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Aspergillus Oryzae

Also known as: Aspergillus glaucus, Aspergillus sojae, Aspergillus orizae, Koji mold, Aspergillus oryzae

Overview

*Aspergillus oryzae* is a filamentous fungus extensively employed in food fermentation, primarily within Asian cuisine, where it is crucial in producing soy sauce, sake, and miso. This organism synthesizes various stable and functional enzymes such as proteases, amylases, and lipases, which find application across food processing, pharmaceuticals, and dietary supplements. Notably, these enzymes perform effectively in diverse pH levels and temperature ranges, optimally functioning around pH 5.5 and between 35°C to 57°C. Its biochemical characteristics and established safety profile make *A. oryzae* a subject of considerable study, underscoring its important role in both food technology and health supplements.

Benefits

*Aspergillus oryzae* provides several scientifically supported health benefits: 1. **Hypocholesterolemic Effect**: Clinical evidence indicates that supplementation with *A. oryzae*-fermented products can significantly lower cholesterol, with trials demonstrating reductions from 215.5 mg/dL to 194.5 mg/dL in hyperlipidemic individuals (p = 0.001). 2. **Antioxidant Activity**: The enzymatic action enhances the antioxidant potential of food proteins, evidenced by high ORAC values in hydrolyzed soy proteins. 3. **Digestive Aid**: The enzymatic activities improve protein and carbohydrate digestion, benefiting those with impaired digestive functions and enhancing nutrient absorption, especially in individuals seeking nutritional augmentation.

How it works

The enzymes derived from *Aspergillus oryzae* work primarily by catalyzing biochemical reactions that enhance nutrient availability. Proteases break down dietary proteins into smaller peptides and amino acids, enhancing their absorption in the intestines. Simultaneously, amylases facilitate the conversion of carbohydrates into simpler sugars, optimizing carbohydrate metabolism. These enzymatic functions remain stable across various conditions, highlighting their effectiveness in supporting overall digestive health.

Side effects

The safety profile of *Aspergillus oryzae* enzymes is robust, with common side effects noted in less than 1% of cases. Clinical trials have reported no significant adverse effects, reinforcing the safety of these enzymes for general consumption. Some individuals with sensitivities may experience rare allergic reactions, particularly those with existing allergies to *Aspergillus* species. Importantly, no significant drug interactions have been documented. Pregnant and breastfeeding women are advised to consult healthcare professionals before usage to ensure safety.

Dosage

Recommended dosages of *Aspergillus oryzae* enzyme supplements can differ based on usage. A minimum effective dose of 20 U of protease per mL has shown to maximize antioxidant potential. Clinical trials suggest an intake of 34.5 g per day for cholesterol-related benefits. The highest acceptable levels, such as NOAELs of 1,000 mg TOS/kg bw per day for α-amylase, indicate a significant margin of safety. It is recommended to consume these supplements during meals to optimize digestive benefits, and they are available in various formats such as capsules and powders.

FAQs

Is *Aspergillus oryzae* safe?

Yes, *Aspergillus oryzae* enzymes are generally safe, but caution is advised for individuals with allergies to *Aspergillus*.

When should I take it?

It is best to take enzyme supplements with meals to enhance digestion and nutrient absorption.

What benefits can I expect?

You may experience improved digestion, potential reductions in cholesterol levels, and increased antioxidant activity.

Is this a substitute for medical treatment?

No, while beneficial, supplements are not replacements for professional medical advice or treatment.

Research Sources

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214319/ – This systematic review evaluates the effects of *Aspergillus oryzae* fermentation on food proteins, providing insights into its enzymatic profile and benefits such as cholesterol reduction and enhanced antioxidant properties. The review underscores the applications of these enzymes in both food technology and health care.
https://www.sciencedirect.com/science/article/pii/S0963996917303640 – This article explores the biochemical properties and health benefits of *Aspergillus oryzae*-derived enzymes, particularly their impact on digestion and metabolic health. The authors discuss mechanisms of action, clinical trial results, and practical applications in dietary supplements.