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Bifidobacterium Longum Infantis Bi02

Also known as: Bifidobacterium longum, Bifidobacterium infantis, Bifidobacterium longum 35624, Probiotics, Bifidobacterium longum Infantis Bi02

Overview

*Bifidobacterium longum Infantis Bi02* is a strain within the *Bifidobacterium* genus, known for its role as a probiotic. This species is naturally present in the human gut microbiome and is commonly found in fermented foods. Probiotics like *Bifidobacterium longum* are used for their potential health benefits, most notably in gut health support, alleviating symptoms of irritable bowel syndrome (IBS), and bolstering immune function. Research indicates that they can ferment complex carbohydrates and produce short-chain fatty acids, contributing to gut health maintenance. The body of research surrounding *Bifidobacterium* species is substantial, encompassing systematic reviews and various clinical studies that underscore its effectiveness, particularly in patients with IBS.

Benefits

Evidence suggests that *Bifidobacterium longum* 35624 may significantly alleviate IBS symptoms, including abdominal pain and bloating, improving the overall quality of life in patients. For instance, a randomized controlled trial by Sabaté et al. reported marked reductions in IBS severity after 30 days of treatment. Additionally, preliminary findings suggest *Bifidobacterium longum* may support immune system function and influence gut microbiota composition, though specific studies on *Bifidobacterium longum Infantis Bi02* are limited. Benefits are especially noted in adults suffering from IBS, with improvements often manifesting within a few weeks. The strongest evidence comes from RCTs demonstrating significant effect sizes for symptom management.

How it works

*Bifidobacterium longum* species work by modulating the gut microbiota composition, enhancing intestinal barrier function, and influencing immune responses primarily through cytokine regulation. They help maintain gut health by increasing the levels of beneficial short-chain fatty acids and reducing the IL-10/IL-12 cytokine ratio, which is linked to decreased inflammation. While probiotics overall are not absorbed like typical nutrients, they colonize the gut, where they exert their beneficial effects.

Side effects

*Bifidobacterium longum Infantis Bi02* is generally safe for most individuals, but some may experience mild gastrointestinal symptoms, such as bloating or gas, particularly during initial supplementation. Rarely, more severe gastrointestinal issues may arise, and very rarely, systemic infections could occur in immunocompromised individuals. Drug interactions are largely absent, but contraindications exist for significantly immunocompromised patients. Pregnant or breastfeeding individuals should approach with caution due to the limited safety data. Overall, adverse effects are minimal and often transient.

Dosage

The recommended dosage of *Bifidobacterium longum Infantis Bi02* typically ranges from 10^6 to 10^10 CFU per day, with optimal dosages for IBS observed around 10^9 CFU. While maximum safe doses are not formally established, higher doses (up to 10^10 CFU) have been administered without significant adverse effects. Probiotics are best taken with meals to enhance their survival through the digestive tract; common forms include capsules and powders. Due to the nature of probiotics, traditional absorption rates do not apply, as they are meant to colonize the gut rather than enter systemic circulation.

FAQs

How should I store probiotics?

Probiotics should be stored in a cool, dry place to maintain their viability, and some need refrigeration.

Are probiotics safe for everyone?

Generally, yes; however, individuals who are immunocompromised should consult a healthcare provider before use.

When is the best time to take probiotics?

Probiotics are most effective when taken with meals, which can help improve their survival in the gastrointestinal tract.

How long until I see results?

Improvements in IBS symptoms may be noticeable within a few weeks of consistent usage.

Are probiotics a cure for IBS?

No, probiotics are not a cure-all and efficacy can vary widely among individuals.

Research Sources

https://www.microbiotajournal.com/wp-content/uploads/sites/7/2024/06/e998.pdf – This study presents a randomized controlled trial that assesses *Bifidobacterium longum* 35624's effectiveness in managing IBS symptoms over an 8-week period, highlighting its role in normalizing inflammatory cytokine levels.
https://pubmed.ncbi.nlm.nih.gov/31753895/ – An RCT demonstrating significant reductions in abdominal pain and other IBS symptoms due to supplementation with *Bifidobacterium longum* 35624 at a dose of 10^8 CFU, emphasizing its potential therapeutic benefits.
https://pubmed.ncbi.nlm.nih.gov/37460707/ – This observational study shows that *Bifidobacterium longum* 35624 significantly improves IBS severity and overall quality of life metrics within 30 days, reinforcing its clinical effectiveness.
https://www.mdpi.com/2072-6643/16/20/3510 – Review article discussing probiotics' effect on gut health, with a focus on *Bifidobacterium longum*, establishing its relevance in dietary supplements for gastrointestinal issues.
https://www.researchgate.net/publication/376465273_Efficacy_and_Safety_of_Bifidobacterium_longum_Supplementation_in_Infants_A_Meta-Analysis_of_Randomized_Controlled_Trials – A meta-analysis assessing the efficacy and safety of *Bifidobacterium longum* supplementation in infants, though not specific to *Bifidobacterium longum Infantis Bi02*, discusses broader implications for its use in various populations.