Wild Indigo Extract
Also known as: Wild Indigo, Indigo Plant, Indigofera, Indigo naturalis, Indigofera tinctoria
Overview
Wild Indigo extract is derived from the leaves and other parts of the Indigo plant, historically used in traditional medicine for its anti-inflammatory and antimicrobial properties. Rich in unique bioactive compounds such as tryptanthrin, it has garnered attention for its therapeutic potential, particularly in treating ulcerative colitis. Recent research indicates variable evidence regarding its benefits, especially regarding gastrointestinal health and potential antiviral properties. Though clinical trials have provided positive findings, particularly for inflammatory bowel diseases, prevalent research gaps necessitate more thorough long-term, high-quality investigations to establish definitive efficacy and safety.
Benefits
Wild Indigo extract demonstrates evident benefits primarily for individuals with mild to moderate ulcerative colitis, significantly improving clinical response and remission rates. A systematic review shows that the extract, particularly at doses up to 2 g/day, offers significant treatment effects (81% response rate vs. 13.6% placebo, p < 0.0001). Additionally, in vitro studies suggest potential antiviral properties against SARS-CoV-2, inhibiting binding to the ACE2 receptor, albeit requiring further validation. Some reports indicate improvements in gastrointestinal symptoms, though these findings vary in consistency and require more robust confirmation across diverse populations.
How it works
The therapeutic effects of Wild Indigo extract are primarily attributed to its bioactive compound, tryptanthrin, which exhibits anti-inflammatory properties. These compounds interact with biological pathways to reduce inflammation, especially beneficial in gastrointestinal disorders like ulcerative colitis. The extract also shows potential antiviral activity by disrupting the binding of SARS-CoV-2 spike protein to the ACE2 receptor, suggesting a dual mechanism involving immune modulation and virus inhibition. Overall, it influences key bodily systems, particularly the gastrointestinal and immune systems.
Side effects
Wild Indigo extract is generally considered safe for short-term usage; however, mild adverse effects have been reported, including liver dysfunction, headache, epigastric/abdominal pain, and nausea in more than 5% of users. Uncommon side effects (1-5%) are not well documented, and serious adverse events remain infrequent. Users should take caution when combining this extract with medications affecting liver function or gastrointestinal health. Contraindications exist for those on TNFα inhibitors or immunosuppressive drugs, requiring careful medical supervision. Pregnant or breastfeeding women should consult healthcare professionals, due to limited safety data in these groups.
Dosage
Recommended dosages of Wild Indigo extract for ulcerative colitis typically range from 0.5 g to 2 g daily, with optimal efficacy observed at approximately 1-2 g per day split into multiple doses. Consistent timing, preferably with meals, can help alleviate gastrointestinal discomfort. While the maximum safe dose is not well-defined, clinical trials have utilized doses up to 2 g per day without significant adverse effects. Variability in absorption of the extract may be present depending on the food intake and formulation type, with options including capsules or powder.
FAQs
Is Wild Indigo extract safe?
Generally, Wild Indigo extract is safe for short-term use, though mild to moderate side effects may occur. Long-term safety remains understudied.
How should I take Wild Indigo extract?
It is advisable to take Wild Indigo extract with meals to reduce gastrointestinal side effects.
When can I expect to see results?
Patients with ulcerative colitis may expect clinical improvements within 6-8 weeks of starting treatment.
Is it a cure for ulcerative colitis?
Wild Indigo extract is not a cure but can serve as a complementary treatment alongside standard therapies.
Research Sources
- https://www.mdpi.com/2072-6643/16/7/934 – This systematic review and meta-analysis of RCTs assessed the effectiveness of Indigo naturalis in treating ulcerative colitis, showcasing significant clinical response improvement with 2 g/day dosage.
- https://pubmed.ncbi.nlm.nih.gov/34134667/ – This clinical trial focused on 70 patients with mild to moderate ulcerative colitis, reporting significant differences in clinical response and remission rates when compared to placebo.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC8892618/ – An in vitro study revealing that tryptanthrin from Indigo extract inhibits the binding of SARS-CoV-2 spike protein to ACE2, implying potential antiviral properties requiring further investigation.
- https://www.science.gov/topicpages/c/complementary+treatment+modality.html – This source discusses complementary treatment modalities, illustrating the relevance of herbal supplements, including Wild Indigo, in integrative health approaches.
- https://www.ekosfop.or.kr/archive/view_article?pid=kjfp-29-3-367 – This article provides an overview of the pharmacological effects of various medicinal plants, with a reference to the significance of Wild Indigo in traditional medicinal practices.
Supplements Containing Wild Indigo Extract
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