Sweet Basil Leaf Extract
Also known as: Sweet Basil, Basil, *Ocimum basilicum* L.
Overview
Sweet Basil Leaf Extract is derived from the leaves of *Ocimum basilicum*, a herb widely cultivated for its aromatic and medicinal properties. Traditionally employed in culinary applications, it has garnered attention for its potential health benefits, including antioxidant, antidiabetic, and anticancer effects. The extract is rich in bioactive compounds such as polyphenols, phenolic acids, and flavonoids, which are responsible for its health-promoting properties. Current research on Sweet Basil Leaf Extract is emerging, with studies primarily focusing on its antidiabetic and anticancer effects, although most evidence is derived from animal models and in vitro experiments rather than robust human clinical trials.
Benefits
The primary evidence-based benefits of Sweet Basil Leaf Extract include: 1) Antidiabetic Effects - A systematic review showed significant lowering of blood glucose levels in diabetic animals (mean difference: -265.59 mg/dL at 100 mg/kg concentration, p < 0.00001). 2) Antioxidant Effects - Enhances antioxidant enzyme activity and reduces lipid peroxidation. 3) Anticancer Properties - Inhibits tumor incidence in animal studies. Secondary effects like antimicrobial and neuroprotective benefits exist but are less researched. The extract shows potential particularly for individuals with diabetes or seeking antioxidant effects, highlighting the need for more human studies to verify these benefits.
How it works
Sweet Basil Leaf Extract primarily exerts its antidiabetic effect by inhibiting enzymes like α-amylase and α-glucosidase, thereby reducing carbohydrate metabolism and glucose absorption. Its antioxidant and anticancer activities are partly attributed to enhancing Phase II enzyme activity, leading to increased glutathione levels and decreased lipid peroxidation. The extract interacts with systems such as the pancreas, liver, and gut, influencing carbohydrate metabolism and detoxification processes. While the detailed bioavailability remains underexplored, extraction methods likely impact its absorption.
Side effects
Sweet Basil Leaf Extract is generally considered safe, with minimal reports of hepatotoxicity in animal studies. Common side effects (>5%) are not well-documented, though gastrointestinal upset may occur. Less common side effects (1-5%) may include allergic reactions or interaction with medications, while rare side effects (<1%) have not been reported. Potential drug interactions include those with diabetes medications due to blood glucose-lowering effects. Pregnant and breastfeeding women should avoid it due to insufficient safety data. Special considerations are warranted for individuals with allergies or those taking other medications.
Dosage
No definitive human dosage recommendations exist for Sweet Basil Leaf Extract. In animal studies, a dose of 100 mg/kg was effective; however, optimal dosages for human use remain unclear and require further investigation. There is no established maximum safe dose, and timing considerations for administration are not specified. The efficacy of various extracts may differ based on extraction methods, and individual absorption may vary considerably. No specific co-factors have been identified to enhance its efficacy.
FAQs
Is Sweet Basil Leaf Extract safe for everyone?
Generally considered safe, but caution is advised for pregnant or breastfeeding women, and those taking medications.
Can it replace diabetes medications?
While it may lower blood glucose, it should not be used as a substitute for prescribed diabetes treatments.
What are the expected effects?
Potential effects include lowered blood glucose levels and antioxidant benefits, but individual results may vary.
Are there any known drug interactions?
Yes, it may interact with diabetes medications; consult a healthcare provider for guidance.
How should it be administered?
The method of administration varies; consult a healthcare professional for personalized advice.
Research Sources
- https://www.ajol.info/index.php/tjnpr/article/download/271398/256187/639014 – This systematic review and meta-analysis highlights the significant antidiabetic impact of basil leaf extract in animal models. Studies demonstrated a mean reduction of blood glucose at a specific concentration, though there were limitations related to bias and study heterogeneity.
- https://pubmed.ncbi.nlm.nih.gov/15070164/ – The study indicates basil leaf extract has anticarcinogenic properties and can inhibit tumor growth in animal models. However, the findings necessitate further exploration in human subjects.
- https://www.mdpi.com/2304-8158/11/20/3212 – This research paper investigates the bioactive compounds in basil leaves, detailing their antioxidant properties. Although it provides essential insights into the chemical composition, the direct health benefits require more extensive human-centered studies.
- https://pubmed.ncbi.nlm.nih.gov/38140476/ – This study examines the antioxidant effects of basil leaf extract, reinforcing the potential health benefits associated with its consumption, particularly focusing on its ability to combat oxidative stress.
- https://tjnpr.org/index.php/home/article/view/3531 – The review discusses the various effects of basil leaf extract, consolidating the data on its therapeutic potentials while delineating limitations within animal model research.
Supplements Containing Sweet Basil Leaf Extract
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