nattokinase is generally safe, but those on anticoagulant therapy or with bleeding disorders should consult a healthcare professional before use.
When should I take nattokinase?
While there are no specific timing recommendations, consistent daily intake is likely necessary to achieve sustained benefits.
What results can I expect from using nattokinase?
Regular use may lead to reductions in blood pressure and favorable outcomes related to cardiovascular health.
Can I replace my medications with nattokinase?
Nattokinase should not replace prescribed medications, and it’s important to use it under medical supervision, especially when on other treatments.
Research Sources
- https://www.bmj.com/content/368/bmj.m34 – This population-based cohort study involving 92,915 participants over 14.8 years found that intake of fermented soy products, including natto, was inversely associated with all-cause and cardiovascular disease-related mortality.
- https://pubmed.ncbi.nlm.nih.gov/39076715/ – A systematic review and meta-analysis assessing nattokinase supplementation concluded that it significantly reduced both systolic and diastolic blood pressure while reflecting on mixed effects on lipid profiles across six studies with 546 participants.
- https://pubmed.ncbi.nlm.nih.gov/35803164/ – The systematic review and meta-analysis synthesize multiple studies indicating that consumption of soy, including natto, is negatively associated with the risk of developing type 2 diabetes and cardiovascular diseases.
Supplements Containing Soy Natto Extract
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