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Relora Patented Proprietary Blend

Also known as: Magnolia officinalis, Phellodendron amurense, Magnolia bark, Phellodendron bark, Relora®, Relora

Overview

Relora® is a proprietary blend derived from the bark of Magnolia officinalis and Phellodendron amurense, traditionally used in Chinese medicine. This supplement is distinguished by its standardized content, including at least 1.5% honokiol from Magnolia and 0.1% berberine from Phellodendron. While the research surrounding Relora is still developing, preliminary studies indicate promising applications for stress reduction, mood enhancement, and improved sleep quality, particularly among individuals experiencing moderate psychological stress. The blend emphasizes quality evidence derived from randomized controlled trials, suggesting its potential in promoting mental well-being. However, further comprehensive studies are required to establish consistent health benefits and long-term safety.

Benefits

Evidence-based benefits of Relora include significant stress reduction and mood improvement, as shown in a randomized controlled trial where participants exhibited an 18% reduction in salivary cortisol and marked decreases in various mood indices, with overall stress dropping by 11%. Additionally, athletes taking Relora experienced faster sleep onset by 28 minutes compared to a placebo group. Anxiolytic effects have also been documented in moderately stressed individuals, highlighting its utility particularly in populations under stress or those seeking sleep enhancement. The results indicate clinically significant benefits, marked by p-values below 0.05, suggesting efficacy in these applications.

How it works

Relora acts primarily through modulation of the hypothalamic-pituitary-adrenal (HPA) axis, which plays a crucial role in the body's stress response. By decreasing cortisol levels and potentially increasing dehydroepiandrosterone (DHEA), it helps restore balance in stress-related hormones. The active compounds, honokiol and berberine, interact with the nervous system mechanisms to promote mood regulation and anxiety relief, although specific molecular targets remain to be fully clarified.

Side effects

Relora has shown a favorable safety profile in clinical studies, with no significant adverse effects reported, even after four weeks of supplementation. Common side effects are not documented (>5%), and no uncommon or rare side effects have been identified. Although no significant drug interactions have been established, individuals using other medications should consider exercising caution due to limited interaction data. Additionally, there are no specific contraindications mentioned, but it is advisable for pregnant or breastfeeding women and those with severe medical conditions to consult with a healthcare provider prior to use. Overall, Relora is considered safe for use in the general population, provided the standard recommended precautions are followed.

Dosage

The suggested dosage range for Relora is between 200-400 mg per day, based on current studies that demonstrated efficacy within this range. While the minimum effective dosage is not precisely defined, these amounts have been used safely in trials. Relora may be taken at any time of the day, though some users prefer taking it before sleep to maximize its sleep-enhancing benefits. Available formulations typically include capsules or tablets, and no specific absorption factors are studied, but the standardized nature of Relora ensures consistent bioavailability of its key compounds. There is currently no established maximum safe dose, but usage up to 400 mg has not resulted in adverse events.

FAQs

When is the best time to take Relora?

Relora can be taken daily or as needed, with many users opting for a dose before sleep to enhance sleep quality.

Are there any known drug interactions?

There is no significant evidence of drug interactions, but caution is advised when used alongside other medications.

What side effects should I expect?

No significant side effects have been reported, making Relora generally safe for most individuals.

How long until I see results?

Benefits may be observed after about four weeks of consistent supplementation.

Is Relora a sedative?

No, Relora is not a sedative and does not produce tranquilizing side effects associated with some pharmaceuticals.

Research Sources

https://www.springermedizin.de/effect-of-magnolia-officinalis-and-phellodendron-amurense-relora/9593872 – This randomized controlled trial assessed the effects of Relora on stress and mood over four weeks. It reported a significant reduction in salivary cortisol and improvements in mood parameters, indicating strong support for Relora's efficacy in alleviating stress.
https://pubmed.ncbi.nlm.nih.gov/30844537/ – This study found that athletes taking a multivitamin with Relora experienced improved sleep latency, suggesting its potential benefits for sleep without negative impacts on sleep quality. The findings reinforce Relora's use among active populations.
https://openreview.net/forum?id=iifVZTrqDb – This review discusses proprietary blends like Relora in dietary supplements, focusing on regulatory challenges and implications for ingredient transparency, emphasizing caution in dosage disclosure.