Wasabi Root Extract
Also known as: Wasabi, Wasabi root extract, Japanese horseradish, Wasabia japonica, 6-methylsulfinyl hexyl isothiocyanate, 6-MSITC, Eutrema japonicum
Overview
Wasabi root extract is derived from the rhizome of *Eutrema japonicum*, a plant native to Japan. It is characterized by its pungent flavor and potential health benefits, primarily attributed to bioactive compounds like 6-methylsulfinyl hexyl isothiocyanate (6-MSITC). Traditionally used in Japanese cuisine, wasabi is now being studied for its anti-inflammatory, antioxidant, and potential anti-cancer properties. The extract is available in various forms, including powders, capsules, and pastes. Research on wasabi is ongoing, with studies ranging from in vitro and animal models to human clinical trials. While the quality of evidence varies, emerging research suggests promising effects, particularly concerning cognitive function and anti-tumor activity. However, more extensive, high-quality clinical trials are needed to fully validate these benefits.
Benefits
Wasabi root extract offers several potential health benefits. A double-blinded RCT demonstrated that 6-MSITC supplementation improved working and episodic memory in older adults. In vitro and in vivo studies suggest that 6-MSITC has anti-tumor effects against certain cancer cells, including endometrial carcinoma, and enhances natural killer (NK) cell activity. Additionally, wasabi extract exhibits anti-inflammatory and antioxidant properties, potentially reducing the risk of chronic diseases. Animal studies indicate potential benefits for gut health and blood pressure regulation. Cognitive benefits appear significant for older adults, while anti-inflammatory effects may benefit the general population. Improvements in cognitive function have been observed after 12 weeks of supplementation with 6-MSITC.
How it works
Wasabi's bioactive compounds, such as 6-MSITC, exert their effects through multiple biological pathways. Primarily, they act as anti-inflammatory and antioxidant agents, influencing cellular health and immune function. 6-MSITC has been shown to suppress cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), thereby reducing inflammation. The compounds interact with the nervous system, potentially contributing to cognitive benefits, and the immune system, enhancing NK cell activity. Animal studies suggest potential effects on the cardiovascular system through blood pressure regulation. While human bioavailability data is limited, animal studies indicate that oral administration can be effective.
Side effects
Wasabi root extract is generally considered safe when consumed in typical culinary amounts. However, higher doses or prolonged use may lead to adverse effects. Common side effects include gastrointestinal discomfort, such as heartburn or stomach upset, which may occur in more than 5% of individuals. Uncommon side effects, affecting 1-5% of users, may include allergic reactions or skin irritation. Rare side effects are not well-documented. Wasabi may interact with blood thinners or diabetes medications due to its antiplatelet and glucose-modulating effects. Individuals with severe allergies to cruciferous vegetables should avoid wasabi. Pregnant or breastfeeding women should consult healthcare providers before using wasabi supplements. It is important to monitor for any adverse reactions and discontinue use if significant side effects occur.
Dosage
The minimum effective dose of 6-MSITC for cognitive benefits is approximately 0.8 mg per day, as used in clinical studies. However, optimal dosage ranges for various health benefits are not well established and require further research. There is no established maximum safe dose, but high doses should be approached with caution. Consistent daily intake may be beneficial, but specific timing recommendations are lacking. Wasabi is commonly available in capsules or extracts; ensure the product contains bioactive compounds like 6-MSITC. Bioavailability may be influenced by food intake and digestive health. No specific cofactors are required for wasabi's effects.
FAQs
Is wasabi root extract safe?
Generally safe in culinary amounts, but high doses may cause gastrointestinal upset. Not a substitute for medical treatments.
How should I take wasabi root extract?
Consistent daily intake is recommended. Capsules or extracts are common forms. Ensure the product contains bioactive compounds.
What are the expected benefits of wasabi?
Cognitive improvements have been documented, but other effects require more research. Benefits may vary among individuals.
Can wasabi replace my medications?
No, wasabi is not a substitute for medical treatment. Consult a healthcare provider for medical conditions.
Is wasabi the same as horseradish?
No, wasabi is often confused with horseradish; genuine wasabi has distinct health benefits and chemical composition.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10648564/ – This RCT with 72 participants over 12 weeks found that 6-MSITC supplementation improved working and episodic memory in older adults. The study highlights the potential cognitive benefits of wasabi compounds, although the sample size was relatively small and the improvements were specific to certain cognitive domains.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC9871149/ – This in vitro and in vivo study demonstrated that 6-MITC exhibited anti-tumor effects against endometrial carcinoma cells and enhanced NK cell activity. While promising, these findings are based on animal and cell studies, necessitating further human trials to confirm the anti-cancer potential of wasabi compounds.
- https://www.mdpi.com/2304-8158/11/21/3435 – This research explores the anti-inflammatory properties of Wasabi and its components, particularly focusing on the suppression of inflammatory markers. It provides insights into the molecular mechanisms through which Wasabi may exert its health benefits, supporting its traditional use as a medicinal plant.
- https://www.frontiersin.org/articles/10.3389/fpls.2022.1043378/full – This study investigates the potential of Wasabi to modulate the gut microbiome and its impact on hypertension in rats. The findings suggest that Wasabi extract can alter the gut microbiome composition, leading to a reduction in blood pressure, indicating a potential therapeutic role in managing hypertension, although human studies are needed to validate these results.
- https://betterme.world/articles/wasabi-health-benefits/ – This article provides a general overview of the health benefits of wasabi, including its antioxidant and anti-inflammatory properties. It highlights the potential role of wasabi in supporting overall health and well-being, although it is not a peer-reviewed scientific study.
Supplements Containing Wasabi Root Extract
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