Veldt Grape Extract
Also known as: Veldt grape, Hadjod, Asthisamharaka, Cissus quadrangularis
Overview
*Cissus quadrangularis* is a perennial plant native to Africa and Asia, recognized in Ayurvedic and Unani medicine for treating bone and joint disorders. The extract is primarily used for its osteogenic, anti-osteoarthritic, and weight management properties. Rich in phenolics and flavonoids, the plant exhibits therapeutic effects that have been evaluated through multiple clinical trials and reviews, signifying its moderate to high level of research maturity. Its primary applications include supporting bone health, managing osteoarthritis, aiding in weight management, and potentially alleviating hemorrhoidal symptoms. While evidence is generally robust, particularly for bone health and weight management, high-quality studies with larger sample sizes remain necessary for definitive conclusions regarding some benefits.
Benefits
*Cissus quadrangularis* has several evidence-based benefits: 1) **Bone Health and Osteoarthritis** - The stem extract has been shown to significantly improve joint health in both animal and human studies, outperforming conventional treatments like naproxen in some models. 2) **Weight Management** - In combination products, it has demonstrated a mean reduction in body weight of approximately -5.19 kg, beneficial for obese individuals. 3) **Hemorrhoids** - Although some studies suggest potential symptom relief, evidence remains weak. 4) **Anti-hyperglycemic Effects** - The extract may inhibit gluconeogenesis and lipogenesis, showing promise for type 2 diabetics. The strongest evidence supports benefits for postmenopausal women and individuals with osteoarthritis, demonstrating that notable improvements can often be observed within several weeks of supplementation.
How it works
The active compounds in *Cissus quadrangularis* modulate biological pathways linked to bone metabolism, inflammation, and lipid metabolism. It enhances bone formation while reducing resorption, thereby promoting bone density. Additionally, it interacts with metabolic pathways to improve glucose and lipid profiles, potentially offering protective effects against metabolic disorders and aiding in joint health through the modulation of key synovial and cartilage markers.
Side effects
Generally, *Cissus quadrangularis* is considered safe with no serious adverse effects reported in clinical literature. No common side effects occur at frequencies greater than 5%, and uncommon effects are not documented. Rare but significant risks have not been identified. Caution should be exercised for pregnant or breastfeeding women due to insufficient safety data in these groups, and individuals on medications for bone or metabolic conditions should consult healthcare providers before use. Overall, its antioxidant properties may offer a favorable safety profile, but further evaluation on drug interactions is warranted.
Dosage
The effective dosage of *Cissus quadrangularis* varies, with studies recommending 500-1000 mg daily for bone health and osteoarthritis. For weight management, daily doses totaling around 1-2 grams in combination products are effective. Although upper limits have not been firmly established, doses up to 2 grams per day have been used safely. Taking the extract consistently daily is advisable for optimal results, and it may be more effective in the form of the stem extract as opposed to roots. Bioavailability could potentially be enhanced when taken with meals.
FAQs
Is *Cissus quadrangularis* safe?
Yes, *Cissus quadrangularis* is generally safe, but it's important to consult a healthcare provider if you have health conditions or are taking medications.
When should I take *Cissus quadrangularis*?
It can be taken at any time of day; consistency in daily intake is crucial for achieving optimal benefits.
How long does it take to see results?
Most individuals may see improvements in bone health and weight management within several weeks to months of consistent supplementation.
Can *Cissus quadrangularis* help with weight loss?
It can play a role in weight management, but it is not a quick fix and should be part of a broader health regimen.
Research Sources
- https://pubs.rsc.org/en/content/articlelanding/2020/fo/d0fo00992j – This systematic review and meta-analysis evaluates the efficacy and safety of *Cissus quadrangularis*, demonstrating significant benefits in bone health and weight management with no serious adverse effects reported.
- https://pubmed.ncbi.nlm.nih.gov/39437887/ – An in vivo study on an osteoarthritis model shows that *Cissus quadrangularis* stem extract significantly improves joint health compared to standard treatments, highlighting the potential for arthritis management.
- https://www.semanticscholar.org/paper/Efficacy-and-Safety-of-Cissus-quadrangularis-L.-in-Sawangjit-Puttarak/1cbd8643f6bef55572622106d41d116b26343041 – This study discusses the possible benefits of *Cissus quadrangularis* on bone health and highlights the need for more extensive trials to confirm its efficacy in treating conditions like hemorrhoids.
- https://pubmed.ncbi.nlm.nih.gov/28165166/ – A clinical pilot study indicates the potential of *Cissus quadrangularis* in relieving symptoms of hemorrhoids, although larger randomized controlled trials are needed for definitive conclusions.
Supplements Containing Veldt Grape Extract
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