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Zhu Ling Extract

Also known as: Zhu Ling, Polyporus mushroom extract, Polyporus umbellatus

Overview

Zhu Ling extract is derived from the sclerotium of *Polyporus umbellatus*, a medicinal mushroom species widely used in Traditional Chinese Medicine (TCM). Traditionally, it is employed for its diuretic properties, helping to reduce edema and support kidney function. While it is a recognized ingredient in TCM, research on Zhu Ling extract as a standalone supplement is limited. Most clinical evidence supporting its benefits comes from studies of multi-herb formulas, such as Shen-Ling-Bai-Zhu-San (SLBZS) and Jeoryeong-tang, which are used for a range of conditions including digestive disorders, edema, and urinary issues. The evidence base for Zhu Ling is emerging, but high-quality randomized controlled trials focusing solely on the isolated extract are scarce, indicating that its effects are primarily observed within the context of complex herbal formulations.

Benefits

Zhu Ling-containing formulas have shown potential benefits across several conditions, though the specific contribution of Zhu Ling itself is often unclear due to its inclusion in multi-herb preparations. For ulcerative colitis (UC), formulas like SLBZS have demonstrated some efficacy in reducing symptoms, although clinical heterogeneity and variable dosing in studies limit definitive conclusions. In lung cancer, SLBZS combined with chemotherapy may improve treatment efficacy and reduce side effects, possibly by modulating immune function and tumor-related pathways. Additionally, Chinese herbal medicines, including those with Zhu Ling, have shown some reduction in migraine frequency. Meta-analyses of these formulas indicate modest improvements, such as a reduction of approximately one migraine attack per month, but high heterogeneity across studies and the lack of direct data on isolated Zhu Ling reduce the confidence in attributing these effects solely to Zhu Ling.

How it works

The proposed mechanisms of action for Zhu Ling involve the modulation of immune responses and the induction of diuretic effects. Its bioactive compounds are thought to activate key signaling pathways, such as PI3K-Akt-mTOR, which are involved in cell growth, proliferation, and survival, potentially inhibiting tumor growth promoters. Furthermore, Zhu Ling may contribute to immune system modulation by influencing intestinal flora. While these mechanisms are suggested, the specific details regarding the absorption and bioavailability of isolated Zhu Ling extract in the human body are not yet well characterized in scientific literature.

Side effects

Zhu Ling and its associated multi-herb formulas are generally considered safe based on traditional use and available clinical studies. Systematic reviews have not reported major adverse events. Common side effects are not well documented, suggesting they are minimal if present. Currently, no significant drug interactions or contraindications have been clearly identified for Zhu Ling. However, caution is advised when Zhu Ling-containing formulas are used in conjunction with chemotherapy, as potential herb-drug interactions cannot be entirely ruled out without further research. Overall, the safety profile appears favorable, but more specific data on isolated Zhu Ling extract would be beneficial.

Dosage

Specific dosing guidelines for isolated Zhu Ling extract are not standardized due to the lack of research focusing solely on the single ingredient. In traditional practice and clinical trials, Zhu Ling is typically administered as part of multi-herb formulas, such as Shen-Ling-Bai-Zhu-San (SLBZS) and Jeoryeong-tang. The dosages of these formulas vary widely, and the precise amount of Zhu Ling within them is not always clearly delineated or consistent across studies. Therefore, optimal dosing, timing, and form (e.g., extract concentration) for standalone Zhu Ling extract require further dedicated research to establish safe and effective recommendations. There are no established upper limits or safety thresholds for isolated Zhu Ling.

FAQs

Is Zhu Ling extract effective alone?

Current evidence primarily supports the efficacy of Zhu Ling when used as part of multi-herb formulas, rather than as a standalone supplement. Research on its isolated effects is limited.

Is Zhu Ling extract safe?

Zhu Ling and its formulas are generally considered safe with no major adverse events reported in studies. However, high-quality safety data specifically for isolated Zhu Ling extract are limited.

When can I expect to see results from Zhu Ling?

Based on clinical trials of herbal formulas containing Zhu Ling, benefits typically appear after several weeks of consistent treatment, which is common for many herbal medicines.

Research Sources

https://journals.lww.com/md-journal/fulltext/2018/09210/shen_ling_bai_zhu_san_for_ulcerative_colitis_.36.aspx – This systematic review evaluated the efficacy of Shen-Ling-Bai-Zhu-San (SLBZS), which contains Zhu Ling, for ulcerative colitis. It found some symptom improvement but noted significant heterogeneity among included RCTs and a lack of standardized dosing, limiting definitive conclusions on its effectiveness.
https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.889336/full – This systematic review and meta-analysis assessed Chinese herbal medicines, including Zhu Ling-containing formulas, for migraine. It concluded that these formulas reduced migraine frequency by approximately 1.15 attacks per month, but highlighted high heterogeneity and the inability to distinguish the isolated effect of Zhu Ling.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7886466/ – This systematic review protocol outlines a study to evaluate the efficacy and safety of Shen-Ling-Bai-Zhu-San (SLBZS) combined with chemotherapy for lung cancer. Preliminary data suggest potential mechanisms involving immune modulation and tumor growth inhibition, with full results pending.
https://pubmed.ncbi.nlm.nih.gov/33578558/ – This article, related to the systematic review protocol, further discusses the potential of SLBZS in lung cancer treatment. It suggests that SLBZS may improve treatment efficacy and reduce side effects when combined with chemotherapy, likely through immune-modulating and anti-tumor pathways.