ProveIt Supplements

Independent, evidence-based supplement analysis.

✓ Not Sponsored

✓ No Paid Reviews

✓ Science-Based

Company

  • About Us
  • Our Methodology
  • Contact
  • Blog
  • Authors

Legal

  • Privacy Policy
  • Terms of Service
  • Medical Disclaimer
  • Affiliate Disclosure

Resources

  • All Categories
  • Ingredient Database
  • Browse Supplements
  • FAQ

© 2025 ProveIt Supplements. All rights reserved.

Medical Disclaimer: The information provided is for educational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen.

Prove It
Browse SupplementsBlogAuthorsAboutMethodologyFAQ
Get Your Personalized Supplement StackSupplement Stack Quiz
Menu
HomeBrowse SupplementsBlogAuthorsAboutMethodologyFAQ
SAMe 400 mg

SAMe 400 mg

California Gold Nutrition

#Other
65
Safety70
Efficacy60
Transparency85
Based on Examine, Wikipedia, and 23 other sources

Overview

S-Adenosylmethionine (SAMe) is a compound that plays a role in various biological processes. While it has shown promise for supporting liver health and improving symptoms of depression, the clinical evidence is not robust. This product contains 400mg of SAMe, which is within a range used in some studies, but the effectiveness may vary across individuals and conditions. Further research is needed to fully establish therapeutic efficacy.

The Good

May support liver function and reduce liver enzyme levels

Potential to help manage depressive symptoms based on research

May act as a methyl donor and support antioxidant defense

The Bad

Potential for gastrointestinal side effects like nausea

May interact with certain medications such as antidepressants and L-dopa

Not recommended for individuals with bipolar disorder or manic depression

Is it for you?

Best For: Individuals seeking mood support, liver health, or joint comfort

Skip If: You are pregnant, nursing, bipolar, or taking antidepressant medications without consulting a doctor.

Ingredients Analysis

S-Adenosylmethionine

400 mg

Ademetionine 1;4-Butanedisulfonate

800 mg

How to Use

Take 1 tablet daily, or as directed by a healthcare professional. It is best absorbed on an empty stomach.

Frequency:

Daily

Best Time:

Morning or throughout the day

When:

Between meals or on an empty stomach for best absorption

Who Should Use This

Best For:

Individuals seeking mood support, liver health, or joint comfort

Similar Products

Vetri-Science® Laboratories Healthymouth™ Natural Zeolites for Dogs & Cats Dental Health Supplement by Vetriscience®

Vetri-Science® Laboratories Healthymouth™ Natural Zeolites for Dogs & Cats Dental Health Supplement

Vetriscience®

COLLAGEN PRO Pasture Raised Peptides UNFLAVORED DIETARY SUPPLEMENT by GNARLY®

COLLAGEN PRO Pasture Raised Peptides UNFLAVORED DIETARY SUPPLEMENT

GNARLY®

SAM-e S-Adenosylmethionine 200 mg by PhysioLogics

SAM-e S-Adenosylmethionine 200 mg

PhysioLogics

Muscle memory Creatine Powder supplement by Ora®

Muscle memory Creatine Powder supplement

Ora®

Amazing Formulas MSM (Methylsulfonylmethane) Supplement by Amazing Nutrition

Amazing Formulas MSM (Methylsulfonylmethane) Supplement

Amazing Nutrition

Fiber GDX Dietary Supplement Fiber / Orange Flavor by THE PAUSENUTRITION®

Fiber GDX Dietary Supplement Fiber / Orange Flavor

THE PAUSENUTRITION®

Recommended Articles

Top Immune Support Ingredients: What Works?

Top Immune Support Ingredients: What Works?

Vitamin D, zinc, and echinacea are key ingredients in immune support supplements, backed by scientific evidence.

L-Theanine Dosage for Focus: Avoid Drowsiness

L-Theanine Dosage for Focus: Avoid Drowsiness

200-400mg daily of L-theanine enhances focus without causing drowsiness, with benefits amplified when combined with caffeine.

Best Supplements for Cortisol Reduction: A Scientific Guide

Best Supplements for Cortisol Reduction: A Scientific Guide

Adaptogens like Ashwagandha and Rhodiola, along with Phosphatidylserine, are effective in reducing cortisol levels, supported by scientific studies.

Best Protein Types for Fitness Goals

Best Protein Types for Fitness Goals

Different protein types and sources are optimized for muscle gain, weight management, and overall health, catering to all diets.