Veldt Grape Leaf Extract
Also known as: Veldt grape, Adamant creeper, Asthisamharaka, *Cissus quadrangularis*
Overview
*Cissus quadrangularis* is a perennial plant native to Africa and Asia, commonly used in traditional Ayurvedic medicine. Known for its various health benefits, it is particularly recognized for its roles in promoting bone health, aiding in wound healing, and possessing anti-inflammatory properties. The plant is enriched with flavonoids, triterpenes, and other bioactive compounds that may contribute to these effects. Research on this supplement is moderate, mainly comprised of animal studies, with limited human trials available to support its efficacy. Consequently, while there is some evidence of its potential benefits, more comprehensive clinical research is needed to validate these findings and understand its full range of effects.
Benefits
The primary benefits associated with *Cissus quadrangularis* include enhanced bone health and anti-inflammatory effects, specifically promoting bone density and reducing inflammation in animal studies. Secondary benefits may include antioxidant and anti-diabetic properties, although specific quantified outcomes in human studies are lacking. Research on its effectiveness in specific populations, such as athletes or the elderly, is still emerging. The general clinical significance of these benefits remains uncertain due to the minimal high-quality human evidence available.
How it works
*Cissus quadrangularis* may exert its effects through interaction with estrogen receptors, influencing bone metabolism and potentially benefiting skeletal health. Its flavonoid constituents, such as quercetin and daidzein, are thought to exhibit antioxidant properties, supporting the immune system and reducing oxidative stress. However, the specific biological pathways and mechanisms by which it operates are not fully understood, particularly regarding human absorption and bioavailability.
Side effects
The safety profile of *Cissus quadrangularis* appears to be favorable based on available animal studies, but comprehensive human data is lacking. Common side effects are not well-documented, while rare adverse effects, such as thrombocytopenia, have been reported in isolated cases. There may be potential interactions with immunosuppressive drugs, necessitating caution for individuals on such medications. Immunocompromised individuals are also advised to be cautious. Additionally, pregnant or breastfeeding women should consult healthcare providers due to insufficient safety data in these populations. Overall, safety and efficacy require further assessment in well-designed clinical trials.
Dosage
No established effective dosage for humans exists as *Cissus quadrangularis* is often used based on traditional medicine practices. Optimal dosages remain undefined, and while animal studies suggest that high doses could be safe, the specific dosing for humans has yet to be determined. Recommendations for timing or absorption aspects are currently not specified, and an absence of solid evidence on upper limits means caution should be exercised until more robust data becomes available. Due to the lack of standardized forms, it is commonly used as an extract, with the necessary cofactors for effective absorption still unidentified.
FAQs
Is *Cissus quadrangularis* safe to use?
Generally considered safe based on animal studies, but limited human research necessitates caution, especially for those on medications.
What benefits can I expect from taking this supplement?
Potential benefits include improved bone health and anti-inflammatory effects, though more research is needed for conclusive evidence.
How should I take *Cissus quadrangularis*?
There are no specific guidelines for dosage; consult a healthcare provider for personal recommendations.
Can I use it while pregnant or breastfeeding?
Consult a healthcare provider before use due to limited safety data in these populations.
Does it interact with any medications?
It may interact with immunosuppressive drugs; caution is advised for individuals taking such medications.
Research Sources
- https://pubs.rsc.org/en/content/articlelanding/2020/fo/d0fo00992j – This article discusses the bioactive compounds in *Cissus quadrangularis* and their potential therapeutic effects based on phytochemical analysis.
- https://dspace.nuft.edu.ua/server/api/core/bitstreams/e4902ec5-1f2b-48c0-85f0-1345f8055553/content – The study outlines the application of *Cissus quadrangularis* in traditional medicine and its pharmacological properties, emphasizing its effectiveness in osteoarthritis.
- http://www.ukaazpublications.com/publications/wp-content/uploads/2025/01/32-Sury-Pratap-Singh-327-340.pdf – This research provides insights into the potential health benefits of *Cissus quadrangularis* and its role in enhancing bone density in pre-clinical models.
- https://pubmed.ncbi.nlm.nih.gov/32812575/ – The article reviews the effects of *Cissus quadrangularis* on inflammation and bone health, highlighting the need for further human studies to corroborate animal findings.
- https://www.researchgate.net/publication/385166905_Veld_Grape_An_Unattended_Medicinal_Plant – This publication elaborates on the ethnopharmacological importance of *Cissus quadrangularis* and calls for systematic reviews to evaluate its medicinal efficacy.
Supplements Containing Veldt Grape Leaf Extract
Recommended Articles
Herbal Boosters & COVID-19 Antivirals: Safe Mix?
Herbal supplements may interact with COVID-19 antivirals, requiring careful consideration and further research.
Top Immune Support Ingredients: What Works?
Vitamin D, zinc, and echinacea are key ingredients in immune support supplements, backed by scientific evidence.
Top Anti-Inflammatory Supplement Ingredients
Curcumin, omega-3 fatty acids, CBD, and Vitamin D are proven to effectively reduce chronic inflammation.
Best Supplements for Cortisol Reduction: A Scientific Guide
Adaptogens like Ashwagandha and Rhodiola, along with Phosphatidylserine, are effective in reducing cortisol levels, supported by scientific studies.