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Perilla Seed Extract

Also known as: Perilla, Shiso, Perilla Seed Extract, Perilla frutescens

Overview

Perilla seed extract is derived from the seeds of *Perilla frutescens*, a plant native to Asia. It is rich in bioactive compounds such as linolenic acid and various flavonoids. It is commonly used for its antioxidant, anti-inflammatory, and immunomodulatory effects, as well as potential benefits in cardiovascular health and immune function. The extract is high in omega-3 fatty acids, particularly alpha-linolenic acid (ALA), which contributes to its health benefits. Research on perilla seed extract is moderately mature, with increasing studies on its health effects, but more systematic reviews are needed. The quality of available evidence is variable, with some studies showing promising results, but more rigorous trials are needed for definitive conclusions. It is available in various forms, including oil and extracts.

Benefits

Perilla seed extract offers several potential health benefits. It exhibits antioxidant and anti-inflammatory properties, which may contribute to its overall health benefits. Animal studies suggest that perilla seed peptides can enhance immune function by improving spleen and thymus indexes. The omega-3 content may support cardiovascular health by aiding in lipid lowering. Some research indicates potential neuroprotective effects, although further studies are required. It may be particularly beneficial for individuals with compromised immune systems or those seeking antioxidant support. While specific effect sizes are not well-documented, studies suggest potential clinical significance in improving immune function and reducing inflammation. Benefits may be observed over several weeks of consistent use.

How it works

Perilla seed extract's mechanism of action involves several biological pathways. Its flavonoids and other bioactive compounds may inhibit inflammatory pathways, contributing to its anti-inflammatory effects. It enhances immune function by affecting lymphoid organs. The extract interacts with the immune system and potentially the cardiovascular system through its omega-3 content. While specific molecular targets are not well-defined, it likely involves modulation of inflammatory mediators and immune cell function. Omega-3 fatty acids are generally well-absorbed when consumed as part of a balanced diet, although specific absorption and bioavailability data for perilla seed extract are limited.

Side effects

Perilla seed extract is generally considered safe, but long-term effects are not well-studied. Common side effects are not well-documented. Uncommon side effects may include potential gastrointestinal upset due to the high omega-3 content. Rare side effects could include allergic reactions, although these are infrequent. It may interact with anticoagulants due to its omega-3 content, so caution is advised in individuals with bleeding disorders. Pregnant or breastfeeding women should consult healthcare providers before use. Monitor for any adverse reactions and discontinue use if they occur.

Dosage

Optimal dosage ranges for perilla seed extract are not definitively established, but typically, perilla seed oil is used in amounts providing 1-3 grams of ALA per day. The minimum effective dose and maximum safe dose are not well-defined. It is best taken with meals to enhance absorption. Common forms include oil or extract. Absorption may be enhanced with a balanced diet. There are no established required cofactors. Due to potential interactions with anticoagulants, individuals on blood-thinning medications should consult their healthcare provider before use.

FAQs

How should I ensure the quality of perilla seed extract?

Ensure the product is from a reputable source to avoid contamination and verify the purity and concentration of active compounds.

Are there any safety concerns I should be aware of?

Perilla seed extract is generally safe, but monitor for allergic reactions or gastrointestinal upset. Consult a healthcare provider if you have any underlying health conditions.

When is the best time to take perilla seed extract?

It is best taken with meals to enhance absorption of its omega-3 fatty acids and other bioactive compounds.

How long does it take to see the benefits of perilla seed extract?

It may take several weeks of consistent use to notice potential benefits, such as improved immune function or reduced inflammation.

Can perilla seed extract replace medical treatment?

No, it is not a substitute for medical treatment. Consult a healthcare provider before use, especially if you have existing health conditions or are taking medications.

Research Sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC10045045/ – This review of perilla seed oil highlights its antioxidant, anti-inflammatory, and lipid-lowering effects, providing a comprehensive overview of its potential health benefits. However, it lacks specific clinical trial data, indicating a need for more rigorous studies to confirm these effects in humans. The review suggests that perilla seed oil could be a valuable supplement due to its rich composition of bioactive compounds.
https://www.mdpi.com/2304-8158/13/22/3615 – This study focuses on the immunomodulatory effects of perilla seed peptides, showing that they enhance immune function by improving spleen and thymus indexes in animal models. While the results are promising, human trials are needed to validate these findings and determine the clinical significance of perilla seed peptides in improving immune response. The research suggests a potential role for perilla seed peptides in supporting immune health.
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.763624/full – This study found that perilla leaf extract reduces airway inflammation in COPD models, indicating potential anti-inflammatory effects. Although the study focuses on leaf extract rather than seed extract, it supports the broader anti-inflammatory properties of *Perilla frutescens* extracts. The findings suggest that perilla extracts could be beneficial in managing inflammatory respiratory conditions.
https://www.mdpi.com/2304-8158/14/1/47 – This paper investigates the potential health benefits of perilla seed oil, emphasizing its high content of omega-3 fatty acids and other bioactive compounds. It reviews the existing literature, highlighting the antioxidant, anti-inflammatory, and cardiovascular benefits associated with perilla seed oil consumption. The study calls for more clinical trials to confirm these effects and establish optimal dosage recommendations.
https://biomedpharmajournal.org/vol12no2/a-review-on-nutritional-value-functional-properties-and-pharmacological-application-of-perilla-perilla-frutescens-l/ – This review provides a comprehensive overview of the nutritional value, functional properties, and pharmacological applications of *Perilla frutescens*. It discusses the various bioactive compounds present in perilla and their potential health benefits, including antioxidant, anti-inflammatory, and immunomodulatory effects. The review highlights the need for further research to fully understand and harness the therapeutic potential of perilla.