Ostivone
Also known as: Ipriflavone, Ostivone
Overview
Ipriflavone is a synthetic derivative of the isoflavone genistein, primarily used for the treatment and prevention of osteoporosis, particularly in postmenopausal women, and for Paget's disease. As a phytoestrogen, it mimics the effects of estrogen in the body, which is crucial for maintaining bone health. It is not naturally occurring and is synthesized for therapeutic purposes. Ipriflavone is known for its potential to enhance bone mineral density (BMD) and reduce bone pain. The research on ipriflavone is moderately mature, with several clinical trials and systematic reviews available. It is typically administered orally and often combined with calcium supplementation to enhance its effects on bone health. While generally considered safe under medical supervision, long-term use requires monitoring for potential side effects such as lymphocytopenia.
Benefits
Ipriflavone, when taken with calcium, can prevent bone loss and potentially increase BMD in postmenopausal women. Systematic reviews and meta-analyses indicate that ipriflavone can improve BMD at the lumbar spine, femoral neck, and distal radius. Studies on isoflavones, which ipriflavone is derived from, show significant improvements in BMD. There is also evidence that ipriflavone can decrease bone pain in patients with Paget's disease. The primary population benefiting from ipriflavone is postmenopausal women, who are at a higher risk of osteoporosis. Benefits are generally observed over a period of at least 12 months, indicating a long-term treatment approach. Ipriflavone combined with estrogen or calcium may enhance its effects on bone health.
How it works
Ipriflavone acts by mimicking the effects of estrogen, which is crucial for maintaining bone health. It interacts with estrogen receptors (ERα and ERβ), promoting bone formation and inhibiting bone resorption. It primarily affects the skeletal system by enhancing osteoblastic activity and reducing osteoclastic activity. Ipriflavone is taken orally and its bioavailability is moderate. Its action on estrogen receptors helps to maintain bone density and reduce bone turnover, making it effective in treating conditions like osteoporosis and Paget's disease.
Side effects
Ipriflavone is generally considered safe when used under proper medical supervision. There is limited data on common side effects, but it is known to be well-tolerated in most individuals. Long-term use (greater than six months) can lead to lymphocytopenia (a decrease in white blood cell count). No significant rare side effects are documented in the literature. Ipriflavone can interact with medications metabolized by the liver, such as CYP1A2 and CYP2C9 substrates, and may increase the effects and side effects of these medications. It also interacts with immunosuppressants and theophylline. Due to insufficient information, it is not recommended for use during pregnancy and breastfeeding. Caution is advised when using ipriflavone in individuals with compromised immune systems or those taking immunosuppressive medications.
Dosage
For osteoporosis, the typical dose is 200 mg three times daily. For Paget's disease, the dose can range from 600-1200 mg daily. The optimal dosage is typically in the range of 600-1200 mg per day, divided into multiple doses. There is no established maximum safe dose, but long-term use should be monitored for potential side effects. Dosing should be consistent and spread throughout the day to maintain therapeutic levels. Oral administration is the standard form. Absorption may be enhanced when taken with meals, though specific data is limited. Calcium supplementation is often recommended to enhance the effects of ipriflavone on bone health.
FAQs
Is ipriflavone safe?
Ipriflavone is generally safe, but long-term use requires monitoring for lymphocytopenia. Consult with a healthcare provider before starting supplementation.
How should I take ipriflavone?
Consistent dosing throughout the day is recommended, typically divided into multiple doses. Follow your healthcare provider's instructions for optimal results.
What results can I expect from ipriflavone?
Improvements in BMD and reduction in bone pain can be expected over several months with consistent use and proper dosage, as indicated by clinical studies.
Is ipriflavone a natural isoflavone?
No, it is a synthetic derivative of a natural isoflavone. Its use in bodybuilding is not supported by scientific evidence; it's primarily for bone health.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/37875614/ – This systematic review and meta-analysis of 63 RCTs involving 4,754 participants found that isoflavone interventions, particularly those containing genistein ≥ 50 mg/day, significantly improved BMD in postmenopausal women. The interventions lasted ≥ 12 months, highlighting the long-term benefits of isoflavones on bone health.
- https://www.webmd.com/vitamins/ai/ingredientmono-310/ipriflavone – WebMD provides general information on ipriflavone, noting its use for osteoporosis and Paget's disease. It also mentions potential drug interactions and the importance of consulting a healthcare provider before use.
- https://pubmed.ncbi.nlm.nih.gov/29279934/ – This meta-analysis of RCTs involving 51,145 participants highlights the importance of calcium and vitamin D in bone health. While it does not specifically address ipriflavone, it underscores the relevance of these nutrients when using ipriflavone in combination for bone health.
