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Lactobacillus Rhamnosus Pxn 54

Also known as: Lactobacillus rhamnosus, Probiotic bacteria, L. rhamnosus

Overview

Lactobacillus rhamnosus is a probiotic bacteria species naturally found in fermented foods and the human gut. It is widely recognized for its potential to support gastrointestinal health and modulate the immune system. This probiotic is known for its ability to adhere to intestinal epithelial cells, allowing it to colonize the gut effectively. While various strains exist, Lactobacillus rhamnosus GG is the most extensively researched. It is available in various forms, including capsules, powders, and fermented foods. Supplementation is commonly used to promote a balanced gut microbiota and support overall well-being. Research suggests potential benefits in managing conditions like cow's milk allergy and acute gastroenteritis, although results can vary depending on the specific strain and individual factors. More research is needed to fully understand the effects of specific strains like Pxn 54.

Benefits

Lactobacillus rhamnosus, particularly the GG strain, has demonstrated several potential health benefits. It supports gut health by promoting a balanced microbiota and enhancing gut barrier function. Strong evidence suggests it may aid in immune tolerance, especially in children with cow's milk allergy, with studies showing a significant risk ratio of 2.22 (95% CI, 1.86–2.66) for improved tolerance. Some studies indicate potential benefits in reducing symptoms of acute gastroenteritis, although the evidence is less consistent. Limited evidence suggests it may help with functional constipation in children, but more research is needed. It's important to note that benefits can vary depending on the specific strain and individual factors.

How it works

Lactobacillus rhamnosus exerts its effects primarily by modulating the gut microbiota and influencing immune function. It interacts with the gastrointestinal and immune systems, promoting a balanced gut environment. While specific molecular targets for the Pxn 54 strain are not well-defined, probiotics generally influence gut barrier function and cytokine production. By colonizing the gut, Lactobacillus rhamnosus can enhance the integrity of the intestinal lining, preventing the translocation of harmful substances. This modulation of the gut environment can lead to improved immune responses and overall gut health.

Side effects

Lactobacillus rhamnosus is generally considered safe for most individuals. Common side effects are typically mild and gastrointestinal in nature, such as bloating or gas. Uncommon side effects may include systemic infections, but these are rare and primarily occur in immunocompromised individuals. Extremely rare cases of bacteremia have been reported. There are no well-documented drug interactions. However, it is generally not recommended for severely immunocompromised individuals. Caution is advised when administering to critically ill patients. Individuals with compromised immune systems should consult with a healthcare provider before using Lactobacillus rhamnosus supplements.

Dosage

The typical effective dose of Lactobacillus rhamnosus ranges from 1 to 10 billion CFU per day. For general health support, a dosage of 1-2 billion CFU is often recommended. While a maximum safe dose is not well-defined, high doses are generally well-tolerated. It is often recommended to take Lactobacillus rhamnosus with food to enhance its survival through the stomach acid. It is available in various forms, including capsules and fermented foods. Survival through stomach acid is a crucial factor for its effectiveness. No specific cofactors are required for its absorption or function.

FAQs

How should I store Lactobacillus rhamnosus supplements?

Store probiotics in a cool, dry place to maintain viability. Avoid exposure to heat and moisture, which can reduce the number of live bacteria.

Is Lactobacillus rhamnosus safe for everyone?

Generally safe, but consult a healthcare provider if immunocompromised or critically ill. Mild gastrointestinal symptoms may occur initially.

When is the best time to take Lactobacillus rhamnosus?

Take with meals to enhance survival through stomach acid. Consistent daily intake is generally recommended for optimal results.

How long does it take to see results from Lactobacillus rhamnosus supplementation?

Benefits may be noticeable within weeks of consistent use. Individual results vary depending on factors like diet and overall health.

Is Lactobacillus rhamnosus a cure-all for digestive issues?

No, probiotics are not a cure-all. Individual results vary, and they are most effective when combined with a healthy diet and lifestyle.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/26365389/ – This study investigates the effect of Lactobacillus rhamnosus GG supplementation on preventing atopic dermatitis in infants. The research suggests that early supplementation with this probiotic strain may reduce the risk of developing atopic dermatitis in high-risk infants, highlighting its potential role in immune modulation and allergy prevention.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5563334/ – This systematic review examines the effectiveness of probiotics for treating functional constipation in children. The findings indicate that there is limited evidence to support the use of probiotics for this condition, suggesting that more robust studies are needed to determine their efficacy and specific strains that may be beneficial.
https://www.worldgastroenterology.org/UserFiles/file/guidelines/probiotics-and-prebiotics-english-2023.pdf – This guideline provides recommendations on the use of probiotics and prebiotics in various gastrointestinal conditions. It offers evidence-based guidance for healthcare professionals, summarizing the current understanding of the benefits and limitations of probiotic and prebiotic interventions in managing digestive health.
https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2021.727127/full – This study focuses on the role of Lactobacillus rhamnosus GG in promoting immune tolerance in children with cow's milk allergy. The research demonstrates that supplementation with this probiotic strain can significantly improve immune tolerance, reducing allergic reactions and improving overall health outcomes in affected children.
https://ijms.sums.ac.ir/article_48720.html – This meta-analysis evaluates the impact of probiotics on diarrhea induced by chemoradiotherapy. The results suggest that probiotics may not significantly reduce the incidence or severity of diarrhea in patients undergoing chemoradiotherapy, indicating that other interventions may be necessary to manage this side effect effectively.