Organic Coriolus Versicolor
Also known as: Coriolus versicolor, Trametes versicolor, Turkey tail, Yunzhi
Overview
*Coriolus versicolor*, also known as Turkey tail or Yunzhi, is an edible mushroom found worldwide, prized for its colorful appearance and use in traditional Chinese medicine. It is primarily used as a dietary supplement to enhance immune function and support cancer treatment. The mushroom contains polysaccharide peptide (PSP) and polysaccharide krestin (PSK), believed to contribute to its immunostimulating effects. Research maturity is moderate, with several clinical trials and meta-analyses examining its effects on cancer and immune function. Evidence generally supports its benefits in cancer treatment, particularly in improving survival and quality of life, but more rigorous studies are needed to fully understand its effects. It is available in various forms, including capsules, powders, and extracts.
Benefits
*Coriolus versicolor* demonstrates potential benefits, particularly for cancer patients. A meta-analysis indicated that *C. versicolor* and *Ganoderma lucidum* related products were associated with lower mortality (HR: 0.82; 95% CI: 0.72, 0.94) and higher total efficacy in cancer treatment (RR: 1.30; 95% CI: 1.09, 1.55). A systematic review also noted overall survival benefits in breast, gastric, and colorectal cancer when combined with chemotherapy. Secondary effects include enhanced immune function, potentially by increasing CD3 and CD4 levels. These benefits are most notable in cancer patients undergoing chemotherapy, with effect sizes suggesting a moderate benefit in cancer survival and immune function enhancement. The time course varies depending on the specific application and study design.
How it works
*Coriolus versicolor* primarily acts through immunomodulation, enhancing both innate and adaptive immune responses. Its polysaccharides can activate macrophages and stimulate T-cell production of cytokines like IFN-γ and IL-2. It interacts with the immune system by activating various signaling pathways, including MAPK and NF-κB. The polysaccharides in *C. versicolor* target immune cells and pathways, though specific molecular targets are less well-defined. The bioavailability of its active compounds is not extensively studied, but they are generally considered to be well-absorbed when taken orally.
Side effects
*Coriolus versicolor* is generally considered safe with minimal adverse effects reported in clinical studies. Common side effects (>5%) are not well-documented, but typically include mild gastrointestinal symptoms. Uncommon side effects (1-5%) are rarely reported, but may include allergic reactions. Rare side effects (<1%) are not well-documented. There is minimal evidence of significant interactions with conventional drugs, though caution is advised when used with chemotherapy due to potential effects on immune function. There are no well-established contraindications, but caution is advised in immunocompromised individuals. Pregnant or breastfeeding women should consult healthcare providers before use due to limited data.
Dosage
The minimum effective dose of *Coriolus versicolor* is not well-established, but typically ranges from 1 to 3 grams per day of the dried mushroom or extract. The optimal dose varies depending on the specific extract (e.g., PSP or PSK) and the condition being treated. There is no well-defined maximum safe dose, but high doses are generally not recommended without medical supervision. It is best taken with meals to minimize gastrointestinal upset. Capsules or powders are common forms; extracts like PSP and PSK may be more bioavailable. Absorption may be enhanced by taking with fatty meals. No specific cofactors are identified.
FAQs
How do I choose between PSP and PSK extracts?
PSP is often used for general immune support, while PSK is more commonly used in conjunction with conventional cancer treatments. Consult with a healthcare provider to determine the most appropriate extract for your specific needs.
Is it safe to use with chemotherapy?
Generally considered safe, but it's crucial to consult a healthcare provider, especially if you are undergoing chemotherapy or other cancer treatments, to ensure there are no potential interactions or contraindications.
How often should I take it for immune support?
For immune support, it is best taken consistently over time. Follow the recommended dosage guidelines and consult with a healthcare professional for personalized advice.
Will this cure my cancer?
While not a cure, *Coriolus versicolor* may support conventional treatments and improve immune function. It's important to manage expectations and consult with healthcare professionals for comprehensive cancer care.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/31333449/ – This meta-analysis of 4,246 cancer patients found that *C. versicolor* and *G. lucidum* products were associated with lower mortality and higher efficacy in cancer treatment. The study highlights the potential benefits of these fungal supplements in cancer therapy, though heterogeneity among studies was noted.
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.857864/full – This systematic review and meta-analysis indicated overall survival benefits in breast, gastric, and colorectal cancer when *Coriolus versicolor* was combined with chemotherapy. The review suggests that *C. versicolor* can be a valuable adjunct to conventional cancer treatments, improving patient outcomes.
- https://www.mdpi.com/1422-0067/24/5/4864 – These in vitro and in vivo studies demonstrate the immunomodulatory effects and potential anticancer activity of *Coriolus versicolor*. The studies show that *C. versicolor* can activate immune cells and pathways, suggesting a mechanism for its therapeutic effects, though translation to human clinical outcomes is limited.
- https://www.mdpi.com/2227-9059/8/5/135 – This study provides insights into the immunomodulatory properties of *Coriolus versicolor*, highlighting its ability to modulate immune responses. The findings contribute to understanding the mechanisms by which *Coriolus versicolor* may exert its therapeutic effects.
- https://www.eurekaselect.com/article/39867 – This article discusses the potential therapeutic applications of *Coriolus versicolor*, focusing on its role in cancer treatment and immune support. It provides a comprehensive overview of the current research and clinical evidence supporting the use of *Coriolus versicolor* as a complementary therapy.