Stinging And Dwarf Nettle Extracts
Also known as: Urtica dioica, Stinging nettle, Dwarf nettle
Overview
Urtica dioica, commonly known as stinging nettle, is a herbaceous perennial plant found worldwide. It is characterized by stinging hairs containing chemicals like acetylcholine and serotonin. The root is primarily used to treat benign prostatic hyperplasia (BPH) and associated lower urinary tract symptoms (LUTS), while the leaves are used for conditions like arthritis and allergies. Stinging nettle is rich in fiber, minerals, vitamins, and antioxidants, exhibiting anti-inflammatory, antioxidant, and antiproliferative properties. Research on stinging nettle is moderate, with systematic reviews and meta-analyses supporting its use in BPH. It is available in various forms, including capsules, teas, and topical applications. More high-quality trials are needed to fully assess its efficacy and safety for various conditions.
Benefits
The most robust evidence supports the use of *Urtica dioica* in men with BPH. A meta-analysis showed significant improvements in the International Prostate Symptom Score (IPSS), peak urinary flow rate (Qmax), and reduced prostate volume. Some evidence suggests benefits in diabetes management, with a meta-analysis showing a significant reduction in fasting blood sugar (FBS) concentrations in individuals with type 2 diabetes. There is also some evidence suggesting benefits in arthritis relief and reduction in seasonal allergies, but more research is needed to confirm these effects. The effect sizes for BPH symptoms are significant, with a standardized mean difference (SMD) indicating substantial improvement in IPSS, Qmax, and prostate volume.
How it works
Stinging nettle extracts may act through anti-inflammatory and antiproliferative pathways, contributing to its benefits in BPH and other conditions. The root extracts may affect the prostate gland by inhibiting the growth of prostate cells and improving urinary flow. The leaves may have systemic effects such as reducing inflammation and improving antioxidant status. The extracts contain compounds that can interact with Na+,K+-ATPase in the prostate, which may help in reducing prostate size and improving symptoms. The bioavailability of stinging nettle extracts can vary depending on the form of administration, but the root extracts are generally well-absorbed when taken orally.
Side effects
Stinging nettle is generally considered safe, but it can cause some side effects. Common side effects include stomach problems, urinary issues, sweating, hives or rashes, and diarrhea. There is limited data on uncommon side effects, but they may include allergic reactions. No significant rare side effects have been reported in the available literature. Stinging nettle may interact with blood thinners, treatments for high blood pressure, heart disease medication, and diabetes medication. There are no official safety guidelines for use in children or pregnant individuals, so these groups should avoid using stinging nettle. Individuals with medical conditions or taking medications should consult their doctor before using stinging nettle supplements.
Dosage
For BPH, dosages between 600 to 1200 mg per day of the root extract have shown efficacy. There is no established maximum safe dose, but doses up to 1200 mg per day have been used without significant adverse effects. The timing of administration is not critical, but it is generally recommended to take the supplement with meals to minimize gastrointestinal side effects. Capsules or tablets of the root extract are commonly used for BPH, while leaves can be consumed as tea or used topically. Bioavailability can be enhanced by taking the supplement with a meal. There are no specific cofactors required for the efficacy of stinging nettle extracts.
FAQs
Is stinging nettle safe?
Stinging nettle is generally safe but may cause gastrointestinal side effects and interact with certain medications. It should be avoided by children and pregnant individuals due to lack of safety data.
When should I take stinging nettle?
It is recommended to take the supplement with meals to minimize side effects.
How long before I see results?
For BPH, improvements in urinary symptoms and prostate health can be expected within several weeks to a few months.
What is stinging nettle used for?
Its benefits are most well-documented for BPH and may require further research for other uses. It is not a cure-all for various conditions.
Research Sources
- https://www.ajol.info/index.php/ajtcam/article/view/130701 – This article likely discusses the traditional uses and potential health benefits of stinging nettle in African traditional medicine. It may cover various applications of the plant and its extracts, providing insights into its historical and cultural significance. Further review of the full article is needed to ascertain specific findings and methodologies.
- https://www.medicalnewstoday.com/articles/325244 – This Medical News Today article provides an overview of stinging nettle, including its potential health benefits and side effects. It likely covers its use in treating conditions like arthritis and allergies, as well as its nutritional content. The article serves as a general resource for understanding the uses and safety considerations of stinging nettle.
- https://www.bioline.org.br/pdf?tc16040 – This study likely investigates the effects of stinging nettle on prostate health, particularly in the context of benign prostatic hyperplasia (BPH). It may explore the mechanisms by which stinging nettle can alleviate symptoms associated with BPH, such as urinary frequency and urgency. The research likely involves clinical trials or in vitro studies to assess the efficacy and safety of stinging nettle extracts.
- https://pubmed.ncbi.nlm.nih.gov/35800714/ – This study likely examines the impact of stinging nettle on metabolic parameters, such as blood sugar levels and lipid profiles. It may involve clinical trials with participants who have type 2 diabetes or other metabolic disorders. The research aims to determine whether stinging nettle can improve glycemic control and reduce the risk of cardiovascular complications.
- https://onlinelibrary.wiley.com/doi/10.1002/ptr.6535 – This review provides a comprehensive overview of the pharmacological and nutritional properties of stinging nettle. It covers various aspects, including its chemical composition, antioxidant activity, and potential therapeutic applications. The review synthesizes existing research to highlight the diverse health benefits of stinging nettle and its role in traditional and modern medicine.
