Red Peony Root Extract
Also known as: Paeonia veitchii, Red Peony Root, White Peony Root, Paeonia lactiflora
Overview
Red Peony Root Extract is derived from the roots of *Paeonia lactiflora* or *Paeonia veitchii*, recognized for its medicinal properties within traditional Chinese medicine (TCM). Known for its anti-inflammatory effects, it has been traditionally used to treat conditions such as rheumatoid arthritis and various inflammatory diseases. The extract contains several bioactive compounds, including total glucosides of peony (TGP), paeoniflorin, and albiflorin, which contribute to its efficacy. The research maturity surrounding red peony root extract is moderate, with clinical trials demonstrating promise but a limited number of systematic reviews assessing its overall effectiveness and safety.
Benefits
Red Peony Root Extract exhibits several evidence-based benefits. Primarily, it has shown anti-inflammatory, immunomodulatory, and analgesic effects, particularly helpful in treating autoimmune conditions such as lupus nephritis by inhibiting key cytokines including IL-8 and TNF-α. Additionally, its potential neuroprotective effects have been observed in models of acute cerebral ischemia, suggesting efficacy in reducing symptoms of neurological injuries through mechanisms like ferroptosis inhibition and activation of autophagy. However, despite these promising findings, the specific effect sizes and broader clinical significance require further investigation, especially in well-designed clinical trials.
How it works
The mechanism of action of Red Peony Root Extract involves modulation of immune responses and reduction of inflammation. Its bioactive compounds interact with key cytokines such as IL-8, TNF-α, and IFN-α, potentially affecting immune system dynamics. The extract may also exert neuroprotective effects, suggesting influence on the nervous and potentially the cardiovascular systems, thereby contributing to its therapeutic effects.
Side effects
Red Peony Root Extract is generally considered safe when used at appropriate doses; however, there is limited long-term safety data. Common side effects may include gastrointestinal upset, although they are not well-documented. There is a risk of allergic reactions and possible interactions with medications, particularly immunosuppressive drugs or anticoagulants. Special caution is advised for pregnant or breastfeeding individuals due to a lack of safety profiles, as well as for those with bleeding disorders or under anticoagulant therapy. The safety profile underscores the need for monitoring during use to mitigate potential adverse effects.
Dosage
The dosing guidelines for Red Peony Root Extract are not firmly established, but traditional medicine suggests a range of 3 to 9 grams of dried root per day, with modern recommendations typically between 1-3 grams of extract daily, based on the concentration of active compounds. While no upper safety limits have been firmly established, high doses may increase the risk of side effects. Consistent daily use with meals can enhance absorption, particularly in extract forms like capsules or decoctions, although specific absorption factors are not extensively studied.
FAQs
What should I look for when purchasing Red Peony Root Extract?
Ensure the product is from a reputable source to minimize contamination risks.
Is Red Peony Root Extract safe?
While generally considered safe, it's important to monitor for any allergic reactions or interactions with other medications.
When is the best time to take Red Peony Root?
It is recommended to take the extract consistently with meals to enhance absorption.
How long until I see results from Red Peony Root Extract?
Users may take several weeks of consistent use to notice benefits.
Can I use Red Peony Root Extract as a substitute for medical treatment?
No, it's not a substitute for medical treatment—consult a healthcare provider before use.
Research Sources
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.981063/full – This study reviews the potential of Red Peony Root Extract in inhibiting cytokines that may benefit lupus nephritis patients, indicating a direction for future clinical trials.
- https://pubmed.ncbi.nlm.nih.gov/25151277/ – Research clarifying genetic and chemical differentials between white and red peony roots, emphasizing the varying bioactive compounds which may influence efficacy.
- https://www.mdpi.com/1467-3045/46/9/601 – This study outlines the neuroprotective effects of red peony extracts, demonstrating benefits in cerebral ischemia models, while noting the lack of human trial data.
Supplements Containing Red Peony Root Extract
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