Tian San Qi Root Extract
Also known as: Tian San Qi, Notoginseng, Panax notoginseng
Overview
Panax notoginseng, known as Tian San Qi in traditional Chinese medicine, is a perennial herbaceous plant native to China. The root of this plant is predominantly used in herbal supplements due to its rich content of saponins, which are thought to provide various health benefits. Traditionally, it has been used for cardiovascular health, stroke recovery, and as an anti-inflammatory agent. Key characteristics include its hemostatic, anti-inflammatory, and antioxidant properties. The existing body of research indicates moderate support for its use, especially concerning cardiovascular diseases and stroke recovery, though evidence quality varies due to differing study designs and reporting standards.
Benefits
Panax notoginseng demonstrates several evidence-backed benefits. Research has shown its saponins (PNS) significantly improve outcomes in intracerebral hemorrhage (ICH) patients, evidenced by reduced mortality rates and enhanced neurological function. Anti-inflammatory and antioxidant benefits may also contribute positively to its therapeutic effects, primarily observed among individuals with cardiovascular conditions or stroke. The effectiveness rate in ICH patients receiving PNS treatment was notably higher compared to standard therapies, with benefits typically manifesting within weeks of starting treatment. However, the overall quality of available evidence varies, highlighting the need for further high-quality trials.
How it works
The mechanism of action of Panax notoginseng involves multiple biological pathways, including promoting hemostasis and exhibiting anti-coagulation and anti-thromboembolism effects. It also facilitates cerebral vasodilation and modulates anti-inflammatory pathways, supporting cardiovascular and neurological health. While exact molecular targets remain partly undefined, PNS likely influences various signaling pathways associated with inflammation and vascular function.
Side effects
Panax notoginseng is generally considered safe, with few reported adverse effects. The most commonly noted side effect is skin rash, which is rare. Data on uncommon or rare side effects is limited. Caution is advisable for individuals with bleeding disorders or those taking anticoagulant medications due to potential drug interactions. There is minimal information regarding its use in pregnant or breastfeeding populations, indicating a need for careful consideration in these groups. Overall safety is favorable, but thorough consultations with healthcare providers are essential for at-risk populations.
Dosage
Dosing guidelines for Panax notoginseng are not firmly established, particularly since clinical use often involves injections rather than standardized oral dosages. Although the optimal dosage for injections is often prescribed in studies, oral intake lacks consensus. Key administration is recommended shortly after stroke events to maximize benefits, and while specific maximum safe doses remain undefined, clinical oversight is necessary to determine individual needs and adjustments. Safety thresholds and absorption variables are less documented for oral forms.
FAQs
Is it safe to use Panax notoginseng with other medications?
Generally safe, but caution is advised due to potential interactions with anticoagulants. Always consult a healthcare provider.
How is Panax notoginseng administered?
Typically, it is administered via injection in clinical settings, particularly for acute conditions such as strokes.
What results can I expect from taking Panax notoginseng?
Users may experience improved recovery outcomes in stroke or enhanced cardiovascular health. Note that it complements, not substitutes, traditional treatment.
Is Panax notoginseng suitable for pregnant or breastfeeding women?
There is limited data on its safety in pregnant or breastfeeding women; consult a healthcare provider before use.
How long does it take to see benefits?
Benefits are often observed within weeks of treatment initiation, particularly in stroke recovery contexts.
Research Sources
- https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2014.00274/full – This meta-analysis of randomized controlled trials (RCTs) included 984 patients with intracerebral hemorrhage treated with Panax notoginseng. It demonstrated significant improvements in effectiveness rates, neurological deficit scores, and mortality against standard treatments, despite variability in trial quality and design.
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.1015048/full – A systematic review analyzing the potential benefits of Panax notoginseng, indicating that its application may enhance exercise endurance through anti-inflammatory and antioxidant properties, although the evidence for this is less robust compared to its cardiovascular benefits.
- https://www.mdpi.com/2072-6643/14/6/1185 – The research focuses on the use of Panax notoginseng combined with aspirin for cardiovascular health, demonstrating improved reduction in platelet aggregation compared to aspirin alone among various studied populations.
Supplements Containing Tian San Qi Root Extract
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