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Chamomile Glycerite Liquid Extract

Also known as: Chamomile, German chamomile, Matricaria recutita

Overview

Chamomile glycerite liquid extract is a preparation derived from chamomile flowers (*Matricaria recutita*) using a solvent mixture primarily of vegetable glycerin and water, specifically avoiding alcohol. This extraction method is designed to preserve the plant's bioactive compounds, such as flavonoids and terpenoids, which are responsible for its therapeutic effects. It is commonly utilized for its purported calming, anxiolytic, and sleep-promoting properties, as well as its mild anti-inflammatory and gastrointestinal soothing benefits. The glycerite form is particularly favored for individuals who need to avoid alcohol, offering a stable, sweet-tasting liquid alternative to traditional alcohol-based extracts or teas. While extensive research supports the general efficacy of chamomile, specific clinical data on the glycerite form are limited, with most evidence stemming from studies on chamomile in other forms like capsules or teas.

Benefits

Chamomile has demonstrated evidence-based benefits, particularly for anxiety and sleep quality. A 2019 systematic review and meta-analysis of 12 randomized controlled trials (RCTs) indicated that chamomile significantly improved symptoms of Generalized Anxiety Disorder (GAD), showing a modest anxiolytic effect with a mean reduction of approximately 1.4 to 1.8 points on the HAM-A scale after 2 to 4 weeks of treatment. The same meta-analysis also found a significant improvement in overall sleep quality. These benefits are most relevant for adults experiencing mild to moderate anxiety and sleep disturbances. While some studies have explored chamomile for other conditions, such as postoperative sore throat, RCTs have not shown significant benefits in these specific applications. The effects are typically modest and may take 2-4 weeks of consistent use to manifest. The strength of evidence for anxiety and sleep benefits is considered moderate to high, based on meta-analyses of multiple RCTs.

How it works

Chamomile's therapeutic effects are primarily attributed to its bioactive compounds, notably apigenin. Apigenin is believed to exert its mild sedative and anxiolytic effects by binding to benzodiazepine receptors within the central nervous system. Additionally, other flavonoids and terpenoids present in chamomile contribute to its anti-inflammatory and antioxidant properties, which may explain its traditional use for gastrointestinal discomfort and skin irritation. The glycerite extraction method is designed to preserve these delicate compounds without the potential degradation that can occur with alcohol, thereby maintaining their bioavailability and therapeutic efficacy in the final product.

Side effects

Chamomile is generally considered safe and well-tolerated when used appropriately. Mild adverse events, such as gastrointestinal discomfort or allergic reactions, have been reported in clinical trials but are rare, occurring in less than 5% of users. No serious adverse events or significant drug interactions have been consistently documented in clinical research. However, individuals with known allergies to ragweed or other plants in the Asteraceae family (e.g., chrysanthemums, marigolds, daisies) should exercise caution, as cross-reactivity can occur. Due to limited safety data, pregnant women and nursing mothers should consult a healthcare provider before using chamomile glycerite. While generally safe for long-term use, extensive long-term studies specifically on chamomile glycerite are limited.

Dosage

Dosage for chamomile glycerite liquid extract can vary depending on the concentration of the specific product. In clinical trials using other forms of chamomile extract, daily doses have ranged from 220 mg to 1100 mg. For glycerite liquid extracts, a common dosage range is typically 1 to 4 mL daily, often standardized to ensure consistent levels of active constituents. For optimal benefits related to anxiety and sleep, consistent daily administration for at least 2 to 4 weeks is generally recommended. The glycerite form is particularly suitable for individuals who wish to avoid alcohol. It is important to follow the specific dosing instructions provided by the manufacturer or a healthcare professional, as concentrations can differ between products.

FAQs

Is chamomile glycerite as effective as other forms?

While direct comparative studies are limited, chamomile glycerite is designed to preserve the active compounds found in chamomile, making it a viable and effective alcohol-free alternative to other forms like teas or alcohol extracts.

How soon can I expect to feel the effects?

For benefits related to anxiety and sleep, effects typically begin to manifest after 2 to 4 weeks of consistent daily use.

Is chamomile glycerite safe for long-term use?

Chamomile is generally considered safe for long-term use, but specific long-term studies on the glycerite form are limited. Consult a healthcare professional for prolonged use.

Can chamomile cause allergic reactions?

Yes, individuals with allergies to ragweed or related plants (e.g., chrysanthemums, marigolds) may experience allergic reactions due to cross-reactivity.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/31006899/ – This systematic review and meta-analysis of 12 RCTs investigated the efficacy of chamomile for anxiety and sleep. It found that chamomile significantly improved GAD symptoms and sleep quality, but had no significant effect on state anxiety or insomnia severity. The study highlighted heterogeneity in chamomile preparations and outcomes as a limitation.
https://pmc.ncbi.nlm.nih.gov/articles/PMC2995283/ – This double-blind, randomized controlled trial assessed the effectiveness of chamomile as an endotracheal tube lubricant to prevent postoperative sore throat and hoarseness. The study concluded that chamomile lubrication did not significantly reduce these postoperative complications, indicating a narrow scope of benefit for this specific application.