Get Your Personalized Supplement StackSupplement Stack Quiz

Coleus Forskohlii root extract

Also known as: Coleus forskohlii, Plectranthus barbatus, Coleus barbatus, Makandi, Patharchur

Overview

Coleus forskohlii is a plant native to India and Southeast Asia, traditionally used in Ayurvedic medicine. The root is the primary source of forskolin, a diterpenoid compound known for its potential biological activities. Forskolin is believed to activate adenylyl cyclase, an enzyme that increases intracellular levels of cyclic adenosine monophosphate (cAMP). Elevated cAMP levels can modulate various physiological processes, including hormone secretion, metabolism, and muscle contraction. Coleus forskohlii is available in various forms, including capsules and tablets, typically standardized to contain a specific percentage of forskolin. While traditionally used for heart conditions and asthma, it is now also investigated for potential benefits in weight management and improving body composition. However, the current body of research is preliminary, and more robust clinical trials are needed to confirm its efficacy and safety.

Benefits

Coleus forskohlii is purported to offer several health benefits, although the evidence supporting these claims varies. Some studies suggest it may help reduce blood pressure, potentially benefiting individuals with hypertension, though more research is needed. Preliminary evidence indicates that it may improve body composition by reducing fat mass and increasing lean body mass, particularly in men with obesity; one study reported a significant increase in free testosterone levels in this population. Additionally, some research suggests potential benefits in reducing asthma attacks and improving bone mineral density, although these findings are less consistent. The overall quality of evidence is limited by small sample sizes and inconsistent results, necessitating further investigation to validate these potential benefits.

How it works

Coleus forskohlii's primary mechanism of action is attributed to forskolin, which activates the enzyme adenylyl cyclase. This activation leads to an increase in intracellular levels of cyclic adenosine monophosphate (cAMP). cAMP acts as a second messenger, triggering a cascade of downstream effects that influence various biological processes. These processes include the regulation of hormone secretion, such as thyroid hormone and insulin, modulation of metabolic pathways involved in fat breakdown, and relaxation of smooth muscle, potentially affecting cardiovascular function. Forskolin's influence on cAMP levels can impact the cardiovascular, endocrine, and nervous systems, making it a subject of interest for various health conditions.

Side effects

Coleus forskohlii is generally considered safe at recommended doses, but it can cause side effects in some individuals. The most commonly reported side effect is diarrhea. Some users may also experience stomach discomfort. Due to its potential effects on blood pressure, individuals with hypotension should use it with caution. Coleus forskohlii may interact with antihypertensive medications, potentially leading to excessive lowering of blood pressure. It may also interact with anticoagulants, increasing the risk of bleeding. Additionally, it may affect stomach acid production, potentially interacting with stomach acid reducers. It is contraindicated in individuals with bleeding disorders or stomach ulcers. Pregnant women and individuals with pre-existing medical conditions should consult with a healthcare provider before using Coleus forskohlii.

Dosage

The recommended dosage of Coleus forskohlii extract typically ranges from 250 mg twice daily, providing a total of 500 mg per day. This dosage is usually standardized to contain 10% forskolin, resulting in a daily intake of 50 mg of forskolin. There are no specific timing recommendations for taking Coleus forskohlii. It is commonly available in capsule or tablet form. Due to its poor oral bioavailability, some formulations may aim to enhance absorption, but the effectiveness of these methods is not definitively established. The maximum safe dose of Coleus forskohlii is not well-established, so it is advisable to adhere to the recommended dosage and consult with a healthcare professional.

FAQs

What are the expected results from taking Coleus forskohlii?

Results can vary, but some users report improved body composition or reduced blood pressure. However, effects are not guaranteed and depend on individual factors.

Is Coleus forskohlii proven for weight loss?

While some studies suggest potential benefits for weight loss, particularly in men with obesity, it is not proven for weight loss in all populations. More research is needed.

Are there any safety precautions I should be aware of?

Yes, monitor your blood pressure and gastrointestinal health while taking Coleus forskohlii. Use with caution if you have hypotension, bleeding disorders, or stomach ulcers.

When is the best time to take Coleus forskohlii?

There are no specific timing recommendations for taking Coleus forskohlii. It can be taken at any time of day, but consistency is key.

Research Sources

https://intapi.sciendo.com/pdf/10.2478/pjct-2023-0025 – This study investigates the impact of Coleus Forskohlii on various health parameters. While the specific details require a deeper dive into the full text, the research aims to contribute to the understanding of its potential therapeutic applications.
https://examine.com/supplements/coleus-forskohlii/ – Examine.com provides a comprehensive overview of Coleus forskohlii, summarizing available studies and highlighting the need for more robust clinical trials. It serves as a valuable resource for understanding the current state of research on this supplement.
https://ods.od.nih.gov/factsheets/WeightLoss-HealthProfessional/ – This fact sheet from the National Institutes of Health (NIH) provides information on weight loss supplements, including Coleus forskohlii. It offers a general overview of the supplement's potential role in weight management and emphasizes the importance of evidence-based approaches.
https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1130003/full – This research article published in Frontiers in Endocrinology explores the effects of Coleus forskohlii on the endocrine system. The study likely investigates the supplement's impact on hormone levels and related physiological processes, contributing to a better understanding of its mechanisms of action.
https://www.researchgate.net/publication/301234875_An_evidence-based_review_Anti-obesity_effects_of_Coleus_forskohlii – This evidence-based review examines the anti-obesity effects of Coleus forskohlii. The review likely synthesizes findings from multiple studies to assess the supplement's effectiveness in promoting weight loss and improving body composition.