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Higenamine Hcl

Also known as: Higenamine, Norcoclaurine, Demethylcoclaurine, Higenamine hydrochloride

Overview

Higenamine hydrochloride, a compound found in plants like *Nandina domestica* and *Tinospora crispa*, is classified as a stimulant commonly marketed in pre-workout and weight-loss supplements. Although it has historical applications in traditional medicine for conditions like asthma and cough, robust scientific evidence supporting these uses is sparse. Higenamine exhibits mixed adrenergic receptor activity, particularly targeting beta-2 receptors, which may contribute to heightened cardiovascular activity. The research maturity level is low, with most studies based on animal models or in vitro experiments, and few human trails that meet scientific standards, highlighting the necessity for more definitive research to substantiate its effect and safety.

Benefits

The evidence for Higenamine's health benefits is minimal, particularly concerning athletic performance or weight loss in humans. Some animal studies indicate potential effects on heart health and asthma, yet these have not been validated in human populations. Notably, the lack of high-quality human data renders it impossible to determine effect sizes or clinical significance. Most claims regarding its efficacy are thus conjectural, necessitating further investigation to establish any reliable benefits or therapeutic applications.

How it works

Higenamine functions primarily by stimulating adrenergic receptors, particularly the beta-2 type, which can lead to an increase in heart rate and cardiac contraction strength. This mechanism suggests a possible role in enhancing cardiovascular performance and respiratory function, yet the exact molecular pathways and interaction specifics remain underexplored. Data on its absorption and bioavailability is notably lacking, making comprehensive understanding challenging.

Side effects

The safety profile for Higenamine remains uncertain and is deemed possibly unsafe due to potential cardiovascular side effects, including increased heart rate and blood pressure. More serious risks can include arrhythmias, which may occur in up to 5% of cases. Serious heart-related issues, while infrequent, cannot be entirely dismissed. Its risk is elevated in populations with pre-existing heart conditions or when taken alongside certain medications, specifically anticoagulants and those metabolized by CYP2D6 or CYP3A4. Pregnant or breastfeeding individuals should also avoid Higenamine, and caution is advisable prior to surgical procedures. Individuals should be aware of these risks, especially if they have underlying health issues.

Dosage

There is no established minimum effective dose for Higenamine, with typical supplement formulations containing doses ranging from trace amounts up to 62 mg per serving. However, there is no definitive guideline for optimal dosages, and maximum safe limits remain undefined due to safety concerns associated with stimulant effects. There are no specifications regarding ideal timing for administration, nor are there guidelines pertaining to absorption rates, further complicating effective dosing recommendations.

FAQs

Is Higenamine allowed in sports?

Yes, Higenamine is prohibited in competitive sports due to its stimulant properties.

Is Higenamine safe for everyone?

No, Higenamine may pose risks, especially for individuals with heart conditions, and is considered possibly unsafe.

What are the expected benefits of using Higenamine?

Current evidence does not support reliable benefits from Higenamine use, especially in humans.

Can Higenamine interact with other medications?

Yes, Higenamine may interact with anticoagulants and certain medications metabolized by CYP enzymes.

What is a common misconception about Higenamine?

It is often confused with aconite, which is a different and potentially toxic substance.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/32936964/ – This study examines the presence and labeling accuracy of Higenamine in dietary supplements. While it highlights the prevalence of Higenamine in various products, it fails to provide direct evidence regarding its efficacy or safety for human use.
https://www.usada.org/spirit-of-sport/higenamine-what-athletes-need-to-know-to-compete-clean/ – This source discusses Higenamine's status in sports and its classification as a prohibited stimulant. It emphasizes the need for athletes to be aware of potential health risks associated with its use.
https://www.webmd.com/vitamins/ai/ingredientmono-1265/higenamine – WebMD offers a general overview of Higenamine, noting its stimulant nature and usage in supplements, but emphasizes the lack of solid clinical evidence for its claimed benefits.
https://www.medchemexpress.com/higenamine-hydrochloride.html – This resource provides chemical details and potential applications of Higenamine, yet it notes the necessity for further research to determine its safety and efficacy in humans.
https://www.sigmaaldrich.com/BE/en/product/sial/phl83509 – This product page outlines the chemical properties of Higenamine, detailing its applications, but reiterates the absence of clinical studies confirming its benefits for human health.