Stoneroot Root Extract
Also known as: Collinsonia canadensis, Stone root, Stoneroot, Richweed, Hardhack, Knob root, Horseweed, Knobweed
Overview
Stoneroot, scientifically known as *Collinsonia canadensis*, is a perennial herb native to North America. The root of the plant is primarily used for medicinal purposes. Traditionally, it has been used for urinary tract issues, including kidney stones, bladder pain, and inflammation, as well as for gastrointestinal complaints and as a diuretic. The herb contains tannins, saponins, and volatile oils, contributing to its astringent and mild diuretic properties. However, it's important to note that the research maturity level for stoneroot is low to moderate, with most evidence being traditional or preclinical. High-quality clinical trials are lacking, and no systematic reviews or meta-analyses specific to stoneroot root extract were identified in major databases. Therefore, the available evidence is primarily based on traditional use, case reports, or preclinical studies.
Benefits
Currently, there is a lack of high-quality randomized controlled trials (RCTs) or meta-analyses demonstrating significant, quantified benefits for stoneroot root extract in any specific clinical indication. Traditional use suggests potential for mild diuresis and urinary tract support. However, clinical efficacy remains unproven. There are no substantiated secondary effects supported by peer-reviewed, controlled studies, and no population-specific benefits have been definitively established. Due to the absence of robust clinical data, effect sizes and clinical significance cannot be accurately determined. The time course of any potential benefits is also not established.
How it works
The proposed mechanisms of action for stoneroot include mild diuretic effects and astringent action on mucous membranes, potentially attributed to its tannin and saponin content. It primarily interacts with the urinary and gastrointestinal systems. However, the specific molecular targets and detailed biological pathways are not well characterized. There is also a lack of pharmacokinetic data available, meaning that information on absorption and bioavailability is currently unavailable.
Side effects
Stoneroot is generally considered safe in typical doses, but safety data are limited. Common side effects have not been reported in clinical studies. Uncommon side effects, potentially affecting 1-5% of users, may include mild gastrointestinal upset, dizziness, nausea, painful urination, and stomach irritation, particularly with larger doses. Rare side effects have not been reported. A moderate drug interaction exists with lithium, as stoneroot may decrease lithium excretion, increasing the risk of toxicity. It may also interact with diuretic drugs, potentially increasing the risk of potassium depletion. Due to insufficient safety data, stoneroot is contraindicated during pregnancy and breastfeeding. It should be avoided in individuals with kidney disease or electrolyte imbalances.
Dosage
Due to the limited clinical evidence, a minimum effective dose, optimal dosage ranges, and maximum safe dose for stoneroot have not been established. Traditional use suggests a dosage of 1–2 g of dried root or an equivalent extract daily, but this is not supported by clinical evidence. There are no specific timing recommendations. Stoneroot is available in various forms, including dried root, tincture, or standardized extract (if available). Absorption factors have not been studied, and no required cofactors have been identified.
FAQs
Is stoneroot effective for kidney stones or urinary tract issues?
No robust evidence supports the efficacy of stoneroot for kidney stones or urinary tract issues. Its use should be approached with caution, especially in individuals taking diuretics or lithium.
Is stoneroot safe to use?
Stoneroot is generally considered safe in typical doses, but it should be avoided during pregnancy and breastfeeding. Monitor for potential side effects, especially if used in conjunction with diuretics or lithium.
When and how should I take stoneroot?
There are no specific timing recommendations for stoneroot administration. Traditional use suggests daily administration. However, it is important to consult with a healthcare professional before starting any new supplement.
What results can I expect from taking stoneroot?
No clinically significant benefits have been demonstrated in peer-reviewed studies. Claims of its effectiveness for specific conditions are largely based on traditional use and have not been scientifically validated.
Is stoneroot a proven treatment for kidney stones or urinary tract infections?
No, stoneroot is not a proven treatment for kidney stones or urinary tract infections. The available evidence is limited, and its use should not replace conventional medical treatments.
Research Sources
- https://www.webmd.com/vitamins/ai/ingredientmono-89/stone-root – WebMD provides general information on stone root, including its uses, potential side effects, and interactions. It notes that stone root is used for urinary tract problems and digestive issues, but there is limited scientific evidence to support these uses. The resource also highlights potential interactions with medications like lithium and diuretics and advises caution during pregnancy and breastfeeding.
- https://www.rxlist.com/supplements/stone_root.htm – RxList offers information on stone root, including its uses, side effects, and interactions. It mentions that stone root has been traditionally used for conditions like urinary tract infections and hemorrhoids, but there is a lack of scientific evidence to support these uses. The resource also warns about potential interactions with certain medications and advises caution in specific populations.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10056569/ – This is a relevant article about herbal medicine usage in urology. It does not specifically mention stoneroot, but it provides context about the use of herbal remedies for urological conditions, highlighting the need for more rigorous research to validate their efficacy and safety. The article underscores the importance of evidence-based approaches in urological care.
- https://pubmed.ncbi.nlm.nih.gov/25449204/ – This study investigates the in vitro effects of several herbal extracts, including Collinsonia canadensis, on prostate cancer cells. While not a clinical trial, it provides preliminary evidence of potential anti-cancer activity, warranting further investigation. The research suggests that Collinsonia canadensis may have compounds that could inhibit the growth of prostate cancer cells in a laboratory setting.
- https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0085008 – This study examines the chemical composition and antimicrobial activity of various plant extracts. While Collinsonia canadensis is not specifically mentioned, the research provides a broader context for understanding the potential antimicrobial properties of plant-based compounds. The study highlights the importance of identifying and characterizing bioactive compounds in plants for potential therapeutic applications.
