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Polygonum Multiflorum Root Extract

Also known as: Polygonum multiflorum Thunb., He-Shou-Wu, Fo-ti, Polygonum multiflorum

Overview

Polygonum multiflorum, also known as He-Shou-Wu or Fo-ti, is a plant traditionally used in Chinese medicine. It is primarily consumed as a root extract and is purported to offer benefits such as promoting hair growth, improving liver health, and enhancing overall well-being. While it has been used for centuries, modern scientific research on Polygonum multiflorum is still evolving. The extract is believed to improve hair color, enhance liver function, and treat conditions like insomnia and constipation. However, the quality of evidence supporting these claims varies, and caution is advised due to potential liver-related side effects. It is available in various forms, with processed forms considered safer than raw extracts.

Benefits

Some animal studies suggest that Polygonum multiflorum may reduce hepatic lipid accumulation and improve insulin sensitivity. However, human studies are limited, and the evidence for direct health benefits in humans is not robust. Traditional uses include improving hair color and treating various health conditions, but these are not well-supported by modern clinical trials. There is some evidence that it may help with non-alcoholic fatty liver disease in animal models, but human data is lacking. Quantitative data on effect sizes is limited due to the scarcity of well-designed human trials. The onset of potential benefits is not well-documented in human studies.

How it works

Polygonum multiflorum extract may influence lipid metabolism and insulin sensitivity through various bioactive compounds like stilbenes and anthraquinones. It is believed to interact with liver function by modulating enzymes related to lipid metabolism and reducing inflammation. While specific molecular targets are not well-defined, they may include pathways related to lipid metabolism and inflammation. The bioavailability of its active compounds is not well-studied, but processing methods may affect absorption. Further research is needed to fully elucidate its mechanisms of action.

Side effects

While traditionally used, Polygonum multiflorum can cause liver injury, particularly if not properly processed. Common side effects include liver injury symptoms such as jaundice and fatigue. Severe liver damage is a rare but significant concern. Potential interactions with other medications are not well-studied. Individuals with liver conditions should exercise caution, and pregnant or breastfeeding women should consult healthcare providers before use. It is crucial to ensure the extract is properly processed to minimize liver injury risk. Symptoms typically appear within a month of use.

Dosage

The minimum effective dose of Polygonum multiflorum is not well-established in human studies. Typical dosages vary from 3 g/d to 20 g/d, but optimal dosing is unclear. The maximum safe dose is not defined due to potential liver toxicity risks. There are no specific timing recommendations available. Processed forms are considered safer than raw extracts. Bioavailability may vary based on processing and individual factors. Due to the risk of liver injury, it is essential to consult with a healthcare provider before starting Polygonum multiflorum supplementation.

FAQs

Is Polygonum multiflorum safe to use?

It can cause liver injury, especially if not properly processed. Consult a healthcare provider before use, particularly if you have liver issues.

How should I take Polygonum multiflorum?

There is no specific guidance on timing or administration. Follow the recommendations of a healthcare provider or the product label.

What are the expected benefits of Polygonum multiflorum?

Benefits are largely anecdotal and not well-supported by clinical evidence. It is often believed to have broad health benefits without strong scientific backing.

What are the risks associated with Polygonum Multiflorum?

The most significant risk is liver injury, which can be severe. Ensure the extract is properly processed and consult with a healthcare provider before use.

Research Sources

https://www.wjgnet.com/2307-8960/full/v9/i20/5490.htm – This systematic review analyzed 91 cases of liver injury associated with Polygonum multiflorum. The study found that liver injury was more common in middle-aged men without significant risk factors, and symptoms typically appeared within a month of use. The study is limited by its reliance on case reports rather than controlled trials.
https://pubmed.ncbi.nlm.nih.gov/32693115/ – This review suggests that processed Polygonum multiflorum may have therapeutic effects on liver diseases but can also cause liver injury if improperly used. The review highlights the dual nature of the herb, noting potential benefits alongside risks. However, the review did not include human clinical trials, limiting its applicability to human health.
https://www.mdpi.com/2072-6643/12/8/2353 – An animal study using mice fed a high-fat diet found that Polygonum multiflorum extract reduced hepatic lipid accumulation and improved insulin sensitivity. While these findings are promising, they are based on an animal model and may not directly translate to humans. Human trials are needed to confirm these potential benefits.
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2018.00364/full – This study investigates the protective effects of Polygonum Multiflorum against liver damage. The research suggests that certain compounds in the herb may help mitigate liver injury, but further research is needed to fully understand the mechanisms and ensure safe usage.