ProveIt Supplements

Independent, evidence-based supplement analysis.

✓ Not Sponsored

✓ No Paid Reviews

✓ Science-Based

Company

  • About Us
  • Our Methodology
  • Contact
  • Blog
  • Authors

Legal

  • Privacy Policy
  • Terms of Service
  • Medical Disclaimer
  • Affiliate Disclosure

Resources

  • All Categories
  • Ingredient Database
  • Browse Supplements
  • FAQ

© 2025 ProveIt Supplements. All rights reserved.

Medical Disclaimer: The information provided is for educational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen.

Prove It
Browse SupplementsBlogAuthorsAboutMethodologyFAQ
Get Your Personalized Supplement StackSupplement Stack Quiz
Menu
HomeBrowse SupplementsBlogAuthorsAboutMethodologyFAQ
St. John's Wort Extract 300 mg

St. John's Wort Extract 300 mg

Source Naturals

#Other
58
Safety45
Efficacy70
Transparency80
Based on Examine, Wikipedia, and 23 other sources

Overview

St. John's Wort extract has demonstrated effectiveness in managing mild to moderate depression by influencing neurotransmitter activity. The standardized extract ensures a consistent amount of active hypericins, which are believed to contribute to its therapeutic effects. However, the onset of effects is not immediate, requiring several weeks of consistent use.

The Good

May effectively improve mood and support a positive mental outlook for individuals with mild to moderate depression.

Offers a natural alternative to pharmaceutical antidepressants, with a potential for fewer side effects in some cases.

Standardized extract ensures consistent potency and hypericin content.

The Bad

Significant drug interactions are possible, including with common medications such as oral contraceptives, antidepressants, and anticoagulants.

May increase sensitivity to sunlight, requiring caution and sun protection.

Can cause gastrointestinal upset such as abdominal pain, nausea, and vomiting.

Is it for you?

Best For: Individuals seeking natural mood support, those with mild to moderate depressive symptoms

Skip If: You are taking prescription medications (especially antidepressants, birth control, blood thinners), are pregnant or breastfeeding, or have bipolar disorder.

Ingredients Analysis

Calcium

31 mg

St. John'S Wort

300 mg

Hypericins

0.9 mg

How to Use

Take 1 tablet daily, or as directed by your healthcare professional.

Frequency:

Daily

Best Time:

Morning or Evening

When:

With food

Who Should Use This

Best For:

Individuals seeking natural mood support, those with mild to moderate depressive symptoms

Similar Products

B12 by Jamieson Natural Sources

B12

Jamieson Natural Sources

Honey Roasted Almonds by BLUE DIAMOND

Honey Roasted Almonds

BLUE DIAMOND

fairlife® CORE POWER® High Protein Milk Shake Vanilla Flavored with other natural flavors by fairlife®

fairlife® CORE POWER® High Protein Milk Shake Vanilla Flavored with other natural flavors

fairlife®

ultima REPLENISHER Lemonade Flavored with other natural flavors by ultima REPLENISHER

ultima REPLENISHER Lemonade Flavored with other natural flavors

ultima REPLENISHER

Magnetic Eyeliner & False Eyelashes Kit - Lure by KISS

Magnetic Eyeliner & False Eyelashes Kit - Lure

KISS

OLIGOVANCE by Inovance®

OLIGOVANCE

Inovance®

Recommended Articles

Herbal Boosters & COVID-19 Antivirals: Safe Mix?

Herbal Boosters & COVID-19 Antivirals: Safe Mix?

Herbal supplements may interact with COVID-19 antivirals, requiring careful consideration and further research.

Top Immune Support Ingredients: What Works?

Top Immune Support Ingredients: What Works?

Vitamin D, zinc, and echinacea are key ingredients in immune support supplements, backed by scientific evidence.

Top Anti-Inflammatory Supplement Ingredients

Top Anti-Inflammatory Supplement Ingredients

Curcumin, omega-3 fatty acids, CBD, and Vitamin D are proven to effectively reduce chronic inflammation.

Best Supplements for Cortisol Reduction: A Scientific Guide

Best Supplements for Cortisol Reduction: A Scientific Guide

Adaptogens like Ashwagandha and Rhodiola, along with Phosphatidylserine, are effective in reducing cortisol levels, supported by scientific studies.