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Cassia Bark Extract

Also known as: Cinnamomum cassia, Chinese cinnamon, Cassia cinnamon, Cinnamon bark extract, Cassia Bark Extract

Overview

Cassia bark extract is obtained from the bark of the Cinnamomum cassia tree, commonly referred to as Chinese cinnamon. It has a longstanding history of use in both culinary practices and traditional medicine, especially noted for its potential health benefits linked to glycemic control and lipid management. The principal active compound in the extract, cinnamaldehyde, imparts antioxidant and anti-inflammatory characteristics. The evidence supporting cassia bark extract is of moderate maturity, with systematic reviews and meta-analyses highlighting its effectiveness for individuals with type 2 diabetes mellitus (T2DM). Overall, the extract is seen as beneficial for metabolic health, particularly for improving blood sugar and lipid levels, with consistent use leading to observable health outcomes.

Benefits

Research indicates that cassia bark extract significantly aids individuals with type 2 diabetes. One meta-analysis involving 24 randomized controlled trials showed notable reductions in fasting blood sugar (SMD: -1.32), hemoglobin A1C (SMD: -0.67), and insulin resistance (SMD: -1.32), illustrating enhanced glycemic control. Another systematic review identified decreases in total cholesterol, LDL-C, and triglycerides, alongside increased HDL-C in those supplementing with cassia bark extract. These benefits are particularly relevant for T2DM management, demonstrating clinically significant results within a few weeks to months of consistent supplementation. While some antioxidant and anti-inflammatory benefits are cited, they are supported by less robust evidence compared to glycemic control findings.

How it works

The primary mechanism of action of cassia bark extract is attributed to its active compound, cinnamaldehyde, which enhances insulin sensitivity and facilitates glucose metabolism. The extract influences insulin signaling pathways, leading to a reduction in insulin resistance. Furthermore, it may enhance lipid metabolism by altering gene expression associated with cholesterol and triglyceride synthesis. Interaction with the body's endocrine and cardiovascular systems reinforces its role in improving metabolic health, contributing to better blood sugar and lipid profiles.

Side effects

Cassia bark extract is generally considered safe when consumed in moderate amounts. An umbrella review of meta-analyses has found no significant adverse effects at commonly utilized dosages. Side effects are infrequent, with no common occurrences (greater than 5%) reported, and only limited evidence of rare reactions. However, individuals taking blood thinners or diabetes medications should exercise caution due to the potential for interactions. Patients with liver disease should consult healthcare providers prior to use due to possible impacts on liver function. Pregnant or breastfeeding women are also advised to seek medical advice given the limited safety data on these populations.

Dosage

The minimum effective dosage of cassia bark extract for glycemic control is approximately 120 mg/day, with optimal ranges identified between 1-2 grams per day, typically over a period of 90 days. While some studies have explored higher dosages of up to 6 grams daily, routine recommendations favor lower dosages to minimize risk of side effects. It is advisable to consume cassia bark extract with meals to improve absorption, as taking it alongside fatty foods may enhance its bioavailability. There are no specific cofactors necessary for its efficacy.

FAQs

How long does it take to see benefits?

Benefits are typically observed within several weeks to a few months of consistent supplementation.

Can it be used with other medications?

Use with caution alongside blood thinners and diabetes medications due to potential interactions.

Is it safe for everyone?

Generally safe, but those with liver disease or pregnant/breastfeeding women should consult healthcare providers.

What is the expected result?

Improvement in glycemic control and lipid profiles in individuals with type 2 diabetes.

Is cassia bark extract a replacement for diabetes treatment?

No, it should be used as an adjunct therapy and not as a replacement for standard diabetes treatments.

Research Sources

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838969/ – A systematic review highlighting the beneficial effects of cassia bark extract on glycemic control in patients with type 2 diabetes, summarizing findings from various randomized controlled trials that measure fasting blood sugar, hemoglobin A1C, and insulin sensitivity.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982185/ – An umbrella review that summarizes multiple meta-analyses, indicating significant lipid profile improvements and safety assessments of cassia bark extract, emphasizing its role in lipid management and low incidence of side effects.