Soy Seed Extract
Also known as: Soy Extract, Isoflavone Supplements, Genistein, Daidzein, Soy Isoflavones
Overview
Soy seed extract, derived primarily from soybeans, contains active compounds called isoflavones, notably genistein and daidzein, classified as phytoestrogens. It is widely used for various health benefits, particularly in alleviating menopausal symptoms such as hot flashes and night sweats. Additional purported benefits include potential improvements in bone and cardiovascular health. Variances in isoflavone concentrations depend on the source and processing of the soybeans. The body of research supporting its use is considerable, featuring numerous systematic reviews and meta-analyses that confirm its efficacy in specific health outcomes, primarily among perimenopausal and postmenopausal women. However, the evidence regarding its effects on other health conditions remains inconsistent.
Benefits
Soy isoflavones have demonstrated significant effectiveness in reducing the frequency of hot flashes by 20.6% and severity by 26.2% compared to placebo, according to systematic reviews and meta-analyses. The strongest evidence supports their use in perimenopausal and postmenopausal women. Evidence around bone health markers is more mixed; while a notable reduction in serum CTX levels indicates potential benefits, overall findings are inconsistent. The duration of observed benefits for hot flashes typically ranges from 6 weeks to 12 months, making it a viable option for improving quality of life in affected populations. These findings come from high-quality studies, emphasizing the importance of soy isoflavones in managing menopausal symptoms.
How it works
Isoflavones, particularly genistein and daidzein, function as phytoestrogens by binding to estrogen receptors ERα and ERβ in the body. This interaction mimics some estrogen effects, modulating physiological processes including thermoregulation and bone metabolism. Through these mechanisms, soy isoflavones can help alleviate menopausal symptoms and potentially support bone health. Additionally, their bioavailability can be influenced by individual metabolic factors and the form of the supplement used.
Side effects
Soy isoflavones are generally considered safe for short- to medium-term use. Common side effects occurring in over 5% of users include gastrointestinal issues such as bloating and stomach discomfort. Less common side effects, affecting 1-5% of users, can include headaches and allergic reactions. Rarely (<1%), adverse responses might occur, particularly concerning interactions with medications metabolized by liver enzymes, such as blood thinners and certain antidepressants. Caution is advised for women with a history of estrogen-sensitive cancers, and for pregnant or breastfeeding women, as safety is not well established in these groups.
Dosage
For alleviating hot flashes, a median effective dose of 54 mg of isoflavones (aglycone equivalents) daily has shown benefits. Typical dosage ranges from 50 mg to 100 mg of isoflavones per day are commonly used in research. While no formal maximum safe dosage is established, ongoing studies predominantly focus on doses at or below 100 mg. Consistent daily intake is recommended for maintaining therapeutic effects. The form of the supplement (extract vs. soy protein) may also influence efficacy, with extracts potentially being more potent. Factors affecting absorption should be acknowledged, including the presence of other nutrients.
FAQs
How long does it take to see benefits?
Benefits on hot flashes can be observed within 6 weeks to 12 months.
Are there any interactions with medications?
Yes, potential interactions with blood thinners, diabetes medications, and certain antidepressants.
Can I use it if I have a history of cancer?
Consult your healthcare provider, especially if you have a history of estrogen-sensitive cancers.
Is soy isoflavones safe for long-term use?
Generally safe for short- to medium-term use; long-term safety data is limited.
What are the expected results?
Reduction in hot flash frequency and severity, with potential benefits on bone health markers.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/22433977/ – This systematic review and meta-analysis involving 19 trials found that soy isoflavone supplements significantly reduced hot flash frequency and severity among perimenopausal and postmenopausal women, providing high-quality evidence following Cochrane guidelines.
- https://pubmed.ncbi.nlm.nih.gov/35803164/ – This systematic review showed mixed effects of soy isoflavones on bone turnover markers in postmenopausal women, indicating some beneficial outcomes but high variability in study results.
- https://www.mdpi.com/1660-4601/18/10/5346 – In this systematic review, the analysis of several trials demonstrated no significant long-term effects on serum uric acid levels from soy isoflavine interventions, emphasizing the heterogeneity in study findings.
- https://libguides.usc.edu/healthsciences/systematicreviews/databases – A resource guide detailing the use of systematic reviews across various health topics, including methodologies that inform evidence synthesis.
- https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.975718/full – This research article discusses novel findings about dietary soy isoflavones, reinforcing their role as potential dietary supplements benefitting health outcomes primarily in menopausal symptoms management.
Supplements Containing Soy Seed Extract
Recommended Articles
Herbal Boosters & COVID-19 Antivirals: Safe Mix?
Herbal supplements may interact with COVID-19 antivirals, requiring careful consideration and further research.
Top Immune Support Ingredients: What Works?
Vitamin D, zinc, and echinacea are key ingredients in immune support supplements, backed by scientific evidence.
Top Anti-Inflammatory Supplement Ingredients
Curcumin, omega-3 fatty acids, CBD, and Vitamin D are proven to effectively reduce chronic inflammation.
Best Supplements for Cortisol Reduction: A Scientific Guide
Adaptogens like Ashwagandha and Rhodiola, along with Phosphatidylserine, are effective in reducing cortisol levels, supported by scientific studies.