Get Your Personalized Supplement StackSupplement Stack Quiz

Veal Bone Pmg Extract

Also known as: Veal Bone PMG Extract, Protomorphogen Extract from Veal Bone, PMG (Protomorphogen) Extract

Overview

Veal Bone PMG Extract is a proprietary supplement ingredient derived from veal bone tissue. It contains a blend of nucleotides, peptides, and other molecular components, collectively known as Protomorphogens (PMG). Marketed primarily to support bone health, joint function, and connective tissue repair, it is often found in supplements targeting osteoarthritis and musculoskeletal support. The extract is hypothesized to influence cellular repair mechanisms through its bioactive peptides and nucleotides. While it is derived from a whole food source, direct clinical research on Veal Bone PMG Extract is limited, with support mainly from proprietary formulations and anecdotal evidence. It is available in tablet form and typically recommended to be taken on an empty stomach. Further research is needed to validate its efficacy and safety.

Benefits

Currently, there is a lack of robust randomized controlled trials (RCTs) that quantify the clinical benefits of Veal Bone PMG Extract. Some evidence supports the role of dietary protein and bone-derived nutrients in maintaining lean mass and bone health, particularly in older adults, but this evidence does not specifically isolate the effects of Veal Bone PMG Extract. While potentially beneficial for older adults or individuals with osteoarthritis, this is not substantiated by direct evidence from RCTs. Therefore, the effect sizes and clinical significance of Veal Bone PMG Extract remain unestablished due to the absence of rigorous trials.

How it works

Veal Bone PMG Extract contains nucleotides and peptides that are proposed to act as signaling molecules, supporting cellular repair and regeneration, particularly in bone and connective tissue. It is thought to interact with the musculoskeletal and immune systems by providing molecular building blocks and signaling factors. While the extract's specific molecular targets are not clearly identified in independent studies, it is believed that the peptides and nucleotides are absorbed and contribute to tissue repair processes.

Side effects

Veal Bone PMG Extract is generally considered safe when used as directed in supplement form, although large-scale safety trials are lacking. Common or uncommon side effects have not been reported in the available literature. Due to limited research, rare side effects are also unknown. No drug interactions have been documented. However, caution is advised for pregnant or nursing women and individuals with impaired liver function, based on product warnings. It is generally not intended for long-term use, and consultation with a healthcare provider is recommended for individuals with pre-existing health conditions or those who are pregnant or nursing.

Dosage

The minimum effective and maximum safe doses of Veal Bone PMG Extract have not been established through clinical trials. Commonly, it is marketed as one tablet taken three times daily on an empty stomach, as seen with products like Ostrophin PMG®. This recommendation is based on product formulations rather than clinical evidence. Taking it on an empty stomach is suggested to potentially enhance absorption, although specific absorption factors are not well-documented. Due to the lack of comprehensive research, it is important to adhere to product-specific guidelines and consult with a healthcare professional.

FAQs

Is Veal Bone PMG Extract effective for osteoarthritis?

There is no direct high-quality clinical evidence supporting its efficacy specifically for osteoarthritis. More research is needed to determine its potential benefits.

Is it safe for long-term use?

It is not recommended for long-term use without medical supervision due to the lack of comprehensive safety data.

When should it be taken?

It is typically recommended to be taken on an empty stomach, three times daily, to potentially enhance absorption.

Is it the same as bone broth?

No, it is a concentrated extract with specific nucleotides and peptides, unlike the broader nutrient profile of bone broth.

What results can be expected?

No clear clinical outcomes are established; anecdotal reports suggest support for joint and bone health, but rigorous evidence is lacking.

Research Sources

https://www.danielsfamilychiro.com/storage/app/media/Patient_Information-_Supplementation/Cataplex_C.pdf – This source is a product information sheet for Cataplex C, which contains Veal Bone PMG extract. It does not provide clinical data but lists the ingredients of the product. The information is of low quality due to the absence of controls or outcomes.
https://pubmed.ncbi.nlm.nih.gov/29018060/ – This systematic review on dietary supplements for osteoarthritis did not identify Veal Bone PMG as a studied ingredient. Therefore, it provides no direct evidence regarding the efficacy of Veal Bone PMG for osteoarthritis. While the review itself is of high quality, it offers no data specific to Veal Bone PMG.
https://www.standardprocess.com/products/ostrophin-pmg – This is a product description for Ostrophin PMG, which contains Veal Bone PMG extract. It provides recommended dosing information but lacks clinical trial data to support its efficacy. The quality of evidence is low due to the absence of clinical trial data.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4892287/ – This meta-analysis of 20 RCTs examined the effects of dietary protein intake on body composition in adults over 50. It found that higher protein intake helps retain lean mass during weight loss. While the study is of high quality, its relevance to Veal Bone PMG extract is indirect, as it does not specifically investigate the extract's effects.
https://pubs.acs.org/doi/10.1021/acsomega.2c01379 – This experimental study focuses on the biological activity of bone-derived hydroxyapatite from bone wastes. It demonstrates that bone-derived hydroxyapatite has biological activity. However, it is not a clinical study and focuses on material properties, making its clinical relevance limited.