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Spilanthes

Also known as: Toothache plant, Paracress, *Spilanthes acmella*

Overview

*Spilanthes acmella* is a flowering plant indigenous to tropical regions, favored in traditional medicine for its analgesic and anti-inflammatory properties. The plant is renowned for its bioactive compounds, particularly N-alkylamides, which may influence hormone levels and pain perception. Although it is primarily used within Ayurvedic practices, the body of research on its efficacy is still developing, with many studies focused on animal models and limited human trials. As such, while its applications are promising, they are not fully supported by high-quality evidence from large-scale human studies.

Benefits

The potential benefits of *Spilanthes acmella* include a possible increase in testosterone levels, especially in young men; however, evidence remains mixed, with some studies indicating significant variations among individuals. Additionally, it showcases analgesic and anti-inflammatory effects, which cluster around pain management. The strongest evidence currently stems from small-scale randomized controlled trials, yet the variability in effect size and the lack of large cohort studies emphasize the need for further research to solidify these claims.

How it works

*Spilanthes acmella* may exert its effects via mechanisms involving hormone regulation, particularly related to testosterone levels, and influencing pain perception pathways. The biocompound N-alkylamides is thought to interact with various targets in the endocrine system. However, comprehensive understanding of its absorption and bioavailability remains undeveloped, necessitating additional study.

Side effects

Overall, *Spilanthes acmella* is generally deemed safe, with side effects largely undocumented due to the limited nature of human research. Specific risks involve potential interactions with hormonal therapies. Caution is particularly advised for individuals who are pregnant or breastfeeding due to inadequate safety data. There is also concern for those with hormonal imbalances, warranting attentiveness to individual responses in these populations. Uncommon and rare side effects have not been reported, reflecting a need for more rigorous investigations into the safety profile of this herb.

Dosage

While optimal dosage ranges for *Spilanthes acmella* have not been firmly established, it is commonly administered in extracts and capsules, and the effective doses can vary widely. Conclusive recommendations for timing or specific forms of administration are yet to be defined. Additionally, maximum safe doses are not outlined, indicating a lack of consensus in the available literature. Hence, further studies are required to establish clearer dosing guidelines.

FAQs

Is *Spilanthes acmella* safe to use?

Generally, yes, but safety data is limited, especially during pregnancy and breastfeeding.

What are the expected results from using this herb?

Results can vary; some individuals may experience increased testosterone levels, but effects are not universally experienced.

What dosage should I take?

Dosage is not firmly established, with extracts commonly used—consult a healthcare provider for recommendations.

Are there any known side effects?

Common and rare side effects have not been well-documented; caution is advised when combining with hormonal therapies.

Can I use *Spilanthes acmella* if I have hormonal imbalances?

Caution is advised if you have hormonal imbalances; consult with a healthcare professional.

Research Sources

https://www.memphis.edu/nutraceutical/pdfs/6-2016-jbls-spilanthes.pdf – This randomized controlled trial explored the effects of *Spilanthes acmella* on testosterone levels in young males, revealing no significant overall increase, yet a noteworthy rise among a subset of participants.
https://primerascientific.com/psmph/volume-3-issue-5 – This review provides insights into the therapeutic potential of *Spilanthes acmella*, highlighting both its aphrodisiac properties and its possible effects on testosterone.
https://www.researchgate.net/publication/281734528_High_therapeutic_potential_of_Spilanthes_acmella_A_review – This article reviews the therapeutic potential of *Spilanthes acmella*, noting promising effects in animal studies though emphasizing the need for further human research.
https://www.mdpi.com/1660-4601/18/7/3532 – The findings in this study discuss the efficacy of *Spilanthes acmella* in a broader context, primarily focusing on its various pharmacological actions and traditional uses.
https://www.researchgate.net/publication/368754676_Effect_of_SA3X_Spilanthes_acmella_Supplementation_on_Serum_Testosterone_Levels_in_Males_with_Erectile_Dysfunction_-_A_Parallel_Double-Blind_Randomized_Controlled_Trial – This research assesses the impact of *Spilanthes acmella* supplementation on testosterone levels in men with erectile dysfunction, contributing to the small body of literature surrounding its efficacy.