Angelica Gigas Root Extract
Also known as: Korean Angelica, Giant Angelica, Angelica gigas Nakai, Angelica gigas
Overview
*Angelica gigas* Nakai, commonly referred to as Korean Angelica or Giant Angelica, is a medicinal plant native to Korea. Traditionally, its root has been utilized in herbal medicine for various health benefits such as improvement of blood circulation, treatment of anemia, and serving as a sedative or tonic. Recent studies have examined its potential effects on memory enhancement, pain relief, anti-cancer activity, and its role in the management of vascular diseases. The bioactive compounds found in the root, particularly several pyranocoumarins including decursin, decursinol angelate, and decursinol, are believed to underpin these therapeutic properties. Despite the promising results from preclinical and some clinical investigations, there remains a notable lack of comprehensive systematic reviews and meta-analyses to definitively validate the efficacy and safety of *Angelica gigas* in humans.
Benefits
Research highlights several potential benefits of *Angelica gigas*, including anti-cancer effects, neuroprotection, and improved vascular health. Preclinical data suggest that extracts from this root can inhibit cell proliferation in cancer cells and induce apoptosis. Its ability to inhibit monoamine oxidases (MAO A and B) and β-secretase has implications for neurodegenerative disease management. Additionally, *Angelica gigas* has shown vasodilatory effects, suggesting contributions to cardiovascular health. Secondary benefits reported include sleep promotion, along with anti-inflammatory and anti-oxidative actions that may help in alleviating inflammation and oxidative stress. Populations suffering from menopausal symptoms and those at elevated stroke risk may find particular advantages; however, clinical significance and definitive effect sizes are yet to be fully established.
How it works
*Angelica gigas* exerts its effects through several biological pathways. It inhibits key enzymes such as MAO-A and MAO-B, potentially helping to reduce neurotoxic levels and protect against neurodegenerative diseases. Concomitantly, it mitigates the activation of RhoA, promoting enhanced vascular function. The extract's anti-inflammatory effects stem from its regulation of nitric oxide production, which enhances resilience to inflammation-related damage. Its bioactive compounds also interact with various cellular pathways, promoting cancer cell apoptosis and enhancing the survival of healthy cells.
Side effects
While generally considered safe based on traditional usage, *Angelica gigas* lacks comprehensive documentation of side effects due to a scarcity of clinical data. Preclinical studies have shown no significant toxicity in laboratory cell lines. However, common side effects remain largely unidentified, and no unusual or rare side effects have been reported. Limited exploration of drug interactions implies caution is warranted, especially for individuals with unspecified health issues or those taking concurrent medications. Pregnant, nursing women, and children should also exercise caution given the absence of safety data, underscoring a need for more detailed investigation in these populations.
Dosage
Current dosage guidelines for *Angelica gigas* are evolving, as optimal dosages for clinical applications are not well established. Various preclinical studies have administered doses ranging from 20 μg/mL to 200 μg/mL, though an effective minimum dose for humans is yet to be definitively identified. No specific timing suggestions for consumption have been documented, with ethanol extracts being the most commonly studied form. Future research is anticipated to elucidate absorption, bioavailability, and proper formulation to clarify recommended dosages for clinical use.
FAQs
Is *Angelica gigas* safe?
Though traditionally used safely, comprehensive safety data are limited, thus caution is advised.
When should I take *Angelica gigas*?
There are no specific timing recommendations available for taking this supplement.
What results can I expect?
Expected outcomes vary depending on the condition; more clinical trials are necessary to clarify results.
Are herbal supplements always safe?
There is a common misconception that herbal supplements are inherently safe, but they can cause drug interactions and side effects.
